Synthesis of Amines, Quinoxalines  and New 1,4-Dihydropyridines in Water, Reactions of Indoles and Oxidation of 1,4-Dihydropyridines Using Sodium Nitrite

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Ghafuri, Hossein | 2009

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Type of Document: Ph.D. Dissertation
Language: Farsi
Document No: 40826 (03)
University: Sharif University of Technology
Department: chemistry
Advisor(s): Mahmoodi Hashemi, Mohammad
Abstract:
Briefly in this thesis, these subjects have been investigated: In recent years, water is used as a solvent instead of an organic solvents have become more and more important due to cheap and environmental consideration. In this context, preparation of quinoxaline, pyrrole, new 1,4-dihydropyridine and reduction of imine to amine with 1,4-dihydropyridine derivatives as the reducing agents with the use of one-pot multicomponent reaction have been reported. The existence of several hydrogen bonding groups (NH) in the new dihydropyridines they acts as biologically active compounds in the forthcoming years. In continuation, oxidation of thiols to disulfides in the presence of NBS and NCS and preparation of bis(indolyl)methane and Michael type addition of indole with chalcone using of TMSCl as simple organocatalyst have been investigated. Furthermore, acidic clay catalyzed protection of alcohols and phenols with hexamethyldisilazane (HMDS) and oxidation of 1,4-dihydropyridine is presented.
Keywords:
Water ; Hexamethyldisilazane ; N-Bromosuccinimide ; 1,4-Dihydropyridine ; Organocatalyst ; Acidic Clay ; TrimethylSilylchloride

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