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Deformation characterization of mouse oocyte cell using inverse finite element and LevenbergâMarquardt optimization algorithm in needle injection experiment

Abbasi, A. A ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1115/DETC2012-70025
  3. Publisher: 2012
  4. Abstract:
  5. In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanicalproperties of mouse oocyte cell. It has been assumed that the cell behavior is continues, isotropic, nonlinear and homogenous material. Then, by matching the experimental data with finite element (FE) simulation result and using the LevenbergâMarquardt optimization algorithm, the nonlinear hyperelastic model parameters have been extracted. Experimental data of mouse oocyte captured from literatures. Advantage of the developed model is that it can be used to calculate accurate reaction force on surgical instrument or it can be used to compute deformation or force in virtual reality based medical simulations
  6. Keywords:
  7. Finite element simulations ; Hyperelastic models ; Inverse finite elements ; Medical simulations ; Needle injection experiments ; Neo-Hookean material ; Optimization algorithms ; Surgical instrument ; Algorithms ; Biomechanics ; Design ; Finite element method ; Mammals ; Mechanical properties ; Surgical equipment ; Virtual reality ; Deformation
  8. Source: Proceedings of the ASME Design Engineering Technical Conference, 12 August 2012 through 12 August 2012 ; Volume 2, Issue PARTS A AND B , August , 2012 , Pages 847-852 ; 9780791845011 (ISBN)
  9. URL: http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1736184