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Synthesis and Biocompatibility Evaluation of TiO2/Pyrolytic Carbon Core/Shell

Behzadi, Shahed | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41292 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Simchi, Abdolreza; Imani, Mohammad
  7. Abstract:
  8. Carbon-based thin films possess low friction coefficient, low surface roughness, chemical inertness and outstanding biocompatibility. In the present work, TiO2 nanoparticles were covered by a thin film of pyrolytic carbon (PyC) to provide a core-shell morphology. The PyC film was deposited by dehydrogenation of methane in a fluidized bed chemical vapour deposition (FBCVD) reactor at 1100 °C. The prepared specimens were characterized by various analytical methods including XRD, SEM, TEM, AFM, TGA and contact angle measurement techniques. Biocompatibility profiles of the resulting materials were evaluated using MTT and cell cycle assay. The results showed that the thin carbon film strongly suppresses the sintering and of titania nanoparticles at the high temperature. This phenomenon became more pronounced at higher precursor concentrations. It was also observed that PyC’s texture was influenced by the precursor concentration due to changes in tortuosity of the graphene layers. PyC films and the core-shell nanoparticles exhibited excellent biocompatibility in MTT assay. Apoptosis was also not observed during cell cycle assay. Better biocompatibility was obtained when the precursor gas concentration was increased
  9. Keywords:
  10. Core ; Shells ; Biocompatibility ; Core-Shell Nanostructure ; Titania ; Nanoparticles ; Chemical Vapor Deposition (CVD) ; Pyrolytic Carbon (PYC)

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