Loading...
Search for: female
0.006 seconds
Total 266 records

    Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems

    , Article Journal of Biomedical Science ; Vol. 21, issue. 1 , July , 2014 ; ISSN: 10217770 Tahamtan, A ; Ghaemi, A ; Gorji, A ; Kalhor, H. R ; Sajadian, A ; Tabarraei, A ; Moradi, A ; Atyabi, F ; Kelishadi, M ; Sharif University of Technology
    Abstract
    Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver HPV-16 E7 DNA vaccine, considered as a tumor specific antigen for immunotherapy of HPV-associated cervical cancer. We have developed a Nano-chitosan (NCS) as a carrier system for intramuscular administration using a recombinant DNA vaccine expressing HPV-16 E7 (NCS-DNA E7 vaccine). NCS were characterized in vitro for their gene transfection ability. Results: The transfection of CS-pEGFP... 

    Silver nanoparticles-polyaniline nanocomposite for microextraction in packed syringe

    , Article Chromatographia ; Vol. 77, issue. 5-6 , 2014 , pp. 397-403 ; ISSN: 00095893 Bagheri, H ; Banihashemi, S ; Sharif University of Technology
    Abstract
    A rapid, convenient and reliable method for microextraction in packed syringe (MEPS) of the loop diuretic furosemide (FUR) in urine along with high-performance liquid chromatography (HPLC) was developed. A nanocomposite based on silver nanoparticles/polyaniline (Ag-NPs/PANI) was synthesized and used as the MEPS packing material. This nanocomposite was prepared conveniently using interfacial polymerization without the need for any templates or functional dopants. The feasibility of the synthesized nanocomposites was examined by isolation of FUR from diluted urine samples. After extraction, the analyte was desorbed by 200 μL of methanol. It was then dried and the residue was dissolved in 30 μL... 

    Disorders of the musculoskeletal system among Tehran, Iranian dentists

    , Article Journal of Musculoskeletal Pain ; Vol. 22, issue. 3 , 2014 , pp. 256-259 ; ISSN: 10582452 Shadmehr, A ; Haddad, O ; Azarnia, S ; Sanamlo, Z ; Sharif University of Technology
    Abstract
    Objectives: Although dental practitioners are confronted with a number of musculoskeletal disorders, relatively few studies have focused on this profession. The aim of this study was to investigate the prevalence of some musculoskeletal complaints of dentists in Iran. Methods: Four hundred and forty-six dentists in Tehran city, Iran were surveyed to determine the prevalence of musculoskeletal problems. We administrated a Persian-language version of the Nordic Questionnaire for this purpose. Results: Data gathered from Iranian dentists showed that most dentists [81%] reported pain in at least one joint. The most prevalent musculoskeletal disorders during the previous 12 months were reported... 

    1H NMR based metabolic profiling in Crohn's disease by random forest methodology

    , Article Magnetic Resonance in Chemistry ; Vol. 52, issue. 7 , July , 2014 , p. 370-376 Fathi, F ; Majari-Kasmaee, L ; Mani-Varnosfaderani, A ; Kyani, A ; Rostami-Nejad, M ; Sohrabzadeh, K ; Naderi, N ; Zali, M. R ; Rezaei-Tavirani, M ; Tafazzoli, M ; Arefi-Oskouie, A ; Sharif University of Technology
    Abstract
    The present study was designed to search for metabolic biomarkers and their correlation with serum zinc in Crohn's disease patients. Crohn's disease (CD) is a form of inflammatory bowel disease that may affect any part of the gastrointestinal tract and can be difficult to diagnose using the clinical tests. Thus, introduction of a novel diagnostic method would be a major step towards CD treatment.Proton nuclear magnetic resonance spectroscopy ( 1H NMR) was employed for metabolic profiling to find out which metabolites in the serum have meaningful significance in the diagnosis of CD. CD and healthy subjects were correctly classified using random forest methodology. The classification model for... 

