Loading...

Photo-destruction of cancer cells by NIR irradiation and graphene nano-sheets

Abdolahad, M ; Sharif University of Technology | 2011

1219 Viewed
  1. Type of Document: Article
  2. Publisher: 2011
  3. Abstract:
  4. The photo-thermal therapy using nano-materials has attracted great attention as an efficient strategy for the next generation of cancer treatments. Recently, photo-thermal therapy based on nano-materials that can be activated by a skin-penetrating NIR (Near Infra Red) irradiation has been suggested as a noninvasive, harmless, and highly efficient therapeutic technique. Graphene nano-layers synthesized by a bio-compatible method, with reduced toxicity, will be a suitable candidate for the photo-thermal therapeutic agent. A significant amount of heat is generated upon excitation with near-infrared light (NIR, 700-1100nm) which is transparent to biological species including skins. In this paper, we demonstrate destruction of solid malignant cells (colon cancer cells) by the combined treatments of biocompatible graphene nano-layers and NIR irradiation. MTT methods show that more than 85% of the cells which held with autoclaved graphene solution remained alive after 24hr. In addition, NIR laser exposure with a 250 mw diode laser (780 nm) to colon cancer cells (without graphene inclusion) for 15 min kills less than 9% of colon cancer cells but exposing the NIR beam to the graphene-added cells for 25 min kills more than 66% of the cells
  5. Keywords:
  6. Bio compatible ; Biological species ; Cancer cell ; Cancer cells ; Colon cancer cells ; Combined treatment ; Efficient strategy ; Laser exposure ; Malignant cells ; MTT method ; Nano layers ; Near Infrared ; Near infrared light ; Near-IR ; Photo destruction ; Photo-thermal ; Reduced toxicity ; Therapeutic agents ; Therapeutic techniques ; Diseases ; Fluidics ; Graphene ; Infrared devices ; Irradiation ; Medical nanotechnology ; MEMS ; Nanosensors ; Cells
  7. Source: Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, 13 June 2011 through 16 June 2011, Boston, MA ; Volume 3 , 2011 , Pages 236-239 ; 9781439871386 (ISBN)