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Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures
, Article International Journal of Pharmaceutics ; Volume 629 , 2022 ; 03785173 (ISSN) ; Mohsen Dehnavi, S ; Ahmadi Seyedkhani, S ; Yahya Rahnamaee, S ; Golizadeh, M ; Sharif University of Technology
Elsevier B.V
2022
Abstract
In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80–110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5–20 nm Ag nanoparticles. MTT assay...
A new approach for simultaneously improved osseointegration and antibacterial activity by electrochemical deposition of graphene nanolayers over titania nanotubes
, Article Applied Surface Science ; Volume 580 , 2022 ; 01694332 (ISSN) ; Bagheri, R ; Vossoughi, M ; khafaji, M ; Asadian, E ; Ahmadi Seyedkhani, S ; Samadikuchaksaraei, A ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Simultaneous enhancement of osseointegration and bacterial infection prohibition through surface modifications is a challenging but promising approach to achieve durable implantation. To that end, we present a multifunctional surface coating composed of graphene nanolayers and hierarchical well-aligned TiO2 nanotubes with a nanoporous top layer (cRTNT). FESEM studies reveal tunable increasing island morphologies of graphene nanolayers (G) on cRTNT by a cyclic voltammetry process. XPS analysis shows that the enhanced interface chemistry is due to TiO2-carbon bonding. The roughness of the sample containing a medium amount of graphene, cRTNT-75%GO, was calculated ∼289 nm, which was 543% higher...
Fabrication of Dental Implant from Ti-6Al-4V With Nanostructured Hydroxyapatite Coating
, M.Sc. Thesis Sharif University of Technology ; Sadrnezhad, Khatiboleslam (Supervisor)
Abstract
The use of dental implants has grown considerably in recent years in Iran but this piece is the industrial imported parts that are not yet produced in Iran. So the main purpose of this research was to fabricate a dental implant from Ti-6Al-4V alloy by CNC machining techniques. On the other hand, the poor bonding strength of bioactive coatings and low cell growth on the surface of uncoated implants are the common problems in the use of dental implants. So another aim of this study was to investigate the effect of Nanoscale surface topography and nanostructured coatings on the surface modification of titanium implant in order to improve Osseointegration and the bonding strength of bioactive...
An Abstract Model for Perso-Arabic Typography
, M.Sc. Thesis Sharif University of Technology ; Tabesh, Yahya (Supervisor)
Abstract
In this research, we provide an abstract model for the typography of Persian language (Perso-Arabic script) and study two text corpora based on the Unicode properties of characters and this model. Then we search the corpora for phrases with special properties, based on the abstract model
A Novel Magnetic Molecularly Imprinted Polymers Nanoparticle as Extracting Medium For Micro-Solid Phase Extraction
, M.Sc. Thesis Sharif University of Technology ; Bagheri, Habib (Supervisor)
Abstract
This thesis cantain two section. In the first section a novel extracting medium based on magnetic molecularly imprinted polymers (MIPs) nanoparticles was synthesized by chemical polymerization for micro-solid phase extraction. In this work, the modified chitosan magnetite nanoparticles (MNP-CS) was synthesized by co-precipitating Fe2+ and Fe3+ in the chitosan solution [1,2]. The characteristic properties of Fe3O4@MIPs nanoparticles were determined using Fourier transform infrared spectrometer. Extraction efficiency of the novel extracting medium was compared with MNP-CS sorbents for the determination of RhB in aqueous samples, via quantification by spectrofluorimetry. The obtained results...
Bioinspired multifunctional TiO2 hierarchical micro/nanostructures with tunable improved bone cell growth and inhibited bacteria adhesion
, Article Ceramics International ; Volume 46, Issue 7 , 2020 , Pages 9669-9679 ; Bagheri, R ; Vossoughi, M ; Ahmadi Seyedkhani, S ; Samadikuchaksaraei, A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
Two main origins of failure for hard tissue replacements are structural loosening and prosthetic implant infections (PIIs). Bioinspired multifunctional TiO2 hierarchical micro/nanostructures of conical-shaped TiO2 (CTO), regular TiO2 nanotubes (RTO) and irregular TiO2 nanotubes (ITO) with tunable improved cell growth and inhibited bacteria adhesion were synthesized. CTO and ITO samples indicated superhydrophilicity with contact angles of less than 5°. The MTT assay demonstrated excellent biological performance for RTO and CTO sample with 98.1% and 103.1% of cell viability, respectively. The bridging force for osteoblast cell attachment onto the synthesized porous coatings was presented as a...
