Sharif Digital Repository

Blood is one of the most important biological organs. Red blood cell (RBC), as the most abundant cell of blood, plays an important role at life of the living bodies. Unique mechanical properties of RBCs enable them to pass through very narrow vessels. Any abnormality in these mechanical properties will disorder the function of the cell and many diseases affect these properties too. Studying the mechanical properties of RBCs is very importantin that it could result in a disease diagnostic method in a single-cell level. In this thesis we have tried to measure the viscoelastic properties of a single RBC by an optical trap through a passive method. This measurement is made through studying the... 

The success of matrix acid production operations and its proper efficiency is one of the main challenges for oil and gas companies. The heterogeneity of the reservoir formation (especially the permeability difference) in the area around the well due to the presence of different reservoir layers results in the non-uniform distribution of acid among them and adds acidizing challenges. In order to improve production conditions, stimulation fluid transfer to the low permeability layer, which is the main target of acidizing. In this study, a new generation of chemical diverter, called Viscoelastic Surfactant, has been used. These materials have two components of elastic and viscous behavior, and... 

Now a days, the ability of measuring the mechanical properties of the living cells in in experiments has been increased. Experiments shows that the stem cells could alter their faith in different mechanical situations, but an integrated model about this phenomenon in literature has not been introduced yet. In this research thesis s minimal cell model (MMC) is developed to capture the behavior of the cells on substrates with varying mechanical properties and morphologies, MMC consists of large scale models for outer membrane of the cell and nuclear envelope, cytoplasmic area, chromatin fibers and Extra cellular matrix. Each component of the MMC will be placed in an integrated software to... 

Red blood cells are one of the most important parts of blood and their mechanical properties are so important in some diseases. Red blood cell is mostly consisted of membrane, cell skeleton, and cytoplasm which contains hemoglobin proteins. Studying these properties separately not only could give us pieces of information about cell mechanics, but also reveals a way to predict their behavior after illnesses. Optical tweezers as a tool, which can produce and measure Piconewton to Nanonewton forces, has been interesting in red blood cell parts' studying. In this thesis, at first hemoglobin is taken out gradually by using Saponin (which is enable to make some pores in the membrane) and the... 

Due to adverse health problems with lumbar spine among professional drivers associated with exposure to whole body vibration (WBV), studying the effect of vibrations and parameters influencing WBV is of great importance. This study aims to simulate whole body vibration for a ground vehicle occupant and calculate loads that lumbar spine tolerate during harmonic sinusoidal vibrations. Moreover, this study determines the effect of lumbar spine angle, seat specifications (angles and materials), and vibration frequency on the results. To this end, a detailed viscoelastic lumbar spine (L1-S1) has been modeled using FE method which has been replaced with the simplified spine model in HYBRID III... 

FE simulations have been widely used to investigate the response of the brain tissue in various circumstances. The accuracy of the material models critically affects the results of the numerical simulation. However, despite the numerous studies aiming for the material modeling of the brain, there is still divergence between the results reported in the literature. A part of this discrepancy is due to the inherent difference between samples. Nonetheless, another part of it is resulted from the differences between testing protocols used by researchers. In some protocols multiple mechanical tests are performed on each sample. Enough recovery time should be considered between consecutive test... 

Viscoelastic properties of biological fluid play an important role on biological organs. As an example we all know that Red blood cells must have high flexibility to pass thorough thin capillary.This high flexibility come partially from cytoplasm and 2 dimensional membrane and partially from polymeric fluid inside the cell(hemoglobin). So, for recognizing mechanical properties of a whole cell we also need to study the same properties just for fluid inside the cell. for this general purpose through this project we are going to measure viscoelastic properties of any polymeric fluid by optical tweezers which has an ability for measuring displacement of micron particle with accuracy of nm. first... 

In this study, the linear dynamic response of an inclined FGM Timoshenko beam on linear viscoelastic foundation subjected to a traveling mass with constant and variable velocity is investigated. Timoshenko beam theory and von-karman strain-displacement relations are utilized to model the problem. the FGM beam is made of metal and ceramic and it is assumed that material properties of the beam vary continuously in the thickness direction according to the exponential law and the power-law form. The kelvin-voigt damping model is applied to model the internal damping of the FGM beam. The partial differential equations of motion for the bending rotation of cross-section, longitudinal and... 

Due to the limitations on experiments in the field of cell mechanics, computational modeling of biological cells have attracted attention within two recent decades. In general, some models have been developed in two different scales, known as microstructure and continuum, both of which have their own pros and cons. Nevertheless, viscoelastic behavior of cell membrane has attracted less attention of scientists up to now. Therefore, multi-scale simulation of the viscoelastic behavior of the cell membrane has been chosen as the main goal of this thesis. Toward this goal, at first the energy of the simulation box, consisting of 128 Dipalmitoylphosphatidylcholine and 3655 water molecules, was... 

This thesis was conducted both numerically and experimentally. In the experimental investigations aqueous solutions of high molecular weight Carboxymethylcellulose (CMC) was used. The experimental set-up was composed of a glass syringe, and a piston which can easily move through the syringe. Different die with aspect ratio ranging from 5.25 to 28.8 can be attached to the syringe. The syringe then is filled with the CMC solution with different weight fractions. Then using a force exerting on the piston, the solution comes out of the die and exiting velocity was calculated from weight of CMC solution that exit from die in a definite time. High quality photographs were taken from extrudate... 

