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سنتز B- آمینوکربونیل ها در شرایط بدون حلال در حضور SiCl4 و ستنز مشتقات بنزوتیازول در آب
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سنتز B- آمینوکربونیل ها در شرایط بدون حلال در حضور SiCl4 و ستنز مشتقات بنزوتیازول در آب

باغی، رویا Baghi, Roya

Synthesis of β- Amino Carbonyl Compounds in Solvent-free Condition in the Presence of SiCl4 And Synthesis of Benzothiazole Derivatives

Baghi, Roya | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 40436 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Mahmoodi Hashemi, Mohammad; Azizi, Najmeddin
  7. Abstract:
  8. SiCl4 catalyzed Michael addition reaction of aliphatic and aromatic amines with different α,β- unsaturated compounds and one-pot three component Mannich reaction under solvent-free condition were investigated. β-amino carbonyl compound were synthesized in high yield in short reaction time. Furthermore, in the Mannich reaction good yield and excellent stereoselectivity were observed. In addition, the synthesis of 2-substituted benzothiazoles from aromatic aldehydes and 2 aminothiophenol in moderate to excellent yields in water in the presence of PTSA catalyst (10 mol%). This method provides a simple and efficient protocol in terms of mild reaction conditions, clean reaction profiles, small quantity of catalyst, and simple workup procedure.

  9. Keywords:
  10. Benzothiazole ; Michael Addition ; Michael Reaction ; B-Aminocarbonyls ; Aminothiophenol

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