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Comparing Effects of Natural Antibiotics and Anti Bacterial Materials in Burn Wound Infections with Nanoparticles and Skin Scaffold

Ramezani, Bita | 2018

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 50734 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Alemzadeh, Iran; Vosoughi, Manouchehr
  7. Abstract:
  8. Burns are one of the most important accidents related to human health. Due to the intense physical and mental complications and high fatality rate associated with them, receiving proper treatment is of paramount importance. The control of infection in wounds would cure and eliminates the effect of wounds and treatment of skin lesions with engineered scaffolds can be an effective method. The purpose of this project is proposing a hydrogel scaffold based on natural polymers of oxidized alginate and gelatin loaded with an herbal drug to control infection and treat burn wounds. For this purpose, the Iranian Oak extract that it's main content is Tanin and PolyPhenolinc materials, was prepared and by means of AgNO¬¬ and green synthesis formed as nanoparticles with average diameter 50±0.83 nm. Initially the effectiveness of this herbal medicine against S.areus and E.coli was compared with the common antibiotics such as gentamicin and cephalexin and due to its high effectiveness, an optimal scaffold from antibacterial, biological mechanical, and appropriate release of drug standpoints was fabricated. These scaffolds were fabricated without cross-linkers. The result demonstrated that Scaffolds would help cell migration due to their fibrous structure. Moreover, the data showed the suitable mechanical properties (Elastic moduli 0.25 Mpa and Elongation 280%) and degradability (30 days)
  9. Keywords:
  10. Tissue Engineering ; Silver Nanoparticles ; Hydrogel Scaffold ; Drug Delivery ; Alginate ; Antibacterials ; Natural Antibacterials

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