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Simulation and Evaluation of Dosimetric Parameters of 125I Thermobrachytherapy Source with Ferromagnetic Core

Soleymanpoor, Mohammad | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54525 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Hosseini, Abolfazl; Sheibani, Shahab; Poorbaygi, Hossein; Mohagheghpour, Elham
  7. Abstract:
  8. In the method treatment of thermobrachytherapy, the method of this project, simultaneously use of two processes of thermotherapy and brachytherapy is considered, which can be a more effective treatment for the destruction of tumor tissue. In thermotherapy, the temperature of the tissue is artificially raised to a temperature that leads to cell dysfunction resulting in cell death. In brachytherapy, the destruction of defective tissue is done by placing a source in the tissue. In the present project, we supposed to consider both mechanisms simultaneously for treatment at the same time. In this project, radioactive material 125I is used as a source of radiation emission for brachytherapy. In the heat treatment system, ferromagnetic materials with nickel-copper alloy (70.4% nickel and 29.6% copper) is applyed in the construction of the source core, which is considers in generate heat. When the ferromagnetic material is exposed to an external magnetic field, it generates heat by aligning the magnetic moments with the external magnetic field. The process of increasing the temperature continues to Curie temperature. Due to the fact that the core temperature of the ferromagnetic core used in the present project is 42-48 °C, the tissue temperature rises to the mentioned temperature. In this project, initially, to ensure accuracy of simulation, the dosimetry parameters of thermobrachytherapy with a length of 5 mm and a diameter of 0.8 mm were calculated by simulation with MCNP code and compared with the results of the reference article. Then, the core of thermobrachytherapy is prepared by EBT3 radiochromic film became dosimetry and the experimental dosimetry system was simulated by MCNP Monte Carlo code and the results were compared. To validate the simulation calculations, a good match was obtained between the simulation and experimental results. Also, Figures 4-6 and 4-7, which is shown the curves of the radial dose function and the anisotropy function, respectively, there is good agreement between the trend of changes of these two parameters for thermobrackytherapy source and brachytherapy source model 2301 BEST seed. The differences at curves are also due to the material, physical appearance and different dimensions of the core in these two source
  9. Keywords:
  10. Brachytherapy ; Hyperthermia ; Monte Carlo N-Particle (MCNP)Code ; Radiation Sources ; Iodine-125 ; Thermobrachytherapy ; Intratumor Radiotherapy

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