Site-specific protein conjugation onto fluorescent single-walled carbon nanotubes
, Article Chemistry of Materials ; Volume 32, Issue 20 , 2020 , Pages 8798-8807 ; Wu, S. J ; Rahnamaee, S. Y ; Schuergers, N ; Boghossian, A. A ; Sharif University of Technology
American Chemical Society
2020
Abstract
Semiconducting single-walled carbon nanotubes (SWCNTs) are among the few photostable optical emitters that are ideal for sensing, imaging, drug delivery, and monitoring of protein activity. These applications often require strategies for immobilizing proteins onto the nanotube while preserving the optical properties of the SWCNTs. Site-specific and oriented immobilization strategies, in particular, offer advantages for improving sensor and optical signaling responses. In this study, we demonstrate site-specific protein immobilization of a model of enhanced yellow fluorescent protein with a single engineered cysteine residue, using either single-stranded DNA or a pyrene-containing linker to...
Nanofibrillated chitosan coated highly ordered titania nanotubes array/graphene nanocomposite with improved biological characters
, Article Carbohydrate Polymers ; Volume 254 , 2021 ; 01448617 (ISSN) ; Bagheri, R ; Heidarpour, H ; Vossoughi, M ; Golizadeh, M ; Samadikuchaksaraei, A ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Designing multifunctional surfaces is key to develop advanced materials for orthopedic applications. In this study, we design a double-layer coating, assembled onto the completely regular titania nanotubes (cRTNT) array. Benefiting from the biological and topological characteristics of chitosan nanofibers (CH) and reduced graphene oxide (RGO) through a unique assembly, the designed material features promoted osteoblast cell viability, prolonged antibiotic release profile, as well as inhibited bacterial biofilm formation. The synergistic effect of RGO and CH on the biological performance of the surface is investigatSed. The unique morphology of the nanofibers leads to the partial coverage of...
Study and Preparation of Paper Filter for Air Treatment in Internal Combustion Process
, M.Sc. Thesis Sharif University of Technology ; Musavi, Abbas (Supervisor) ; Hamzeh, Yahya (Supervisor)
Abstract
Air filter paper is a combination of cellulosic, polymeric and resin materials with a certain permeability to air, which is used to prevent dust from entering the internal combustion process.The purpose of this research was to study and make air filter paper, based on which 4 samples of automobile air filter paper were produced. Samples with a combination of 2 types of cellulose fibers, imported short Kraft fibers and long Bangladeshi Kenaf fibers (skin) and one type of polymer fibers, Polyester fibers with a type of self-networking water-based Acrylic resin with glass conversion temperature (Tg) About 33 degrees Celsius and in the range of 20% by weight with a mass of about 120 g/m2 were...
hysical and Chemical Surface Modification of Titanium by Nanostructured Materials, and Biological Characterization for Use in Bone Tissue Implants
, Ph.D. Dissertation Sharif University of Technology ; Bagheri, Reza (Supervisor) ; Vossoughi, Manochehr (Supervisor) ; Samadi Kuchaksaraei, Ali (Supervisor)
Abstract
According to human needs and in line with the development of advanced technologies, different biomedical Engineering fields like hard tissue implants are growing rapidly. Despite significant biotechnology Developments in recent years, some problems to the recognition of implants related osseointegration phenomena persist. The deficient osseointegration and implant-associated infections are key issues for the long-term clinical success of titanium and titanium alloy implants, while development of multifunctional surfaces that can simultaneously overcome these problems remains highly challenging. Therefore, the ultimate goal of this paper was to improve bone cell attachment and simultaneously...
