Sharif Digital Repository

This work presents an innovative design for a flow-through dielectrophoretic cell sorting based on silicon bulk microelectrodes featuring sidewall undercuts. The microelectrodes are configured into an interdigitated array with digits extending across the flow chamber at an oblique angle against the flow stream. Target cells under dielectrophoretic forces and hydrodynamic drag can slide along the digits to a dedicated outlet. The design has been showcased for continuous-flow sorting of viable and non-viable mammalian cells, achieving a throughput of 16,600 cells/min, an order of magnitude higher than those reported for existing continuous-flow cell sorting designs using thin-film or... 

Biocompatible porous polymeric scaffolds provide a suitable environment for proliferation of stem cells in human body. In this research work, porous gelatin–poly(ethylene glycol), PEG, based scaffolds were prepared using combination of freeze-gelation and freeze-extraction methods. Effects of various parameters such as freezing temperature, cross-linking agent, concentrations of gelatin and PEG and their blending ratio on physical and mechanical properties, swelling ratio, porosity, pore size, and degradation rate of scaffolds were investigated. Also, proliferation of fibroblast skin cells on the scaffolds was examined by MTS assay to assess the suitability of the scaffolds in wound healing... 

Magnetic carbon nanotubes (MCNTs) have been widely studied for their potential applications in medicine, diagnosis, cell biology, analytical chemistry, and environmental technology. Introduction of MCNTs paved the way for the emergence of new approaches in nanobiotechnology and biomedicine as a result of their multifarious properties embedded within either the carbon nanotubes (CNTs) or magnetic parts. Numerous preparation techniques exists for functionalizing CNTs with magnetic nanoparticles, and these versatile strategies lay the ground for the generation of novel and versatile systems which are applicable to many industries and biological areas. Here, we review and discuss the recent... 

Oxidative stress has been implicated in the progression of age-related macular degeneration (AMD). Treatment with antioxidants seems to delay progression of AMD. In this study, we suggested an antioxidant delivery system based on redox-sensitive liposome composed of phospholipids and a diselenide centered alkyl chain. Dynamic light scattering assessment indicated that the liposomes had an average size of 140 nm with a polydispersity index below 0.2. The percentage of encapsulation efficiency of the liposomes was calculated by high-performance liquid chromatography. The carriers were loaded with N-acetyl cysteine as a model antioxidant drug. We demonstrated responsiveness of the nanocarrier... 

A hybrid model based on the flow function and dislocation cell structure model by considering the Taylor assumption is utilized to model the dislocation structure evolution, cell size and mechanical properties of OFHC in severe plastic deformation. Here, the ECAP is chosen as a process of severe plastic deformation. In this study, the model is modified by taking the value of cell size coefficient as a function of strain and considering two different values of dynamic recovery coefficients of cell walls and cell interiors. These modifications lead to achieve the more accurate modeling results. From the flow function the strain rate distribution are achieved and then using the model the... 

Electroporation is permeabilization of the cell membrane, caused by an external electric field. Because of minimal thermal effects and minimal disturbance caused to tissue vasculature electroporation is becoming one of the methods of choice in tumor therapy. There has been no report indicating that reversible electroporation can be detected by ultrasound. In this work a cellular model for monitoring the electroporation process b; ultrasound RF signals is proposed. The density of aqueous pores with different sizes was found by applying the asymptotic model of electroporation and Smoluchowski equation. The cellular model was send to an ultrasound simulation program where pores were modeled by... 

SRAM cell stability assessment is traditionally based on static criteria of data stability requiring three coincident points in DC butterfly curves. This definition is based on static (DC) characteristics of the cell transistors. We introduce the dynamic criteria of cell data stability knowing that the cell operates in a dynamic environment alternating between access and non-access conditions. The proposed definition of the dynamic data stability criteria introduces a new bound for the cell static noise margin (SNM). It reveals that the true noise margin of the cell can be made considerably higher than the conventional SNM once the cell access time is sufficiently shorter than the cell... 

Based on the observation that dynamic occurrence of zeros in the cache access stream and cache-resident memory values of ordinary programs exhibit a strong bias towards zero, this paper presents a novel CMOS four-transistor (4T) SRAM cell for very high density and low power cache applications. This cell retains its data with leakage current and positive feedback without refresh cycle. The new cell size is 20% smaller than a conventional six-transistor cell using same design rules and delay access of a cache based on new 4T SRAM cell is 32% smaller than a cache based on 6T SRAM cell. Also the dynamic and static power consumption of new cell is 40% and 20% smaller than 6T SRAM cell,... 

Based on the observation that dynamic occurrence of zeros in the cache access stream and cache-resident memory values of ordinary programs exhibit a strong bias towards zero, this paper presents a novel CMOS five-transistor SRAM cell (5T SRAM cell) for very high density and low power cache applications. This cell retains its data with leakage current and positive feedback without refresh cycle. Novel 5T SRAM cell uses one word-line and one bit-line and extra read-line control. The new cell size is 17% smaller than a conventional six-transistor SRAM cell using same design rules with no performance degradation. Simulation and analytical results show purposed cell has correct operation during...