Loading...

Experimental Study of Using Cellulosic Compounds in Tissue Engineering

Golizadeh, Mortaza | 2018

1025 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52177 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Vossoughi, Manouchehr; Karimi, Afzal; Faghihi, Faezeh
  7. Abstract:
  8. Fabrication and characterization of different surface charged cellulose electrospun scaffolds including cellulose acetate, cellulose, carboxymethyl cellulose and quaternary ammonium cationic cellulose for biomedical applications have been reported in this research. We describe preparation of cellulosic nanofibers through the electrospinning following deacetylation cellulose acetate. Moreover, surface modification of electrospun cellulose nanofibers is carried out to obtain carboxymethyl cellulose and quaternized cellulose nanofibers, respectively. At last, the structural, morphological, mechanical, swelling, wettability and the cell culture properties of the scaffolds were analyzed and compared. Fabricated cellulose acetate, cellulose, carboxymethyl cellulose and quaternary ammonium cationic cellulose nanofibers had 100-600 nm diameter, -9, -1.75, -12.8, +22 mV surface potential, 2.5, 4.2, 7.2, 7 MPa tensile strength, 122, 320, 515, 482 MPa Young modules, 430, 530, 670 and 642% water uptake and 92o, 58o, 45o, 47o contact angle respectively. The findings showed that cell adhesion and proliferation is strongly enhanced on the modified surfaces with quaternary ammonium and carboxymethyl groups. We believe the use of cationic and anionic surface modified cellulose electrospun nanofibers presents promising materials for biomedical applications
  9. Keywords:
  10. Cellulose ; Nanofiber ; Scaffold ; Functional Group ; Cell Culture Medium ; Tissue Engineering

 Digital Object List

 Bookmark

No TOC