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Design and Optimization of Digital Microfluidic Chip for Cell Sorting

Orouji, Nooshin | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54321 (05)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Fardmanesh, Mehdi
  7. Abstract:
  8. Today, microfluidics, representing the precise and controlled displacement of small amounts of fluid, is one of the most efficient tools available in various research fields, including medicine. Digital microfluidics is one of the newest microfluidic methods, which is based on the theory of electrowetting on dielectric. According to this theory, by applying a voltage difference to a droplet of fluid on a hydrophobic surface, the droplet can be moved on that surface. Therefore, by fabricating a plate containing a number of electrodes completely isolated from each other and controlling them, small droplets of fluid can be moved on a hydrophobic surface. In this thesis, the electrodes of this chip are fabricated and tested by three methods: printed circuit boards, laser and silver paste, and lithography. On the other hand, the method of fabricating the electrodes with the help of laser and silver paste is a creative and novel method that is presented for the first time in this thesis. In the following, 6 types of dielectric materials and 4 types of hydrophobic materials for the dielectric and hydrophobic layers of the digital microfluidic chip, respectively, have been studied and tested. An electrical circuit has also been implemented to control and generate high voltage to connect to the electrodes. Finally, a schematic of a system for using the chip for medical and cellular purposes is presented, which makes this chip suitable and optimal for the use of cell sorting
  9. Keywords:
  10. Digital Microfluidics ; Electrowetting ; Dielectric Properties ; Cell Separation ; Cell Sorting ; Microfluidic Chip ; Biological Cells

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