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The effects of reaction conditions on block copolymerization of chitosan and poly(ethylene glycol)

Ganji, F ; Sharif University of Technology | 2010

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  1. Type of Document: Article
  2. DOI: 10.1016/j.carbpol.2010.03.049
  3. Publisher: 2010
  4. Abstract:
  5. A novel injectable in situ gelling thermosensitive chitosan-block-poly(ethylene glycol) formulation was synthesized for drug delivery applications. Block copolymerization of monomethoxy-poly(ethylene glycol) onto chitosan using potassium persulfate as an initiator was carried under a nitrogen atmosphere in aqueous solution. The effects of potassium persulfate and poly(ethylene glycol) concentrations, reaction time and reaction temperature on block polymerization were studied by determining the yield of reaction (%Y), polymerization efficiency (%E) and add-on percentage (%Add-on). Keeping the other conditions constant, the optimum reaction conditions were found to be initiator = 0.01 M, reaction temperature = 60 °C and reaction time = 6 h
  6. Keywords:
  7. Aqueous solutions ; Block copolymerization ; Block polymerization ; Drug delivery applications ; In-situ-gelling ; Nitrogen atmospheres ; Optimum reaction conditions ; PEG ; Potassium persulfate ; Reaction conditions ; Reaction parameters ; Reaction temperature ; Reaction time ; Thermo sensitive ; Block copolymers ; Chitin ; Chitosan ; Copolymerization ; Drug delivery ; Ethylene ; Ethylene glycol ; Polyethylene oxides ; Potassium ; Polyethylene glycols
  8. Source: Carbohydrate Polymers ; Volume 81, Issue 4 , July , 2010 , Pages 799-804 ; 01448617 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S0144861710002298