    Numerical analysis (finite element method) of brace effects on the adolescent idiopathic scoliosis during 24 hours

    , Article Biomedical Engineering - Applications, Basis and Communications ; Vol. 26, issue. 3 , June , 2014 ; 10162372 Gohari, E ; Haghpanahi, M ; Parnianpour, M ; Ganjavian, M. S ; Kamyab, M ; Sharif University of Technology
    Abstract
    In the adolescent idiopathic scoliosis (AIS) treatment, a brace is prescribed to the patients who have 20 to 45° curves on their spines to prevent the disorder's advancement. For the analysis of Milwaukee brace effects during time, finite element models (FEMs) of the spine (the thoracolumbar region) and the ribcage (contained 10 pairs of the ribs and the sternum) were prepared for two patients. For modeling the spine part, a new element was used in which a disc (as viscoelastic 3D beam) and a vertebra (as rigid link) were modeled as an element and the ribs and the sternum modeled by 3D elastic beams. The gravity, Milwaukee brace constraints and the forces of the brace's different regions... 

    Patients' attitudes towards the role of dentists in tobacco cessation counselling after a brief and simple intervention [Attitudes des patients vis-à-vis du rôle des dentistes en matière de conseils dans le sevrage tabagique après une intervention simple et brève]

    , Article Eastern Mediterranean Health Journal ; Vol. 20, issue. 2 , 2014 , p. 82-89 Ebn Ahmady, A ; Homayoun, A ; Lando, H. A ; Haghpanah, F ; Khoshnevisan, M. H ; Sharif University of Technology
    Abstract
    Dental professionals are in a unique position to promote smoking cessation among their patients. We evaluated the effects of a brief counselling intervention by a dentist on patients' attitude towards the role of dentists in tobacco cessation programmes. In a semi-experimental study in Tehran, Islamic Republic of Iran, 70 eligible smokers were selected and randomly assigned to intervention and control groups. The initial attitudes of the patients regarding tobacco cessation counselling services provided by the dentist were determined using a validated questionnaire. The intervention group received a brief chair-side counselling by a dentist based on the 5 A's approach, while no intervention... 

    Normal postural responses preceding shoulder flexion: Co-activation or asymmetric activation of transverse abdominis?

    , Article Journal of Back and Musculoskeletal Rehabilitation ; Vol. 27, issue. 4 , 2014 , p. 545-551 Davarian, S ; Maroufi, N ; Ebrahimi, E ; Parnianpour, M ; Farahmand, F ; Sharif University of Technology
    Abstract
    BACKGROUND AND OBJECTIVES: It is suggested that activation of the transverse abdominis muscle has a stabilizing effect on the lumbar spine by raising intra-abdominal pressure without added disc compression. However, its feedforward activity has remained a controversial issue. In addition, research regarding bilateral activation of trunk muscles during a unilateral arm movement is limited. The aim of this study was to evaluate bilateral anticipatory activity of trunk muscles during unilateral arm flexion.MATERIALS AND METHODS: Eighteen healthy subjects (aged 25 ± 3.96 years) participated in this study and performed 10 trials of rapid arm flexion in response to a visual stimulus. The... 

    The effect of conventional immunosuppressive therapy on cytokine serum levels in pemphigus vulgaris patients

    , Article Iranian Journal of Allergy, Asthma and Immunology ; Vol. 13, issue. 3 , June , 2014 , p. 174-183 ; 17351502 Mortazavi, H ; Esmaili, N ; Khezri, S ; Khamesipour, A ; Farahani, I. V ; Daneshpazhooh, M ; Rezaei N ; Sharif University of Technology
    Abstract
    Pemphigus vulgaris is an autoimmune disease, in which the role of Th17 cytokines needs to be further explored. This study was performed to assess serum levels of three interleukins (IL) required for Th17 differentiation (IL-β, IL-6 and IL-23) and two specific Th17 cytokines (IL- 17 and IL-22) in a group of patients with pemphigus vulgaris, at baseline, 3 weeks and 6 months after of treatment. Correlations between anti-desmogleins and cytokines with disease severity as well as the influence of therapy on the above factors were assessed. Forty-three first-admitted pemphigus vulgaris patients with the active disease entered the study, but only 31 completed the study. Forty-five healthy... 

