Bromo-lithium Exchange Reaction in Organic Synthesis and Continuous Separation of Organic and Aqueous phase Reactions by Microfloid Technique

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Pourasghar Mohammadi, Ali | 2017

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 50957 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Mohammadi, Ali Asghar; Bastani, Dariush
Abstract:
Today, with the development of micro-technology in chemical reactions, the use of appropriate systems for the separation and purification of synthesized chemicals seems to be necessary. In this study, the continuous synthesis of bromide-lithium exchange reaction and the separation of organic and aqueous phase products in micro systems was investigated.The method used to construct micro-separator and micro reactor, a laser engraving technique, and thermal bonding of glass to glass.In the first step, the factors affecting the separation of organic and aqueous phase in the capillary micro-separator, such as the width of the capillary, the length of the capillary, the number of capillaries and pressure drop in the main channel and the flow rate of phases were studied.After the design of the capillary separator by connecting a glass micro reactor to capillary separator, the exchange reaction of bromide-lithium in a continuous micro system was performed.The results showed that for the separation two equations Δp_sep<Δp_mc and Δp_mc-Δp_sep
Keywords:
Microreactor ; Bromine-Lithium Exchange Reaction ; Glass Microreactor ; Thermal Fusion Bonding ; Capillary Continuing ; Microfluidic System

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