Sharif Digital Repository

During femur fracture reduction surgery, both patients and surgeons are exposed to a great amount of radiation, which is harmful to their health. Computer-assisted orthopaedic surgery (CAOS) is a less invasive approach for its ability to reduce the usage of image intensifiers. Various robots have been developed for femur fracture reduction surgery. Most of these robots are based on serial architectures. Both low load-carrying capacity and poor accuracy are inherent to serial robots, which makes them inappropriate for femur fracture reduction. Some parallel robots using the “Stewart platform” have also been developed for femur fracture reduction, but their restricted workspace limits their... 

This work describes the effect of hydroxyapatite with different morphology including nanorods and whisker on the properties of hydroxyapatite/polycaprolactone (HA/PCL) composite. Biodegradable polymer/Hydroxyapatite (HA) composites with the morphology of nanorods and whisker of (HA) as bone replacement scaffolds are synthesized by sol-gel and hydrothermal methods, respectively with a Ca/P ratio of 1.67 and 20:80 (HA/PCL).The crystallization behavior and porosity of HA/PCL composite are studied by scanning electron microscope and X-Ray diffraction. The response of bone marrow-derived human mesenchymal stem cells (hMSCs) in terms of cell proliferation and differentiation to the osteoblastic... 

This investigation presents synthesis and characterization of pure and monophasic hydroxyapatite (Ca10(PO4)6(OH)2; HA) Nanostructures prepared by coral and oyster shell powders heated at 800 oC for 8 h as precursor via precipitation method. The morphology of HA nanostructures was controlled in the presence of various surfactants such as SDS, CTAB and PVP. The HA Nanorods synthesized by SDS were applied to fabricate bone scaffolds. Particle sizes of the HA Nanoparticles were about 20-30 nm. Pours three-dimensional HA/Ge/CMC scaffolds cross-linked by citric and oxalic acids were synthesized. In order to increase the pore size of the scaffolds, NaCl with medium (180-250 µm) and large (420-500... 

The present study is work on fabrication and characterization of a chitosan/ gelatin/ Mg substituted hydroxyapatite nano composite scaffold for bone tissue engineering. At the first step pure and Mg-substituted hydroxyapatite (HA) (Ca10-xMgx(PO4) 6OH2) nano-hexagonal rods with 14–45 nmdiameter.for this, calcium nitrate, magnesium phosphate hydrate and potassium dihydrogenphosphate were used as precursors for Ca, Mg, and P, respectively. Calculated amounts of magnesium ions (Mg+2) especially from 0 to 8% (molar ratio) were incorporated as substituted into the calcium sol solution. Deionized water was used as a diluting media for HA sol preparation and ammonia was used to adjust the pH= 9.... 

In present work, hydroxyapatite nano-rods are synthesized using a simple sol-gel method with calcium nitrate and potassium dihydrogenphosphate as calcium and phosphorus precursors respectively and ammonia was used for adjusting the pH=9. To obtain rod shape hydroxyapaite powder, multi wall carbon nanotubes were added to the solution, nHA powder was calcinated at 60 and 450 ℃. In second step, chitosan-gelatin/nanoHA solution were prepared by blending chitosan and gelatin in different concentrations with nanoHA powder, then the solution was freeze dried to maintain a composite scaffold. The prepared HA powder and bio-composite scaffold were characterized by X-ray diffraction (XRD), field... 

Aseptic loosening and infection are two major problems of bone implants. Aseptic loosening occurs due to poor cell growth and poor adhesion to the implant surface over time. Bone infection at the implant site occurs mainly by the staphylococcus aureus bacteria. In some cases, infection occurs in the short term and in the early times after implantation, and in some cases, infection occurs in later times. The aim of this study is to synthesize and evaluate antibacterial coatings, while having cell growth-promoting components and cell differentiation to solve bone implant problems simultaneously. Also, the issue of bacterial resistance to antibiotics and their risks in bone implants is another... 

