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Chitosan based supramolecular polypseudorotaxane as a pH-responsive polymer and their hybridization with mesoporous silica-coated magnetic graphene oxide for triggered anticancer drug delivery

Pourjavadi, A ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1016/j.polymer.2015.08.050
  3. Publisher: Elsevier Ltd , 2015
  4. Abstract:
  5. Chitosan based polyseudorotaxane was designed as a pH-responsive supramolecular polymeric shell around the mesoporous silica-coated magnetic graphene oxide (Fe3O4@GO@mSiO2). It was used for doxorubicin delivery at cancerous tissue in a controlled manner. The core-shell nanocarrier was formed due to electrostatic interaction between chitosan and carboxylated surface of Fe3O4@GO@mSiO2. The maximum release occurred at pH 5.5 (pH of endosomes) because the shell collapsed at this pH. The drug nanocarrier has potential application in tumor therapy due to good pH-sensitive behavior, improved solubility and high colloidal stability in biological media
  6. Keywords:
  7. Magnetic graphene oxide ; Chitin ; Chitosan ; Magnetism ; Mesoporous materials ; Polymers ; Silica ; Supramolecular chemistry ; Doxorubicin ; Graphene oxides ; Mesoporous Silica ; PH-responsive ; Polypseudorotaxanes ; Graphene
  8. Source: Polymer (United Kingdom) ; Volume 76 , October , 2015 , Pages 52-61 ; 00323861 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0032386115301890