Investigation of phase Solubility Enhancement of Paclitaxel by Inclusion Complex of drug in B-CD-g-PG

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Jandaghi, Morteza | 2012

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 43514 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Yaghmaei, Soheyla; Vossoughi, Manoochehr; Kazemi Daliri, Akhtarolmoluk
Abstract:
Paclitaxel is using as a drug against breast and ovary cancers. Although paclitaxel has high biologic activity, it has very poor solubility in water the same as some other drugs. Since drugs should be solved in water to be absorbed by the body, for absorb enhancement, we should use carriers which includes both polar and non polar sites.
Beta-Cyclodextrin which has this feature is capable for producing inclusion complex in its hydrophobic pores with non polar materials. In this project, by adding polymeric polyglycerol branches on Beta-Cyclodextrin, a polymeric nanostructure has been developed to enhance water solubility in comparison with pure Beta-Cyclodextrin.
Study on producing polymeric “nanostructure – paclitaxel” inclusion complex and investigating solublity enhancement of paclitaxel by complexation using advanced experimental analyses such as NMR, HPLC, etc. have been the purpose of this survey.
By employing synthesized nanostructure paclitaxel solubility has increased 500 times. Hence, it can be concluded that this polymeric nanostructure has great potential to be used in drug delivery systems.
Keywords:
Nanostructure ; Pacli Taxel (PTX) ; Inclusion Complex ; Solubility ; Beta-Cyclodextrin

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