Sharif Digital Repository

Conventional chemotherapy methods impact both normal and cancerous cells; therefore, it is essential to design novel drug delivery systems in order to reduce drugs’ side effects. Having high retention time in blood and the capability of crossing blood-brain barriers are the characteristics of nano-scaled drug delivery systems.The research thesis is about the synthesis and characterization of the light-sensitive biocompatible nanogels with the core-shell structure with the intention of Doxorubicin anti-cancer drug delivery. These smart nanogels possess a hydrophobic core coated with hydrophilic starch polymeric chain modified with beta-cyclodextrin. The formation of the core-shell structure... 

Successful formulation development for poor water soluble drugs is a critical, long-standing and challengeable problem in cancer treatment. One of the methods for transporting low-soluble drugs is using nanoparticles which are able to pass through capillary walls of tumor tissues due to their small size. An example of the nanoparticles is micelle systems. Functionalized β-cyclodextrin (β-CD) by hyper branched polyglycerol (HPG) can dissolve low-soluble compounds. This polymer can be used in preparing micelles. In this project, β-cyclodextrin (β-CD) by anionic reactions is initiator for polymerization of glycidol monomer. Hydrophobic cavity of the β-cyclodextrin (β-CD) in placing the phenyl... 

Antioxidants are compounds with anti-cancer, anti-bacterial, anti-viral, anti-aging and anti-allergic properties. In the present study, a quantum mechanical approach has been used to shed light on the presence effect of glycoside group on the antioxidant ability of chrysin as one of the most important consumable flavonoids and two glycoside derivatives, chrysin-6-C-fucopyranoside and chrysin-3-malonyl-6-C-fucopyranoside which has electron-withdrawing group (EWG) in its C3 of glycoside group. Density functional theory (DFT) using B3LYP and UB3LYP functional and split-valance 6-311++G ** basis set were used to optimize chrysin, its different derivatives, and their radicals. Analysis of... 

Paclitaxel is used as a drug against breast and ovarian cancers. Although paclitaxel has high biologic activity, it has very pour solubility in water like some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites. eta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project by adding polymeric polyacrylamide branches on beta-Cyclodextrin, polymeric nano structure has been developed to enhance water solubility in comparison with pure beta-Cyclodextrin. Study on producing polymeric nano... 

Today, human is facing and struggling with one of the most deadly disease, Cancer. Accordingly, several research studies are aimed to develop new anticancer drugs. Among the prescribed drugs are Paclitaxel. Unfortunately, despite the anticancer activity, paclitaxel has very low water solubility. To solve this problem several alternatives have been proposed by researchers, e.g. using co-solvents of ethanol:Cremophor El®, as is the case in commercial drug, Taxol®. Unfortunately, these co-solvents have some dangerous and sometimes mortal side effects. To reduce its side effects, researchers have proposed using cyclodextrin as a carrier for paclitaxel on the basis that cyclodextrin has a... 

Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin.
Study on producing... 

One of the major problems in cancer treatment is the side effects of the drugs. Nowadays, scientists are developing smart nanocarriers which used for diagnosis and delivering drugs in order to circulate through blood vessels, pass the immune system, attach to cancer cells and kill them without any side effects. In the first research of this thesis, magnetic nanoparticles were coated by modified alginate and used as smart nanocarriers. Magnetic nanocarrier were sysnthesized based on hydrophobic coating of oleic acid and hydrazine oleate-modified alginate shell. The resulting carrier is pH-sensitive and the alginate shell removes in the low pH medium. DOX was placed between hydrophobic chains.... 

Some widely used drugs such as paclitaxel (PTX) are poorly water soluble. The clinical use of PTX with solubilizer causes side effects. These problems limited its application in treatments. In this work has been studied the effect of β-CD-g-PG (HPCD) hybrid nanomaterials, conjugated PG branches onto β-CD core, on the water solubility of PTX. First HPCD has been synthesized. Then the inclusion complex of PTX with HPCD was prepared. The inclusion complex efficiency for PTX:HPCD complex in 1:25 mole ratio was 87%. Then solubility of PTX with HPCD in water has been determined, showing Ap type phase solubility diagram. Then stability constants were calculated. The first order and second order...