    Diagnosis of early Alzheimer's disease based on EEG source localization and a standardized realistic head model

    , Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 6 , 2013 , Pages 1039-1045 ; 21682194 (ISSN) Aghajani, H ; Zahedi, E ; Jalili, M ; Keikhosravi, A ; Vahdat, B. V ; Sharif University of Technology
    2013
    Abstract
    In this paper, distributed electroencephalographic (EEG) sources in the brain have been mapped with the objective of early diagnosis of Alzheimer's disease (AD). To this end, records from a montage of a high-density EEG from 17 early AD patients and 17 matched healthy control subjects were considered. Subjects were in eyes-closed, resting-state condition. Cortical EEG sources were modeled by the standardized low-resolution brain electromagnetic tomography (sLORETA) method. Relative logarithmic power spectral density values were obtained in the four conventional frequency bands (alpha, beta, delta, and theta) and 12 cortical regions. Results show that in the left brain hemisphere, the theta... 

    Nonlinear dynamical structure of sway path during standing in patients with multiple sclerosis and in healthy controls is affected by changes in sensory input and cognitive load

    , Article Neuroscience Letters ; Volume 553 , 2013 , Pages 126-131 ; 03043940 (ISSN) Negahban, H ; Sanjari, M. A ; Mofateh, R ; Parnianpour, M ; Sharif University of Technology
    2013
    Abstract
    Although several studies have applied traditional linear measures to evaluate postural control of patients with multiple sclerosis (MS), little is known about the nonlinear dynamics of this patient group. In this study, recurrence quantification analysis (RQA), a well documented nonlinear method, was used to compare the nonlinear dynamical structure of postural sway in two groups consisting of MS patients (. n=. 23) and healthy matched controls (. n=. 23). The study focuses on three levels of postural difficulty consisting of (1) standing on a rigid surface (force platform) with eyes open, (2) standing on a rigid surface with eyes closed, and (3) standing on a foam surface with eyes closed.... 

    NMR based metabonomics study on celiac disease in the blood serum

    , Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue 4 , 2013 , Pages 190-194 ; 20082258 (ISSN) Fathi, F ; Ektefa, F ; Arefi Oskouie, A ; Rostami, K ; Rezaei Tavirani, M ; Mohammad Alizadeh, A. H ; Tafazzoli, M ; Rostami Nejad, M ; Sharif University of Technology
    2013
    Abstract
    Aim: The aim of this study is to look for the proper methods that would be a major step towards untreated CD diagnosis and seek the metabolic biomarkers causes of CD and compare them to control group. Background: Celiac disease (CD) is a common autoimmune disorder that is not easily diagnosed using the clinical tests. Patients and methods: Thirty cases and 30 controls were entered into this study. Metabolic profiling was obtained using proton nuclear magnetic resonance spectroscopy (1HNMR) to seek metabolites that are helpful for the detection of CD. Classification of CD and healthy subject was done using random forest (RF). Results: The obtained classification model showed an 89% correct... 

    Pemphigus vulgaris and infections: A retrospective study on 155 patients

    , Article Autoimmune Diseases ; Volume 2013 , 2013 ; 20900430 (ISSN) Esmaili, N ; Mortazavi, H ; Noormohammadpour, P ; Boreiri, M ; Soori, T ; Vasheghani Farahani, I ; Mohit, M ; Sharif University of Technology
    2013
    Abstract
    Background. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Aim. We aimed to study the prevalence of infection and pathogenic agents in pemphigus vulgaris patients admitted to dermatology service. Material and methods. This retrospective study was conducted on 155 pemphigus vulgaris patients (68 males, 87 females) admitted to dermatology service between 2009 and 2011. In this study, the diagnosis of pemphigus vulgaris was confirmed by light microscopic and direct immunofluorescence findings. Data were collected through a questionnaire. Results. Of 155 pemphigus vulgaris patients, 33 had infection at admission and 9 acquired... 