In this thesis the effects of vibro absorbing coating on vibration behavior of an aluminum sheet and also on a stiffened aluminum panel are investigated using experimental approach. Since there wasn't any information available about the used coating, to find its viscoelastic material properties, the method mentioned in ASTM E756-05 standard is employed and corresponding tests are performed.
In the next step, an analytical solution developed for the aluminum sheet with viscoelastic coating and the obtained results compared with experimentation, in order to find its prediction accuracy for loss in “loss factor” of the system in presence of coating.
To study the effect of... 

Cell migration plays a key role in many biological processes including metastasis, wound healing, inflammatory response, body immune response and formation of new blood vessels. The migration of cells in response to the gradient of concentration gradient is regarded as chemotaxis. In the present study, the group chemotaxis of endothelial cells is simulated in response to gradient concentration of biochemical species using a developed cell migration model. At the first step, the numerical simulation of fluid flow and concentration transport of biochemical species is performed using a developed FVM code. At the second part, a model is developed to mimic the group migration of endothelial... 

In many cases, oil and gas extraction from reservoirs due to damage and permeability reduction near wellbore is lower than optimum level and reduces the flow of oil into the well. In fact, formation damage is the collapse of natural condition of reservoirs, In addition to delaying production and increasing costs, it causes early desertification of wells. Well stimulation methods are used to solve this problem and increase production. One of the most effective ways to increase the production of wells is well acidizing. In this study, the acid performance of the fractured carbonate reservoirs has been investigated. In this type of reservoirs, due to the existence of high permeable paths of the... 

Taghizadeh Manzari, M. (In this work, a modified Smoothed Particle Hydrodynamics (SPH) method, with a new moving solid boundary treatment approach, is utilized to simulate the particulateflow problems. The renormalized first and second derivative schemes which lead tothe consistency of the method, are also used along with a modification to the continuityequation which prevents the spurious pressure oscillations. The proposed methodis validated by solving benchmark problems of solid body motion in channel flows.There is a good agreement between the obtained results and those reported in theliterature. The convergence of solutions for different domain discretizations is alsoassessed. In order... 

With the transportation progress and appearance of transit industry, necessity of modern vehicles redounded to appearance of heavier trucks with higher speeds, moving on the roads. In addition, with the progress in mechanical engineering and automobile industry, appearance of such trucks is growing increasingly. So, bridges as one of the structures that civil engineers design and construct, nowadays are subjected to higher moving dynamic loads in comparison with the past. As a result, lots of investigation and researches in the universities and institutions all over the world are being conducting on the effects of the vehicle speeds on the dynamic stresses of the bridges. Bridge codes... 

This study presents the aeroelastic stability and vibration analysis of a sandwich circular cylindrical shells with a constrained viscoelastic layer. Based on the Donnell-Moshtari theory, the structural formulation of the cylinder is obtained using Lagrange method. The Rayleigh-Ritz method is implemented to solve the discretized governing equations. To describe the mechanical properties of the viscoelastic layer, the fractional order standard solid model is applied. The effects of variation of the governing parameters such as the length to radius ratio, radius to total thickness ratio and ratio of core to facing thickness on the stability margins and frequencies of sandwich cylindrical... 

In this research, the effect of application of viscoelastic material with fractional derivatives pattern in aeroelastic stability analysis for a sandwich wing, has been examined. In order to study the wing’s aeroelastic behavior and the effect of inner layer on aeroelastic instability boundaries (fluttering), the wing is modeled as a cantilever sandwich beam with a fractional viscoelastic core. The Wagner approximation is used for applying the unstable aeroelastic loads. To obtain the characteristics and behaviors of the structure some assumptions including non-classical effects, are considered. These non-classical effects are the inner layer shear stress, the axial movements, the wing’s... 

Friction composites, as a part of vehicle safety system, should hold some characteristics such as high wear resistance, low weight, durability, low noise, stable friction coefficient, availability and low price. It is very interested to use mixture of rubber and resin in friction materials to reach good properties of both rubber and resin simultaneously. This mixture is especially used in railway’s brake pads. Fibrous reinforcement is another important ingredient in friction composites. Asbestos used to be the most significant fibrous reinforcement due to its appropriate tribological specifications but the recent ban on asbestos by environmental protection agency has forced the friction... 

The lab-on-a-chip (LOC) devices utilizing electroosmosis for flow actuation are usually encountered with non-Newtonian behavior of working fluids. Hence, studying the flow of non-Newtonian fluids under an electroosmotic body force is of high importance for accurate design and active control of these devices. In this thesis, mixed electroosmotically and pressure driven flow of salivathrough a rectangular microchannel is examined utilizing two viscoelastic constitutive equations, namely PTT and FENE-P models. Since the hydrodynamic entry length is usually negligible for microflows, a hydrodynamically developed flow is considered in the analysis. The governing equations in dimensionless form... 

In this thesis, the dynamic behavior of a pinned-pinned fractional viscoelastic pipe conveying fluid is examined in the external cross flow. The Galerkin method is employed to discretize the nonlinear coupled equations of motion for viscoelastic pipe conveying fluid in the external cross flow. Consequently, four modes of system are obtained. In addition, direct perturbation method of multiple scale is used to solve the governing nonlinear coupled equations of motion for the fractional viscoelastic pipe conveying pulsating fluid in the external cross flow. Moreover, time response diagrams are drawn in order to investigate under effects of the internal fluid velocity, external fluid reduced...