Loading...

HLA alleles and haplotype frequencies in Iranian population

Ghafouri-Fard, S ; Sharif University of Technology | 2022

80 Viewed
  1. Type of Document: Article
  2. DOI: 10.3233/HAB-220004
  3. Publisher: IOS Press BV , 2022
  4. Abstract:
  5. BACKGROUND: HLA genotyping is a prerequisite for selection of suitable donors in the process of bone marrow transplantation. METHODS: In the current study, the frequencies of HLA-A, -B, -C and -DRB1 alleles and A-B-C-DRB1 haplotypes were assessed in 855 healthy Iranian persons using a low-resolution sequence specific primer (SSP) kit. RESULTS: Frequencies were compared between 11 subpopulations including Armani, Balouch, Bandari, Turk, Turkaman, Arab, Fars, Kurd, Gilaki, Lor and Mazani. In total, 17 HLA-A alleles were detected, one of which (HLA-A*74) was present only among Lors. HLA-A*23 and -A*26 were the most frequent HLA-A alleles among Armanis. HLA-A*23 was also common among Turkamans. HLA-A*11 and -A*26 were most frequent among the Balouch subpopulation. The former allele was also frequent among Bandaris. HLA-A*02 was identified as the most common HLA-A allele among Turk, Arab and Fars subpopulations. HLA-A*30 were strongly enriched among Gilakis. A total of 31 HLA-B alleles were detected across the target population. While all alleles were present among Fars subgroup, Armanis and Turkamans had the lowest degree of diversity among the alleles examined. Moreover, HLA-B*35 and B*49 alleles were strongly enriched among Armanis and Turkamans, respectively. A total of 13 HLA-C alleles were identified across the population, all of which were present in the Fars subpopulation. HLA-C*03 and C*04 were the only HLA-C alleles identified among the Bandari subpopulation. HLA-DRB1*08 was not detected in any subpopulation other than Fars. HLA-DRB1*16 was significantly enriched among Bandaris. These data have practical significance in anthropological studies, disease association investigations and bone marrow transplantation. © 2022 - IOS Press. All rights reserved
  6. Keywords:
  7. HLA ; Normal population ; Genomic DNA ; HLA A antigen ; HLA antibody ; HLA DRB1 antigen ; HLA B antigen ; HLA C antigen ; Bone marrow transplantation ; Disease association ; DNA extraction ; Gene frequency ; Gene locus ; Genetic variability ; Genotype ; Haplotype ; Human ; Iranian people ; Major clinical study ; Molecular genetics ; Phylogenetic tree ; Phylogeny ; Polymerase chain reaction ; Allele ; Genetics ; Alleles ; Haplotypes ; HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens ; HLA-DRB1 Chains ; Humans ; Iran
  8. Source: Human Antibodies ; Volume 30, Issue 2 , 2022 , Pages 79-96 ; 10932607 (ISSN)
  9. URL: https://pubmed.ncbi.nlm.nih.gov/35342084