Synthesis of Magnetic Fe3o4 Nanoparticle and Coating It with Modified Starch for Targeted Delivery of Doxorubicin Anticancer Drug

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Alizadeh, Mahshid | 2013

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 44563 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Pourjavadi, Ali
Abstract:
One of the major problems in cancer treatment is side effects of treatments. Today, scientists have developed smart nanocarrier for diagnosis and drug delivery that can circulate in the bloodstream, pass the body's immune system to kill cancer cells and attach to the cancer cells to deliver drugs, without the side effects that are in other treatments, such as chemotherapy. magnetic nanoparticles coated by biodegradable polymers are one of the smart polymers. In this study, iron oxide nanoparticles with amine group on their surface are coated by starch modified by methyl acrylate then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This bond is pH –sensitive .It was broken in acidic media (5 = pH) and targeted drug delivery achieved. The analysis test likeFT-IR, DLS, TEM demonstrate the synthesis of nanocarrier and their nanosize. The in vitro release of drug was examined by UV-Vis spectrometers
Keywords:
Magnetic Iron Oxide Nonoparticle ; Nanocarrier ; Cancer Tissue ; PH-Sensitive Polymer ; Cancer Treatment

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