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Inhibitory activity on type 2 diabetes and hypertension key-enzymes, and antioxidant capacity of veronica persica phenolic-rich extracts

Sharifi Rad, M ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.14715/cmb/2016.62.6.15
  3. Publisher: Cellular and Molecular Biology Association , 2016
  4. Abstract:
  5. Veronica genus (Plantaginaceae) is broadly distributed in different habitats. In this study, the inhibitory activity of free soluble and conjugated phenolic extracts of Veronica persica on key enzymes associated to type 2 diabetes (α-glucosidase and α-amylase) and hypertension (angiotensin I converting enzyme, ACE) was assessed, as well as their antioxidant power. Our results showed that both the extracts inhibited α-amylase, α-glucosidase and ACE in a dose-dependent manner. In particular, free phenolic extract significantly (P < 0.05) inhibited α-glucosidase (IC50 532.97 μg/mL), whereas conjugated phenolic extract significantly (P < 0.05) inhibited a-amylase (IC50 489.73 μg/mL) and ACE (290.06 μg/mL). The enzyme inhibitory activities of the extracts were not associated with their phenolic content. Anyway, the inhibition of α-amylase, α-glucosidase and ACE, along with the antioxidant capacity of the phenolic-rich extracts, could represent a putative mechanism through which V. persica exerts its antidiabetes and antihypertension effects
  6. Keywords:
  7. Angiotension I converting enzyme ; Ethnopharmacology ; Plantaginaceae ; Traditional medicine ; A-amylase ; A-glucosidase ; Alpha glucosidase ; Amylase ; Antioxidant ; Dipeptidyl carboxypeptidase inhibitor ; Enzyme inhibitor ; Glycosidase inhibitor ; phenol derivative ; Plant extract ; Antagonists and inhibitors ; Chemistry ; Enzymology ; Human ; Hypertension ; IC50 ; Metabolism ; Alpha-Amylases ; Alpha-Glucosidases ; Angiotensin-Converting Enzyme Inhibitors ; Antioxidants ; Diabetes Mellitus, Type 2 ; Enzyme Inhibitors ; Glycoside Hydrolase Inhibitors ; Humans ; Hypertension ; Inhibitory Concentration 50 ; Phenols ; Plant Extracts ; Veronica
  8. Source: Cellular and Molecular Biology ; Volume 62, Issue 6 , 2016 , Pages 80-85 ; 01455680 (ISSN)
  9. URL: https://www.ncbi.nlm.nih.gov/pubmed/27262808