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Fabrication of Solid State Tunable Micro Pores using the Thermoplastic Polymers

Kazemi, Mohammad Mohsen | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57783 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Taghipoor, Mojtaba
  7. Abstract:
  8. The resistive pulse sensing (RPS) method based on the Coulter principle is a powerful method for particle counting and sizing in electrolyte solutions. This method involves measuring a current pulse that is produced as a particle transits a small channel, or pore. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications. An increasing number of production methods have been reported to make apertures, which have been able to achieve below 1 nm by continuously reducing the aperture size from hundreds of nanometers at the beginning. In general, the smaller the diameter, the shorter the length, and the higher the mechanical stability of a nanopore, the better its performance. To produce the more sensitive and reliable devices required by industry, researchers have begun to explore possible methods for producing nanopores, which pose challenges in terms of manufacturing efficiency, accuracy and repeatability, applicable materials, time, and cost. In this research, thermoplastic polymers have been used as a membrane containing micro and nano pores. A novel method for fabricating nanopores has been developed by heating thermoplastic polymer and pressing two blades into this softened polymer. While this method is simple, low-cost and very fast, it has high accuracy, reproducibility and significant stability. It can be seen that the size of the pore can be controlled and changed with three design variables: time, temperature and intrusion. Also, by choosing different polymers, we are looking for the best option for making pores in nanometer dimensions. The results obtained from the particle test were analyzed and finally, using the resistive pulse sensing test and the common methods of counting and measuring, we obtained the properties and characteristics of the particles. The measurement of DNA particles is a very important step in the resistance pulse sensing method. So finally, by using pores made on polyethylene terephthalate polymer (PET), whose dimensions reach about 10 nm, we sense DNA particles. It has been observed that this research and the fabricated nanopores are capable of detecting particles with a diameter of 2 nanometers
  9. Keywords:
  10. Resistive Pulse Sensing ; Micropore Fabrication ; Temperature ; Microfluidic System ; Aerosol Measurement ; DNA Sequencing ; Time ; Intrusion ; Thermoplastic Polymers

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