    A data mining approach for diagnosis of coronary artery disease

    , Article Computer Methods and Programs in Biomedicine ; Volume 111, Issue 1 , 2013 , Pages 52-61 ; 01692607 (ISSN) Alizadehsani, R ; Habibi, J ; Hosseini, M. J ; Mashayekhi, H ; Boghrati, R ; Ghandeharioun, A ; Bahadorian, B ; Sani, Z. A ; Sharif University of Technology
    2013
    Abstract
    Cardiovascular diseases are very common and are one of the main reasons of death. Being among the major types of these diseases, correct and in-time diagnosis of coronary artery disease (CAD) is very important. Angiography is the most accurate CAD diagnosis method; however, it has many side effects and is costly. Existing studies have used several features in collecting data from patients, while applying different data mining algorithms to achieve methods with high accuracy and less side effects and costs. In this paper, a dataset called Z-Alizadeh Sani with 303 patients and 54 features, is introduced which utilizes several effective features. Also, a feature creation method is proposed to... 

    Trajectory of human movement during sit to stand: A new modeling approach based on movement decomposition and multi-phase cost function

    , Article Experimental Brain Research ; Volume 229, Issue 2 , 2013 , Pages 221-234 ; 00144819 (ISSN) Sadeghi, M ; Andani, M. E ; Bahrami, F ; Parnianpour, M ; Sharif University of Technology
    2013
    Abstract
    The purpose of this work is to develop a computational model to describe the task of sit to stand (STS). STS is an important movement skill which is frequently performed in human daily activities, but has rarely been studied from the perspective of optimization principles. In this study, we compared the recorded trajectories of STS with the trajectories generated by several conventional optimization-based models (i.e., minimum torque, minimum torque change and kinetic energy cost models) and also with the trajectories produced by a novel multi-phase cost model (MPCM). In the MPCM, we suggested that any complex task, such as STS, is decomposable into successive motion phases, so that each... 

    Fatal accident distribution by age, gender and head injury, and death probability at accident scene in Mashhad, Iran, 2006-2009

    , Article International Journal of Injury Control and Safety Promotion ; Volume 20, Issue 2 , 2013 , Pages 121-133 ; 17457300 (ISSN) Zangooei Dovom, H ; Shafahi, Y ; Zangooei Dovom, M ; Sharif University of Technology
    2013
    Abstract
    Several studies have investigated road traffic deaths, but few have compared by road user type. Iran, with an estimated 44 road traffic deaths per 100,000 population in 2002 had higher road traffic deaths than any other country for which reliable estimates can be made. So, the present study was conducted on road death data and identified fatal accident distribution by age, gender and head injury as well as the influences of age and gender on deaths at accident scenes for all road user groups. Data used in this study are on fatal road accidents recorded by forensic medicine experts of the Khorasan Razavi province in Mashhad, the capital of the province, the second largest city and the largest... 

    Discrimination of bilateral finger photoplethysmogram responses to reactive hyperemia in diabetic and healthy subjects using a differential vascular model framework

    , Article Physiological Measurement ; Volume 34, Issue 5 , 2013 , Pages 513-525 ; 09673334 (ISSN) Keikhosravi, A ; Aghajani, H ; Zahedi, E ; Sharif University of Technology
    2013
    Abstract
    Endothelial dysfunction assessment has received considerable attention due to its potential in early screening of cardiovascular diseases. Since the seminal work by Celermajer in flow-mediated dilation (FMD) based on B-mode ultrasound measurement of the brachial artery dilation following limb ischemia, many attempts have been made toward applying this method to clinical, non-invasive endothelial dysfunction assessment. One major obstacle toward achieving this objective has been the relative high cost of the required setup and skilled manpower. Such limitations have prompted the investigation of other non-invasively accessible signals such as the photoplethysmogram (PPG) in relation to FMD.... 

