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Production of Biocellulose Nanofibers by Gluconacetobacter and Evaluation of the Release of the Azithromycin Antibiotic Loaded on It in a Simulated Gastric Fluid

Gholizadeh, Yousef | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54195 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Alemzadeh, Iran
  7. Abstract:
  8. Bacterial cellulose is a kind of cellulose with high purity and Crystallization, which is mainly produced by gram-negative bacteria in aqueous media containing a sugar source.Cellulose produced by this method is in the form of nanofibers and one of its considerable aspects, nowadays, is that this kind of cellulose is used as a drug carrier system for treating various diseases. Azithromycin is used as an antibiotic for the treatment of a wide range of bacterial infections. In this study, cellulose nanofibers were synthesized by gluconacetobacter and its surface was modified using 0.5, 1, and 1.5 mg/ml carboxymethylcellulose solution in sodium acetate buffer. Then, by stabilizing azithromycin in the nanocellulose fiber network and considering cellulose nanoparticles as a drug carrier, the release of the drug in a gastric simulator was investigated. The results showed that low concentrations of carboxymethylcellulose produced nanofibers with a more porous structure, lower density, and more spongy texture. Therefore, the amount of the drug, loaded on its structure was higher and the release of the drug occurred faster. XRD analysis showed that the pattern of the produced nanofibers is polymorphic, V-shaped, and has a typical type II crystal structure. FTIR analysis indicates the presence of several OH groups in the structure of cellulose nanofibers. In addition to the OH group, C-OH, C-O-O, and C-H bonds are relatively abundant in the structure of nanocellulose
  9. Keywords:
  10. Drug Delivery ; Carboxymethyl Cellulose ; Bacterial Cellulose ; Biosynthetic Modulator ; Azithromycin

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