Design and Fabrication of Conductive Nanofibrous Scaffolds in Nerve Tissue Engineering

Please enable javascript in your browser.

Soleymani, Maryam | 2015

732 Viewed

Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 48233 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Mashayekhan, Shohreh; Ramezani Saadat, Ahmad
Abstract:
The nervous system is the most important communication machine in body which regulates the function of other organs. Peripheral nerves in contrary to central nervous system have the potential for regeneration, but regrowth requires proper environmental conditions and supporting growth factors. Tissue engineered scaffolds create a suitable milieu for disconnected axon to regenerate. The aim of this study in the first stage is the fabrication of nanostructured of conductive polymers (graphene and polyaniline) within a bed of gelatin polymer and then conducting some analyses including conductance, degradation rate and tensile test besides morphological analyses of fibers through SEM and FTIR, in order to introduce the optimal scaffold for nerve tissue engineering application. The results in the present study show that the optimal scaffold is the sample containing 2% conductive polymer and 25% gelatin having Young's modulus of 24MPa and maximum stress of 35.9MPa which is an adequate mechanical strength for use in nerve tissue engineering. Furthermore it exhibits the proper conductance of 6.7×10-5 (S / cm)
Keywords:
Conductive Polymer ; Nerve Tissue Engineering ; Neurous System ; Mechanical Strength ; Nanofibrous Scaffold

No TOC