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Loading of Drug and Nanostructured Coating on Dental Implant

Abbaspour Ghomi, Somayya | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: English
  3. Document No: 46695 (57)
  4. University: Sharif University of Technology, International Campus, Kish Island
  5. Department: Science and Engineering
  6. Advisor(s): Sadrnezhaad, Khatiboleslam
  7. Abstract:
  8. The aim of this project is to load analgesic drug; Paracetamol on dental implant. The implant is titanium alloy (Ti-6Al-4V). There are two kinds of samples of anodized and HA coated onto anodized. They are in the shape of the sheets in this study. The electrodeposition and anodization carried out in order to treat the two samples. Nanotubes were formed during anodic oxidation of the samples in the 1M Ammonium sulfate (NH₄)₂SO4 and 5wt% Ammonium fluoride NH4F electrolyte. They are expected to play role of carrier for the model drug; paracetamol. The results showed that HA anodized Ti-6-4 has the ability to hold higher amounts of drug and also can keep the drug for a longer time than the anodized sample. Accordingly, the drug loading time for the anodized Ti alloy should be around 30 minutes but for the HA anodized it can continue to 45 minutes. Drug release behavior of the drug loaded samples was also tried to be determined by immersing the drug loaded samples into the release media; PBS (Phosphate Buffered Saline). XRD analysis proved the formation of HA on HA anodized sheet and a strong reflection at about 25.5 ° was observed. SEM micrograph revealed the formation of the nanotube arrays on the substrates. Mechanical properties were also evaluated by TriboScope system. The hardness and the elastic modulus of the samples were calculated by this examination and the anodized sample with 0.39 GPa showed higher hardness than HA anodized one with 0.12 GPa. Biocompatibility tests carried out using MTT assay in order to find the viability of different kinds of treated samples and also alizarin red staining was applied to observe the osteogenesis
  9. Keywords:
  10. Drugs ; Dental Implant ; Titanium Alloy ; Hydroxyapatite ; Nanocarrier ; Nanostructured Coating ; Release Mechanism

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