Sharif Digital Repository

Due to the increasing need of use of drugs and insufficient efficiency of conventional methods, drug delivery systems has gathered a lot of interests. There are different systems existing for controlled drug delivery, among which is implementation of hydrogel microparticles (microgels) as carriers with high potential. The most important factor in these systems is size distribution of drug-carrying microgels and a narrow size distribution leads to a controlled and suitable release. Due to unique characteristics of microfluidic systems, significant focus has been placed on them nowadays for production of microgels with suitable morphology and narrow size distribution. Therefore, in this study... 

The main goals of this research are design, simulation, and fabrication of a microfluidic system working based on dielectrophoresis. This research divided into two different parts, the first of which is the simulation of a microfluidic system, and second of which is an attempt for fabrication of microfluidic system. For the fabrication of the microfluidic system, different methods were used. In the simulation part, the enrichment of different particles was investigated, and the effects of different parameters on the enrichment were assessed. It was observed that as flow rate increases, the enrichment amount diminishes. Furthermore, as the microfluidic depth decreases, the enrichment amount... 

Recent developments in MEMS related areas have increased the demand for practical and novel pumping methods. Utilizing Electroosmotic force for flow generation in microchannels has become really popular recently, because of its reliable operation and control. One of potential applications of MEMS devices is biological and medical analysis which most samples are considered to be non-Newtonian; consequently, thermal transport characteristics of non-Newtonian electroosmotic flow of power-law fluids is investigated in this paper. In this study, thermal and hydrodynamic behavior of non-Newtonian electroosmotic flow of power-law model in a slit microchannel is analyzed. It is assumed that the flow... 

Electroosmosis is the predominant mechanism for flow generation in lab-on-a-chip devices. These microfluidic devices are microscale laboratories on a microchip that can perform clinical diagnoses. Since most biofluids encountered in these devices are considered to be non-Newtonian and the cross section of microchannels in these devices is close to a rectangular shape, In this study, the hydrodynamically and thermally fully developed combined electroosmotically and pressure driven flow of power-law fluids in rectangular microchannels is analyzed. The governing equations are first made dimensionless and then transformed into new ones based on the computational parameters which provide mesh... 

The lab-on-a-chip (LOC) devices utilizing electroosmosis for flow actuation are usually encountered with non-Newtonian behavior of working fluids. Hence, studying the flow of non-Newtonian fluids under an electroosmotic body force is of high importance for accurate design and active control of these devices. In this thesis, mixed electroosmotically and pressure driven flow of salivathrough a rectangular microchannel is examined utilizing two viscoelastic constitutive equations, namely PTT and FENE-P models. Since the hydrodynamic entry length is usually negligible for microflows, a hydrodynamically developed flow is considered in the analysis. The governing equations in dimensionless form... 

According to statistics in 2012, around 14 million people worldwide have cancer, and 8 million have died that year, according to estimates, this number will increase to 21 millions new cancer case and 13 million mortality in 2030. Despite years of research on cancer, many questions about the mechanism of the spread of cancer in the body remain unanswered so far. The proposed models identify that the cells isolated from the primary tumor and transmit them to the circulatory system in the form of circulating tumor cells (CTCs) or in the form of clusters as responsible for the incidence of cancer. This process is called metastasis. Recent studies have reported the high potential of metastasis... 

Infertility is a growing global issue with significant psychological, economic, and social consequences, which among them, male factor infertility problems make up a considerable portion. The conventional methods of sperm separation inclusive of density-gradient centrifugation and swim-up with numerous problems contain DNA fragmentation and low yield, and both of the methods are not effective for samples with low sperm counts. Modern microfluidic systems are trying to improve this problem by increasing the quality of the isolated sperms. However, most of these systems rely solely on sperm motility as a separation mechanism, which is not a sufficient condition for the separated sperm to be... 

Nowadays, microgyroscopes are among the most important products of MEMS. The production of small, precise and inexpensive gyroscopes has become possible as the result of recent developments in fabrication technology. In this thesis it is intended to introduce a new method for manufacturing more precise microgyroscopes regarding manufacture facilities. Using this new method, sensitivity and resistance of microgyroscopes are increased against noises which are primarily caused by vibration and rotation about undesirable axes. The rotational movement imposed on the gyro is detected through fluid flow within its torus channel. This transformation facilitates the measurement of the initial motion....