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Synthesis and Characterization of Transition Metal Complexes Supported on Carbon-Based Nanocomposites and Their Application as Gene and Drug Delivery Systems

Safarkhani, Moein | 2022

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 55573 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Bagherzadeh, Mojtaba
  7. Abstract:
  8. In this dissertation, an attempt has been made to optimize some smart nanocarriers and the controllable release of drug (doxorubicin) and genetic material (plasmid CRISPR). Regarding, some metal nanoparticles, metal-organic frameworks, transition metal complexes, graphene oxide, and functionalized carbon nanotubes have been synthesized and also characterized and their hybrids and nanocomposites have been prepared successfully. All the abovementioned nanomaterials were designed and synthesized due to achieve biodegradable, biocompatible, higher positive surface potential, lower cytotoxicity, better responsivity to stimulus, and greener compounds. Doxorubicin and plasmid CRISPR has been utilized as model drug and gene. The greener, lower cytotoxic, more potent structure with smaller size, higher zeta potential, and more stepwise release have been prepared thanks to the extract of natural compounds and their various functional groups. It is noticeable that in-vivo studies have been conducted to evaluate the utilizability of synthesized compounds before clinical trials. The conducted survey revealed that amination of the structure could lead to lower cytotoxicity, higher antibacterial activity (%50), and increasing zeta potential (more than 13 eV), and coating the structure with biotin-rich extract (egg white) leads to gene transfection efficiency (more than %29) and decreasing the cytotoxicity. on the other hand, utilizing the metal-organic framework not only decreased the cytotoxicity but also increased the loading efficiency of a drug (more than %48).
  9. Keywords:
  10. Inorganic-Organic Hybrid Materials ; Natural Extract ; Metal-Organic Framework ; Smart Nanocarriers ; Doxorubicin ; Plasmid ; Palladium Complexes ; Smart Drug Nanocarrier ; Smart Gene Nanocarrier ; Targeted Druy Delivery

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