    The concentration of serum zinc in celiac patients compared to healthy subjects in tehran

    , Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue 2 , 2013 , Pages 92-95 ; 20082258 (ISSN) Fathi, F ; Ektefa, F ; Tafazzoli, M ; Rostami, K ; Nejad, M. R ; Fathi, M ; Rezaye Tavirani, M ; Oskouie, A. A ; Zali, M. R ; Sharif University of Technology
    2013
    Abstract
    Aim: This study evaluated serum levels of zinc in patient with CD compare to healthy subjects. Background: Celiac disease (CD) is characterized by small intestinal malabsorption of nutrients as a consequence of ingestion of wheat gluten. Zinc is an essential trace element that it has vital biological functions. Patients and methods: Sera of 30 celiac cases and 30 healthy normal cohorts as control group were obtained. Atomic absorption spectrophotometer was employed for estimating serum zinc level. Results: Zinc concentrations in patients diagnosed with CD were significantly lower than healthy subjects (75.97±12 compared with 92.83±18, P-value < 0.0001). Conclusion: The result of this study... 

    Validation of the revised stressful life event questionnaire using a hybrid model of genetic algorithm and artificial neural networks

    , Article Computational and Mathematical Methods in Medicine ; Volume 2013 , 2013 ; 1748670X (ISSN) Sali, R ; Roohafza, H ; Sadeghi, M ; Andalib, E ; Shavandi, H ; Sarrafzadegan, N ; Sharif University of Technology
    2013
    Abstract
    Objectives. Stressors have a serious role in precipitating mental and somatic disorders and are an interesting subject for many clinical and community-based studies. Hence, the proper and accurate measurement of them is very important. We revised the stressful life event (SLE) questionnaire by adding weights to the events in order to measure and determine a cut point. Methods. A total of 4569 adults aged between 18 and 85 years completed the SLE questionnaire and the general health questionnaire-12 (GHQ-12). A hybrid model of genetic algorithm (GA) and artificial neural networks (ANNs) was applied to extract the relation between the stressful life events (evaluated by a 6-point Likert scale)... 

    A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance

    , Article Magnetic Resonance in Chemistry ; Volume 51, Issue 2 , DEC , 2013 , Pages 102-109 ; 07491581 (ISSN) Mehrpour, M ; Kyani, A ; Tafazzoli, M ; Fathi, F ; Joghataie, M. T ; Sharif University of Technology
    2013
    Abstract
    Multiple sclerosis (MS) is a nervous system disease that affects the fatty myelin sheaths around the axons of the brain and spinal cord, leading to demyelination and a broad range of signs and symptoms. MS can be difficult to diagnose because its signs and symptoms may be similar to other medical problems. To find out which metabolites in serum are effective for the diagnosis of MS, we utilized metabolic profiling using proton nuclear magnetic resonance spectroscopy (1H-NMR). Random forest (RF) was used to classify the MS patients and healthy subjects. Atomic absorption spectroscopy was used to measure the serum levels of selenium. The results showed that the levels of selenium were lower in... 

    Multijoint coordination during sit-to-stand task in people with non-specific chronic low back pain

    , Article Biomedical Engineering - Applications, Basis and Communications ; Volume 25, Issue 1 , 2013 ; 10162372 (ISSN) Tajali, S ; Negahban, H ; Shaterzadeh, M. J ; Mehravar, M ; Salehi, R ; Narimani, R ; Parnianpour, M ; Sharif University of Technology
    2013
    Abstract
    Sit-to-stand (STS) is an important functional task affected by low back pain (LBP). It requires fundamental coordination among all segments of the body to control important performance variables such as body's center of mass (CM) and head positions. This study was conducted to determine whether LBPs could coordinate their multiple joints to achieve the task stability to the same extent as healthy controls. About 11 non-specific chronic LBP and 12 healthy control subjects performed STS task at three postural difficulty levels: rigid surface - open eyes (RO), rigid surface - closed eyes (RC) and narrow surface - closed eyes (NC). Motion variability of seven body segments, CM and head positions...