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Bioinspired TiO2/chitosan/HA coatings on Ti surfaces: Biomedical improvement by intermediate hierarchical films

Rahnamaee, S. Y ; Sharif University of Technology | 2022

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  1. Type of Document: Article
  2. DOI: 10.1088/1748-605X/ac61fc
  3. Publisher: Institute of Physics , 2022
  4. Abstract:
  5. The most common reasons for hard-tissue implant failure are structural loosening and prosthetic infections. Hence, in this study, to overcome the first problem, different bioinspired coatings, including dual acid-etched, anodic TiO2 nanotubes array, anodic hierarchical titanium oxide (HO), micro- and nanostructured hydroxyapatite (HA) layers, and HA/chitosan (HA/CS) nanocomposite, were applied to the titanium alloy surfaces. X-ray diffraction and FTIR analysis demonstrated that the in situ HA/CS nanocomposite formed successfully. The MTT assay showed that all samples had excellent cell viability, with cell proliferation rates ranging from 120% to 150% after 10 days. The HO coating demonstrated superhydrophilicity (θ ≈ 0°) and increased the wettability of the metallic Ti surface by more than 120%. The friction coefficient of all fabricated surfaces was within the range of natural bone's mechanical behavior. The intermediate HO layer increased the adhesion strength of the HA/CS coating by more than 60%. The HO layer caused the mechanical stability of HA/CS during the 1000 m of friction test. The microhardness of HA/CS (22.5 HV) and micro-HA (25.5 HV) coatings was comparable to that of human bone. A mechanism for improved adhesion strength of HA/CS coatings by intermediate oxide layer was proposed. © 2022 IOP Publishing Ltd
  6. Keywords:
  7. Biomedical coating ; Surface modification ; Anodic oxidation ; Bond strength (materials) ; Bone ; Cell proliferation ; Coatings ; Friction ; Mechanical stability ; Metal implants ; Nanocomposites ; Sol-gels ; TiO2 nanoparticles ; Titanium alloys ; Titanium dioxide ; Anodic TiO2 ; Biomedical coatings ; Hard tissue implants ; Hydroxyapatite coating ; Implant failures ; Sol'gel ; Surface-modification ; Ti implant ; TiO2 nanotube arrays ; Titanium oxide layer ; Hydroxyapatite ; Nanocomposite ; Nanotube ; Oxide ; Titanium dioxide nanoparticle ; Biocompatible coated material ; Abrasion resistance ; Cell adhesion ; Cell viability ; Coating (procedure) ; Controlled study ; Fourier transform infrared spectroscopy ; Human ; Human cell ; Hydrophilicity ; Mechanics ; MG-63 cell line ; Microhardness ; MTT assay ; Sol-gel ; Wettability ; X ray diffraction ; Chemistry ; Surface property ; Chitosan ; Coated Materials, Biocompatible ; Durapatite ; Humans ; Surface Properties ; Titanium ; X-Ray Diffraction
  8. Source: Biomedical Materials (Bristol) ; Volume 17, Issue 3 , 2022 ; 17486041 (ISSN)
  9. URL: https://iopscience.iop.org/article/10.1088/1748-605X/ac61fc/meta