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Numerical simulation of a microfluidic system for regular glucose measurement

Najmi, A ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1109/ICBME49163.2019.9030418
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2019
  4. Abstract:
  5. The aim of this research is to design an implantable integrated microfluidic system in order to regularly measure the glucose level in the human body, nonenzymatically, using the microdialysis method. The main compartments of this system are a micropump, array of hollow microneedles and an electrochemical sensor. At the base of the microneedles, there are located semipermeable membranes, that when the pumped dialysis fluid passes over them, the glucose of the interstitial fluid diffuses into the dialysis fluid and then, in the sensor section, it is measured nonenzymatically using the amperometry method. Both the arrangement of the miconeedles and the amount of the dialysis fluid flow are selected so that the greatest possible recovery factor can be achieved while system's size, response time and the consumed dialysis liquid kept at the best minimum possible. In this article there have been accomplished the simulation of glucose mass transfer into the dialysis fluid and the simulation of the nonenzymatic sensor. The simulation of the nonenzymatic sensor, despite other researches on nonenzymatic sensors, which are merely experimental, helps to achieve a better understanding and optimization of the parameters effective on the glucose electrooxidation mechanism. © 2019 IEEE
  6. Keywords:
  7. Amperometry ; Dialysis fluid ; Hollow microneedles ; Interstitial fluid(ISF) ; Nonenzymatic sensor ; Biomedical engineering ; Dialysis ; Dialysis membranes ; Electrooxidation ; Flow of fluids ; Fluidic devices ; Glucose ; Mass transfer ; Microfluidics ; Needles ; Amperometry methods ; Glucose electrooxidation ; Glucose measurements ; Integrated microfluidic systems ; Interstitial fluids ; Micro fluidic system ; Non-enzymatic sensors ; Semi-permeable membranes ; Electrochemical sensors
  8. Source: 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 60-65 ; 9781728156637 (ISBN)
  9. URL: https://ieeexplore.ieee.org/document/9030418