Design and Fabrication of Nanocamposite Scaffold for Neural Tissue Engineering

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Ramezani Farani, Marzieh | 2014

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 45546 (56)
University: Sharif University of Technology, International Campus, Kish Island
Department: Science and Engineering
Advisor(s): Ramazani Saadat Abadi , Ahmad; Neamati, ZiaratAli
Abstract:
Nervous system plays an intricate biological process of man body.Damage of nervous system has serious consequences and is hard to recover, as well as the other parts of the body may not work properly. Many strategies have been used to repair spinal cord injuries in which the main objective is to improve the regeneration of axons and functional recovery. The purpose of this research is introducing neural tissue engineering concepts (e.g. scaffolds, stimulation and etc.) and also design and fabrication suitable for neural tissue engineering. For this purpose the combination of biodegradable polymers (chitosan),conductive polymer (poly-aniline) and carbon nanosheets (graphene) was chosen as the base material for scaffold. This combination was chosen to have biocompatibility, proper mechanical properties and also high electrical conduct simultaneously. It is known that electrical conductivity is an important factor for repairing of nerve damages.
Keywords:
Chitosan ; Tissue Engineering ; Neuron ; Conductive Polymer ; Polyaniline ; Nanocomposite Scaffold

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