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Simulation of the Blood Flow in a Stenotic Left Coronary Bifurcation to Study the Effects on the Endothelial Cells

Jahromi, Reza | 2016

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48023 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Saeedi, Mohammad Saeed
  7. Abstract:
  8. Morphology and alignment of endothelial cells (ECs) have great influence on plaque formation. These alignments are based on the cyclic strains and wall shear stress (WSS) on the arterial wall. In the present study, cyclic strains and WSS are investigated to predict the secondary plaque locations downstream of the primary stenosis. Therefore, left coronary artery (LCA) with its branches to left anterior descending (LAD) and left circumflex (LCX) are 3D located on a virtual sphere to consider the cardiac motion. Stenoses are placed at the beginning of the bifurcation with varying degrees from 40% to 70% based on diameter reduction. Healthy coronary is also constructed to compare with those of atherosclerotic. The blood flow and the arterial wall are solved during a heart cycle using fluid-structure interaction (FSI) model. Moreover, the compliance of artery and vessel curvature variations due to cardiac motion are considered. Results show that the myocardial side of the arterial wall is more prone for new plaque formation than the epicardial side. In addition, it is concluded that primary stenosis length progression is more probable than secondary new plaque formation in the downstream of the primary stenosis
  9. Keywords:
  10. Fluid-Solid Interaction ; PLUGGING ; Strain ; Wall Shear Stress (WSS) ; Endothelial Cell ; Hemodynamics ; Coronary Artery

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