Sharif Digital Repository

Ion channels are present in all cell membranes which are the important part of the performances in regulating the flow across the membrane as well as the signaling. We have investigated the water permeation through carbon nanotube (CNT) membranes as a model for the synthetic ion channels, i.e. peptide nanotube channels (PNCs). The effect of different charge configured CNTs which tailored based on these ion channels on the water permeation has been studied. In addition, the temperature dependence of the permeation using statistical models such as continuous time random walk model (CTRW) via molecular dynamics simulation has been investigated. We have found that there is a jump in the... 

Recently, the nano-bio communication networks have received significant attention. Among different communication mechanisms proposed for nano communication, diffusion based molecular communication (DMC) is the most promising scheme. This thesis focuses on DMC and first proposes a theoretical model for this scheme. In the next part of the thesis, inspired by the molecule transport mechanisms in the biological cells, two biosynthetic modulator structures are proposed.In first structure, an ion channel based modulator for DMC is proposed which controls the rate of molecule release from the transmitter by modulating a gating parameter signal. The corresponding average modulated signal, i.e., the... 

Quantum Theory leads to results that are consistent with the very high accuracy with experience and also includes a wide range of empirical phenomena. Hence, quantum mechanics is accepted as the best and most acclaimed physical theory. However, there is still no consensus between physicists on the interpretation of parts of this theory. One of the unresolved issues in quantum mechanics is the measurement problem. The basis of the measurement problem is a kind of transition from the quantum world to the classical world. The fundamental question that arises here is, where is the boundary between quantum mechanics and classical mechanics? and how can be described the transition from quantum... 

Mechanosensitive (MS) channels are ubiquitous molecular force sensors that respond to a number of different mechanical stimuli including tensile, compressive and shear stress. One of the main mechanisms to functionally study these channels is the patch clamp technique. Here we use continuum mechanics to probe the question of how curvature, in a standard patch clamp experiment, at different length scales (global and local) affects a model MS channel. Firstly, to increase the accuracy of the Laplace’s equation in tension estimation in a patch membrane and to be able to more precisely describe the transient phenomena happening during patch clamping, we propose a modified Laplace’s equation. In...