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Investigation of 3D Printed Microfluidic System for Continues Drug Synthesis

Niksefat, Matin | 2023

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 56319 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Kazemeini, Mohammad; Hosseinpour, Vahid
  7. Abstract:
  8. In recent years, batch systems were often used in the synthesis of pharmaceuticals. Nowadays, due to the possibility of more optimal conditions in flow systems, such as better mixing and optimal performance of heat transfer and mass transfer, process safety, reduction of retention time, and ease in increasing the scale of the process, the use of flow systems has been expanded. B-hydroxysulfone is a pharmaceutical intermediate in the production of bicalutamide, which is used in the treatment of prostate cancer and is used in many organic and biological processes. The reaction time in batch systems is about 17 to 20 hours, and in the flow system, the retention time has reached about 180-90 minutes. This flow system consists of three micro-reactors with the same volume and different surface-to-volume ratios, which were created using the design in SolidWorks software and the fused deposition model method. Due to the presence of many influential parameters such as temperature, retention time, catalyst and solvent, experiments were conducted using Design Expert software for this synthesis and CNMR and HNMR analysis were used to determine the characteristics. By changing the temperature and retention time, the amount of catalyst and the solvent, and with the help of Design Expert, the sensitivity of the yield to each of the inputs has been obtained, and the best yield with 67% has been achieved in the synthesis of this intermediate by the micro reactor system
  9. Keywords:
  10. Microreactor ; Drug Synthesis ; Continuous-Flow Synthesis ; Microfluidic System ; Three Dimentional Printing ; B Hydroxsolfune

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