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Design and Synthesis of a Drug Delivery System Based on Mesoporous Bioactive Glass

Mirsafaie, Sahar Sadat | 2024

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 57917 (06)
  4. University: Sharif University of Technology
  5. Department: Electrical Engineering
  6. Advisor(s): Abdekhodaie, Mohammad Jafar
  7. Abstract:
  8. The aim of this research is to develop a smart mesoporous bioactive glass-based carrier for targeted drug delivery to cancer cells, particularly bone cancer cells. To achieve this, mesoporous bioactive glass nanoparticles were first synthesized, followed by surface modification with amine groups. To prevent premature drug release before reaching the target tissue and to introduce pH sensitivity, the nanoparticle pores were coated with oxidized hyaluronic acid via Schiff-base bonding with the amine groups on the surface. The use of hyaluronic acid facilitates active targeting of CD44 receptors, which are overexpressed on the surface of cancer cells compared to healthy cells. This process ultimately leads to the endocytosis of the carrier into cancer cells. To evaluate the release behavior of this carrier, metformin was used as a model drug. SEM analysis confirmed that the nanoparticles exhibited a spherical morphology with an average diameter of 77 nm. The mesoporous structure was verified through BET analysis, which revealed a pore diameter of 2.41 nm and a specific surface area of 629 m²/g. Additionally, the bioactivity of these nanoparticles was demonstrated using SEM, EDS, and XRD analyses. The accuracy of the synthesis and functionalization was confirmed by FT-IR and NMR spectroscopy. Finally, drug release studies indicated that amine-functionalized nanoparticles exhibited more controlled drug release compared to unmodified nanoparticles. A comparison of the drug release profile from oxidized hyaluronic acid-coated nanoparticles at pH 7.4 (simulating physiological pH) and pH 6.5 (simulating the tumor microenvironment) showed that drug release was higher at pH 6.5 than at physiological pH. These findings suggest that the oxidized hyaluronic acid-coated carrier can regulate drug release in physiological conditions while enabling enhanced drug release in the tumor environment, which may improve drug efficacy
  9. Keywords:
  10. Mesoporous Materials ; Bioactive Glass ; Targeted Druy Delivery ; Cancer ; Stimuli-Sensitive ; Hyaluronic Acid Gel ; Effect of pH on Release ; Drug Release

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