Loading...

A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport

Fidan Yardimci, M ; Sharif University of Technology | 2019

1429 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.foodchem.2019.04.086
  3. Publisher: Elsevier Ltd , 2019
  4. Abstract:
  5. The bioavailability of drugs can be improved by regulating the structural properties, particularly lipoid systems, such as niosomes, can increase cellular uptake. Herein, we optimized double emulsion and niosomal formulations for encapsulating anthocyanin-rich black carrot extract. Nanoparticles obtained by selected formulation were characterized in terms of morphology, particle size, drug encapsulation efficiency, in vitro release and cytotoxicity. The optimum conditions for niosomal formulation were elicited as 30 mg of cholesterol, 150 mg of Tween 20 and feeding time of 1 min at a stirring rate of 900 rpm yielding the lowest average particle size of 130 nm. In vitro release data showed the majority of the encapsulated anthocyanins were released at the end of 10 h. A mathematical model was developed to estimate the absorption of anthocyanins released from niosomes and cytotoxicity was assessed against neuroblastoma. Overall, these findings suggest that niosomal vesicles might be suitable delivery systems for anthocyanins. © 2019 Elsevier Ltd
  6. Keywords:
  7. Anthocyanin ; Double emulsion ; In vitro release profile ; Neuro 2A ; Niosome ; Biochemistry ; Controlled drug delivery ; Emulsification ; Average particle size ; Delivery systems ; Double emulsions ; Drug encapsulation efficiency ; In-vitro ; Optimum conditions ; Targeted drug delivery ; Black carrot extract ; Plant extract ; Polysorbate 20 ; Unclassified drug ; Liposome ; Nanoparticle ; Polysorbate ; Article ; Carrot ; Cell proliferation ; Cell viability ; Controlled study ; Dispersity ; Drug absorption ; Drug cytotoxicity ; Drug formulation ; Drug release ; Emulsion ; Encapsulation ; Evaporation ; Glass transition temperature ; Human ; Human cell ; In vitro study ; Intestine absorption ; Mathematical model ; Michaelis constant ; Neuroblastoma ; Single drug dose ; Differential scanning calorimetry ; Drug effect ; Metabolism ; Theoretical model ; Tumor cell line ; Anthocyanins ; Calorimetry, Differential Scanning ; Cell Line, Tumor ; Cell Survival ; Cholesterol ; Daucus carota ; Humans ; Liposomes ; Models, Theoretical ; Nanoparticles ; Particle Size ; Polysorbates
  8. Source: Food Chemistry ; Volume 293 , 2019 , Pages 57-65 ; 03088146 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0308814619307502