Bioinspired TiO2/chitosan/HA coatings on Ti surfaces: Biomedical improvement by intermediate hierarchical films
, Article Biomedical Materials (Bristol) ; Volume 17, Issue 3 , 2022 ; 17486041 (ISSN) ; Ahmadi Seyedkhani, S ; Eslami Saed, A ; Sadrnezhaad, S. K ; Seza, A ; Sharif University of Technology
Institute of Physics
2022
Abstract
The most common reasons for hard-tissue implant failure are structural loosening and prosthetic infections. Hence, in this study, to overcome the first problem, different bioinspired coatings, including dual acid-etched, anodic TiO2 nanotubes array, anodic hierarchical titanium oxide (HO), micro- and nanostructured hydroxyapatite (HA) layers, and HA/chitosan (HA/CS) nanocomposite, were applied to the titanium alloy surfaces. X-ray diffraction and FTIR analysis demonstrated that the in situ HA/CS nanocomposite formed successfully. The MTT assay showed that all samples had excellent cell viability, with cell proliferation rates ranging from 120% to 150% after 10 days. The HO coating...
Synthesis and Evaluation of A Catalyst for Selective Oxidation of H2S to Elemental Sulfur as A Desulfurization Method for Gaseous Streams
, M.Sc. Thesis Sharif University of Technology ; Hamzehlouyan, Tayebeh (Supervisor) ; Rashidi, Alimorad (Supervisor) ; Zamani, Yahya (Supervisor)
Abstract
The selective oxidation of H2S into elemental sulfur is a complementary desulfurization method for reducing H2S emissions from gas streams. Several studies have been conducted in recent years to develop active, selective, and stable catalysts. The purpose of this research is to develop a catalyst with high activity and selectivity that is suitable for the gas output of one of the country's refineries. For this purpose, three supports of mixed metal oxide (solid solution), Ce-Al, Ce-Si, and Ce-Zr with a molar ratio of 1:2 (ceria: metal) were made by the co-precipitation method. In the following, three samples named 10V-CeAl, 10V-CeSi, and 10V-CeZr were prepared by impregnating 10% wt vanadium...
Manufacturing and Evaluation of Carbon Dioxide Hydrogenation Reaction Catalyst for Methanol Production
, M.Sc. Thesis Sharif University of Technology ; Fotovat, Farzam (Supervisor) ; Zamaniyan, Akbar (Supervisor) ; Zamani, Yahya (Co-Supervisor) ; Rashidzadeh, Mehdi (Co-Supervisor)
Abstract
The hydrogenation of carbon dioxide to methanol represents a promising route for the efficient use of an anthropogenic greenhouse gas, in which catalysts play a key role in carbon dioxide conversion and methanol selectivity. In this study, firstly, CuO-ZnO-Al2O3, CuO-ZnO-ZrO2, CuO-ZnO-ZrO2-Al2O3, CuO-ZnO-Al2O3-CeO2 and CuO-ZnO-ZrO2-CeO2 catalysts were made using co-precipitation method, then these catalysts were characterized by inductively coupled plasma optical emission spectrometry, specific surface area and pore size distribution, X-ray diffraction, Field Emission Scanning Electron Microscopy, temperature programmed reduction. Finally, in order to compare the performance of the catalysts...
MiR-9-5p and miR-106a-5p dysregulated in CD4+ T-cells of multiple sclerosis patients and targeted essential factors of T helper17/regulatory T-cells differentiation
, Article Iranian Journal of Basic Medical Sciences ; Volume 21, Issue 3 , March , 2018 , Pages 277-283 ; 20083866 (ISSN) ; Hosseini, A ; Ghaedi, K ; Kiani Esfahani, A ; Tanhaei, S ; Shiralian Esfahani, H ; Rahnamaee, S. Y ; Mowla, S. J ; Nasr Esfahani, M. H ; Sharif University of Technology
Mashhad University of Medical Sciences
2018
Abstract
Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiation, the role of microRNAs in MS is not completely understood. Thereby, as a step closer, we analyzed the expression profile of miR-9-5p and miR-106a-5p, and protein level of retinoic acid receptor (RAR)-related orphan receptor C (RORC; Th17 master transcription factor) as direct target of miR-106a-5p...