Environmental Monitoring of Formaldehyde in Biologics Production Areas Using Solid-Phase Microextraction Coupled to Gas Chromatography Mass Spectrometry

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Allahdad Lalouni, Misagh | 2009

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 39816 (03)
University: Sharif University of Technology
Department: Chemistry
Advisor(s): Bagheri, Habib; Eshaghi, Ali
Abstract:
During the recent years, manufactures and industries have paid attention to occupational health and safety of their employees. Formaldehyde is known as a probable carcinogenic agent and its large consumption made industries to consider it as a risk factor for occupational health. At vaccine production industries, Formaldehyde is used as disinfectant and stabilizer. In this study, a solid-phase microextraction (SPME) method based on kinetic and equilibrium calibration strategies was developed for monitoring of formaldehyde in the biologics production areas. The application and feasibility of three different sol-gel based SPME fibers with different polarities have been investigated. Two derivatizing agents, 2-benzylamino ethanol and o-(2,3,4,5,6-pentaflourobenzyl) hydroxylamine, were studied for in-situ derivization of formaldehyde. A detection limit of 46 ppbv and RSD of 5.7% at 670 ppbv were obtained for kinetic calibration. For equilibrium calibration these parameters were 23 ppbv and 5.4%, respectively.
Keywords:
Formaldehyde ; Solid Phase Microextraction ; Sol-Gel Method ; Gas Chromatography/Mass Spectrometry (GC/MS) ; Air Monitoring

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