Loading...
Search for:
continuous-flows
0.01 seconds
Investigation of 3D Printed Microfluidic System for Continues Drug Synthesis
, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
Abstract
In recent years, batch systems were often used in the synthesis of pharmaceuticals. Nowadays, due to the possibility of more optimal conditions in flow systems, such as better mixing and optimal performance of heat transfer and mass transfer, process safety, reduction of retention time, and ease in increasing the scale of the process, the use of flow systems has been expanded. B-hydroxysulfone is a pharmaceutical intermediate in the production of bicalutamide, which is used in the treatment of prostate cancer and is used in many organic and biological processes. The reaction time in batch systems is about 17 to 20 hours, and in the flow system, the retention time has reached about 180-90...
CFD-Assisted Design of Microreactor and Evaluation for Continuous Drug Synthesis
, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
Abstract
Manufacturing in many industries, such as electronics, petrochemical, automotive, and food, has long relied on continuous approaches, while the pharmaceutical industry has traditionally been processed in batch reactors. Since the beginning of the third millennium, continuous drug synthesis has received attention due to its multiple advantages over batch systems, which include process safety, adaptability, controllability, economic efficiency, scale-up, and enhancing performance. In this project, the pharmaceutical intermediate 1,4-benzodiazepine, which is usable as a precursor of diazepam and flurazepam, is continuously synthesized in a 400 microliters integrated micromixer and microreactor...
Continuous Synthesis of Medicine Utilizing Catalyst Through a Microreactor System
, M.Sc. Thesis Sharif University of Technology ; Kazemeini, Mohammad (Supervisor) ; Khorasheh, Farhad (Supervisor) ; Hosseinpour, Vahid (Co-Supervisor)
Abstract
Nowadays, the use of microreactors is receiving a great deal of attention due to the unique characteristics of such systems, such as high surface-to-volume ratio, low material loss, greater safety, and minimizing mass and heat transfer limitations. In this study, the optimization of the continuous-flow synthesis of Plavix by Cu-MOF heterogeneous catalyst utilizing a glass microreactor was investigated. Structural characteristics of the catalyst were investigated using X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and BET surface area studies to describe the structure and morphology of the catalyst. In order to build...
A new scaling relationship for water imbibition into the matrix: Considering fracture flow
, Article Energy Sources, Part A: Recovery, Utilization and Environmental Effects ; Vol. 36, issue. 12 , Dec , 2010 , p. 1267-1275 ; ISSN: 15567036 ; Shadizadeh, S. R ; Masihi, M ; Sharif University of Technology
Abstract
Spontaneous imbibition of water into the matrix is the most important mechanism for oil recovery in water wet fractured porous media. If the water is in contact with matrix and it is not flowing, the process is called static imbibition. The effect of rock and fluid properties, and boundary conditions on static imbibition are studied and formulated for scaling of the laboratory data to the reservoir scale. In reality, there is a continuous flow in a fracture; incorporating the effect of fracture flow into the scaling formulations is an unresolved issue in the modeling of the capillary imbibition recovery from the matrix. In this article, a new mathematical equation is developed to scale...
Comparison of two methods of iridium impregnation into HZSM-5 in the methanol to propylene reaction
, Article Catalysis Communications ; Volume 16, Issue 1 , 2011 , Pages 150-154 ; 15667367 (ISSN) ; Mohammadrezaei, A ; Asadi, M ; Golhosseini, R ; Naderifar, A ; Sharif University of Technology
2011
Abstract
In this paper, the effects of two methods of iridium impregnation into HZSM-5 on catalyst stability, selectivity for propylene and byproducts in the conversion of methanol to propylene (MTP) were investigated in a continuous flow isotherm fixed-bed reactor. XRD, BET surface area, NH 3-TPD and ICP-AES analytical techniques were applied to define the physical and chemical characteristics of zeolites. The reaction was conducted at 480°C and 1 bar with WHSV = 1 h -1, and with an equal weight percent of methanol and water in the feed. The results revealed that iridium impregnation into HZSM-5 powder led to enhanced propylene selectivity (8%) and catalyst stability while iridium impregnation into...
Dielectrophoretic cell sorting via sliding cells on 3D silicon microelectrodes
, Article Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 22 January 2017 through 26 January 2017 ; 2017 , Pages 147-150 ; 10846999 (ISSN) ; 9781509050789 (ISBN) ; Chan, M. L ; Roshan, K. A ; Yobas, L ; Sharif University of Technology
Abstract
This work presents an innovative design for a flow-through dielectrophoretic cell sorting based on silicon bulk microelectrodes featuring sidewall undercuts. The microelectrodes are configured into an interdigitated array with digits extending across the flow chamber at an oblique angle against the flow stream. Target cells under dielectrophoretic forces and hydrodynamic drag can slide along the digits to a dedicated outlet. The design has been showcased for continuous-flow sorting of viable and non-viable mammalian cells, achieving a throughput of 16,600 cells/min, an order of magnitude higher than those reported for existing continuous-flow cell sorting designs using thin-film or...
Recent approaches to mRNA vaccine delivery by lipid-based vectors prepared by continuous-flow microfluidic devices
, Article Future medicinal chemistry ; Volume 14, Issue 21 , 2022 , Pages 1561-1581 ; 17568927 (ISSN) ; Tavakoli, A ; Mohammadghasemi, H ; Karimi, A ; Ai, J ; Rabiee, M ; Rabiee, N ; Sharif University of Technology
NLM (Medline)
2022
Abstract
Advancements in nanotechnology have resulted in the introduction of several nonviral delivery vectors for the nontoxic, efficient delivery of encapsulated mRNA-based vaccines. Lipid- and polymer-based nanoparticles (NP) have proven to be the most potent delivery systems, providing increased delivery efficiency and protection of mRNA molecules from degradation. Here, the authors provide an overview of the recent studies carried out using lipid NPs and their functionalized forms, polymeric and lipid-polymer hybrid nanocarriers utilized mainly for the encapsulation of mRNAs for gene and immune therapeutic applications. A microfluidic system as a prevalent methodology for the preparation of NPs...