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PEG-co-polyvinyl pyridine coated magnetic mesoporous silica nanoparticles for pH-responsive controlled release of doxorubicin

Pourjavadi, A ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1080/00914037.2014.996706
  3. Publisher: Taylor and Francis Inc , 2015
  4. Abstract:
  5. In the present work a pH responsive drug nanocarrier based on magnetic mesoporous silica nanoparticles (MMSN) and polyethylene glycol-co-polyvinyl pyridine (PEG-co-PVP) was prepared. The core-shell nanocarrier was formed due to electrostatic interaction between protonated polyvinyl pyridine and surface modified MMSN with carboxylate groups. This carrier was used for pH-controllable doxorubicin release. The maximum release was occurred at pH 5.5 (pH of endosomes). This carrier was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, UV-Vis spectrophotometer, scanning electron microscope, and high-resolution transmission electron microscope techniques. Also the zeta potential value and dynamic light scattering were measured. All characterizations confirmed the core-shell structure of the drug nanocarrier
  6. Keywords:
  7. Magnetic mesoporous silica nano particles ; Nanocarrier ; PEGylated polyvinyl pyridine ; Carboxylation ; Fourier transform infrared spectroscopy ; Light scattering ; Mesoporous materials ; Nanoparticles ; Polyethylenes ; Pyridine ; Scanning electron microscopy ; Silica ; Thermogravimetric analysis ; Doxorubicin ; Magnetic mesoporous silicas ; Nanocarriers ; Pegylated ; PH-responsive ; Nanomagnetics
  8. Source: International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 64, Issue 11 , 2015 , Pages 570-577 ; 00914037 (ISSN)
  9. URL: http://www.tandfonline.com/doi/full/10.1080/00914037.2014.996706