Metastatic bone is one of the most common causes pain in cancer patients. Because of Sm-153 emits gamma and beta, Sm-153 have been used for both of the diagnosis and treatment of metastases; Also Tc-99m have been used for the detection of metastases. Dosimetric studies in targeted radiotherapy require an accurate quantification of activity existing in different organs of a patient, which can be estimated from scintigraphic images. Quantitative imaging is difficult to perform because of several physical phenomena, such as scatter and attenuation, which lead to errors in activity determination and nuclear medicine image degradation.
In this work, we must determine the optimal... 

Modified Fish-Bone (MFB) Model and Consistent Generic (CG) Model are simplified Multi-Degrees-of-Freedom (MDOF) models, proven to be valuable tools in estimating seismic demands of moment-resisting frames, aimed to reduce the computational costs by decreasing the number of degrees of freedom. The preliminary expansion of these simplified models for steel moment resisting frames (SMRFs) were proposed by considering elastoplastic behavior and is not able to take into account stiffness and strength deteriorations in nonlinear dynamic behavior of structures. However, behavior deterioration affects seismic demands of SMRFs under intense earthquakes. For this reason, the present study is done to... 

In this thesis, an equivalent MDOF model is proposed for moment frames. On the one hand it is an efficient model for performance-based design and on the other hand makes it possible to perform a large number of nonlinear dynamic analyses. This equivalent MDOF model was obtained through modifying fish-bone model and consequently it was evaluated by subjecting three 5-, 10- and 20-story buildings to 94 earthquake records. Since the conventional performance based design methods utilize equivalent SDOF models derived from push-over analysis, two SDOF models were applied and the advantage of the proposed model compared to the fish-bone model and these two SDOF models was shown.
Four 5-, 10-,... 

Motorized intramedullary nails are a viable solution to treat patients with limb-length inequality. These fully implanted devices use external magnetic actuation to extend. This research examines the conceptual design of this type of nails by investigating various ideas and previous designs. The implant mechanism, body and controller are designed in detail. It was then simulated in standard tests to evaluate it. In addition, the implanted nail undergoes a biomechanical analysis and its stiffness is assessed. Finally, the controller design is carried out using dipole magnetic theory and verified by finite element simulations. As a proof of concept, we made a prototype that is twice the size... 

Cartilage is a connective tissue, whose most important role in the body is to create a surface with a low friction coefficient in order to allow bones to slide on each other without direct contact to transfer loads. Articular cartilage is always under a harsh biomechanical environment and lacks blood, lymphatic and nerve vessels. As a result, it limits the capacity of this tissue to improve and restore itself. According to experimental efforts, cartilage cannot be regenerated spontaneously without the support of healthy subchondral bone. In recent years, the implantation of tissue engineering scaffolds has been considered as an effective strategy for the treatment of osteochondral damage.... 

Hip replacement surgery is performed with the aim of relieving pain and restoring the normal function of the joint for patients who are in the final stages of arthritis. Standard prostheses offered by implant manufacturers come in a wide variety of models and sizes to meet the needs of patients. However, these commercial prostheses may not be suitable for patients with significant bony abnormalities, leading to implant instability and loosening. In such cases, a suitable solution is to use customized implants that are specifically designed to match the patient's unique anatomy. The purpose of this research was to design a customized cement stem for hip joint replacement surgery in patients... 

Millions of people due to factors such as osteoporosis, aging, sports incidents, and accidents face complications from bone fracture injuries every year. Nitinol shape memory alloy and Gyroid metamaterial have attracted researchers to use them as suitable replacements to fill empty areas of broken bones. In this research, numerical modeling and additive manufacturing were used to take advantage of the special properties of both nitinol and gyroid structures. In the modeling section, finite element modeling of the superelastic effect and the one-way shape memory effect of sheet and solid gyroids in cubic and cylindrical geometries with different porosities were done. As a result of the... 

