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Proposing a Control Strategy for Treatment of Hepatitis C Disease

Ameli, Mahyar | 2018

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51459 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Shahrokhi, Mohammad
  7. Abstract:
  8. Due to the importance of hepatitis disease, especially hepatitis C, from public health view point, this research aims to investigate and suggest an efficient medical therapy for this disease. First, available models are analyzed and the suitable one is chosen. Three controllers namely, fixed PI, adaptive PI and exact linearization control (GLC) are designed to control the hepatitis C disease using the drug efficacy as the manipulated variabel. Controller parameters are determined by the Genetic Algorithm (GA) and their performances are evaluated using the selected model. Uncertainties have been considerd in both model structure and parameters and controllers performances are investigated in the presence of these types of model mismatch. Simulation results indicate that the adaptive PI and GLC have better performaces compared to the fixed PI. It should be noted that the adaptive PI in contrast to GLC needs only the measured output. Considering the fact that efficacy is dictated by the drug pharmacokinetics and pharmacodynamics, the related equations are used for development of the proposed treatment strategy. The drug dose which has an impulsive nature is considered as the manipulated variable. For this case, an adaptive PI controller is designed and the medical treatment regimen is proposed based on the drug dose. The performance of the proposed treatment has been tested for the selected and perturbed model. Simulation results indicate that the proposed drug regimen is suitable
  9. Keywords:
  10. Hepatitis C Virus ; Proportional-Integral-Derivative (PID)Controller ; Interferon ; Impulsive Linearizing Controller ; Exact Input-Output Linearization Control

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