Loading...

The effect of pore morphology and agarose coating on mechanical properties of tricalcium phosphate scaffolds

Gorgin Karaji, Z ; Sharif University of Technology | 2022

104 Viewed
  1. Type of Document: Article
  2. DOI: 10.1111/ijac.14093
  3. Publisher: John Wiley and Sons Inc , 2022
  4. Abstract:
  5. Three-dimensional biocompatible porous structures can be fabricated using different methods. However, the biological and mechanical behaviors of scaffolds are the center of focus in bone tissue engineering. In this study, tricalcium phosphate scaffolds with similar porosity contents but different pore morphologies were fabricated using two different techniques, namely, the replica method and the pore-forming agent method. The samples fabricated using the pore-forming agent showed more than two times higher compressive and bending strengths and more than three times higher compressive moduli. Furthermore, a thin layer of agarose coating improved the compressive and bending strength of both types of ceramic scaffolds. Subsequently, the samples’ capability to guide biomineralization was evaluated by immersion into a simulated body fluid that developed Ca-P nano-platelets formation and enhanced the compressive strength. Finally, the tetrazolium-based colorimetric (MTT) assay was used to evaluate L929 cell viability and proliferation on all the samples and confirmed that cell behavior was not affected by pore morphology or agarose coating. In summary, samples produced by the use of the pore-forming agent showed higher potential to be applied as bone scaffolds in tissue engineering applications. © 2022 The American Ceramic Society
  6. Keywords:
  7. Bone scaffold ; Mechanical properties ; Pore morphology ; Tricalcium phosphate (TCP) ; Bending strength ; Biocompatibility ; Biomechanics ; Body fluids ; Bone ; Calcium compounds ; Coatings ; Compressive strength ; Morphology ; Porosity ; Proteins ; Scaffolds (biology) ; Transmission control protocol ; Agarose ; Biological behavior ; Bone scaffolds ; Bone tissue engineering ; Mechanical behavior ; Pore-forming agents ; Pores morphology ; Porous structures ; Tri-calcium phosphates ; Tricalcium phosphate ; Biomineralization
  8. Source: International Journal of Applied Ceramic Technology ; Volume 19, Issue 5 , 2022 , Pages 2713-2722 ; 1546542X (ISSN)
  9. URL: https://ceramics.onlinelibrary.wiley.com/doi/abs/10.1111/ijac.14093