Loosening and gap opening at the bone-implant interface depends on several physiological and mechanical factors such as bone remodeling, stress concentration, and variation in load transfer pathway. Since fracture of orthopedic material at the interface is one of the major failure mode of total joint implants, this study focused on the micromechanical behavior of the interface. Using a two-dimensional FE model, with pure compressive, tensile, and shearing forces applied on bone or cement, ratio of the stress at the interface to the applied stress has been calculated. Stress distribution was considered as a function of porosity,angle of bead contact to surface, as well as size of bead for two... 

BASHTI is a new implant-less ACL reconstruction surgery which has recently been considered for its advantages. This study aimed to investigate the effects of tendon and cannulated drill bit diameter on the BASHTI fixation strength and core bone engaged length (CBEL) in an anterior cruciate ligament (ACL) reconstruction. It is believed that CBEL may affect both bone healing process and fixation strength in this technique. Bovine digital tendons and Sawbones blocks were used to mimic the ACL reconstruction. Tendons were sized to 6, 7, 8, 9, and 10 mm and the hole size for the 6-9 mm tendons was set to 10 mm while for the 10 mm tendon was set to 12 mm. Mechanical strength of the specimens was... 

Bashti Bone Plug Technique (BBPT) is a novel implant-less surgical methodology for Anterior Cruciate Ligament (ACL) reconstruction. The technique uses the core bone plug belonging to the patient, cut during tunneling with hole saw drill bit, to fix the ends of the tendon graft. Results show that when fitting the bone plug in this method, a large strike is required for fixation which leads to breaking the bone plug and consequently reducing the effective length of the bone plug inside the tunnel during fixation. Therefore, it was decided to use the sheath which covers the bone plug to overcome said challenges since during fixation with the sheath, Due to the low friction coefficient in these... 

Shape Memory alloys are a kind of intelligent materials developed in recent years due to their comprehensive use in medical, robotics, and other advanced sciences. Two main characteristics of them are shape memory effect and superelasticity put these materials in the category of advanced materials. Recently, the new branch of them attracted many studies which is the porous shape memory alloys. The importance of this class of material is related to their properties such as bio-compatibility, superelasticity and shape memory effect. Since shape memory alloys are usually expensive, a new field is developed known as functionally graded porosity distribution. This method is performed by... 

Bashti Bone Plug Technique (BBPT) is an implant-less method which can be used in an Anterior Cruciate Ligament (ACL) reconstructive surgery. The technique uses a core bone plug to fix the tendon graft into the bone tunnel. This study investigates the effect of the core bone density on fixation strength in BBPT method. A series of experimental test has been performed to examine the hypothesis of the study. Thirty fresh bovine digital extensor tendon used in three different groups. Sawbones blocks with densities of 160, 240 and 320 kg/m^3 used in substitute of the bone to model the effect of density on the strength of the fixation. The core bone plugs and tunnels created using a custom made... 

Bone is one of the most important biomechanical organs in animal bodies which comprises of a dynamic tissue that can change its internal structure through remodeling process. A comprehensive understanding of this process is of great significance in prevention and cure of many bone diseases. Due to the special conditions of hard bone tissue, empirical studies on the details of bone processes is very costly and time consuming. Thus, mathematical models and in silico simulations are key to unraveling how bone homeostasis imbalance can lead to pathological conditions. Therefore, in the recent years, there has been an increasing interest in modeling bone remodeling process in cellular level. In... 

Since ancient time, healing patients suffering from bone deformities has been one of the most important challenges of physicians. In recent decades, by helping bio mechanic engineers external fixators has been used for this purpose. These fixators divided to parallel and series forms. One of the remarkable merit of parallel external fixators is their high maneuverability. These fixators usually have six degree of freedom, and follow the movement’s pattern of Stewart robots. In this project by studying different fixators which has been commercials, we present two conceptual models of these fixators which three and four legs are used for connecting the lower and upper plates, respectively. The...