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    The burden of unintentional drowning: Global, regional and national estimates of mortality from the Global Burden of Disease 2017 Study

    , Article Injury Prevention ; 2020 Franklin, R.C ; Peden, A.E ; Hamilton, E.B ; Bisignano, C ; Castle, C.D ; Dingels, Z.V ; Hay, S.I ; Liu, Z ; Mokdad, A.H ; Roberts, N.L.S ; Sylte, D.O ; Vos, T ; Abady, G.G ; Abosetugn, A.E ; Ahmed, R ; Alahdab, F ; Andrei, C.L ; Antonio, C.A.T ; Arabloo, J ; Kinfe Arba, A.A ; Badiye, A.D ; Bakkannavar, S.M ; Banach, M ; Banik, P.C ; Banstola, A ; Barker-Collo, S.L ; Barzegar, A ; Bayati, M ; Bhardwaj, P ; Bhaumik, S ; Bhutta, Z.A ; Bijani, A ; Boloor, A ; Carvalho, F ; Kabir Chowdhury, M.A ; Chu, D.-T ; Colquhoun, S.M ; Dagne, H ; Dagnew, B ; Dandona, L ; Dandona, R ; Daryani, A ; Dharmaratne, S.D ; Dibaji Forooshani, Z.S ; Do, H.T ; Driscoll, T.R ; Eagan, A.W ; El-Khatib, Z ; Fernandes, E ; Filip, I ; Fischer, F ; Gebremichael, B ; Gupta, G ; Haagsma, J.A ; Hassan, S ; Hendrie, D ; Hoang, C.L ; Hole, M.K ; Holla, R ; Hostiuc, S ; Househ, M ; Ilesanmi, O.S ; Inbaraj, L.R ; Naghibi Irvani, S.S ; MofzulIslam, M ; Ivers, R.Q ; Jayatilleke, A.U ; Joukar, F ; Kalhor, R ; Kanchan, T ; Kapoor, N ; Kasaeian, A ; Khan, M ; Khan, E.A ; Khubchandani, J ; Krishan, K ; Anil Kumar, G ; Lauriola, P ; Lopez, A.D ; Madadin, M ; Majdan, M ; Maled, V ; Manaf, N ; Manaf, A ; McKee, M ; Meles, H.G ; Menezes, R.G ; Meretoja, T.J ; Miller, T.R ; Mithra, P ; Mohammadian-Hafshejani, A ; Mohammadpourhodki, R ; Mohebi, F ; Molokhia, M ; Mustafa, G ; Negoi, I ; Nguyen, C.T ; Thi Nguyen, H.L ; Olagunju, A.T ; Olagunju, T.O ; Padubidri, J.R ; Pakshir, K ; Pathak, A ; Polinder, S ; Angga Pribadi, D.R ; Rabiee, N ; Radfar, A ; Rana, S.M ; Rickard, J ; Safari, S ; Salamati, P ; Samy, A.M ; Sarker, A.R ; Schwebel, D.C ; Senthilkumaran, S ; Shaahmadi, F ; Shaikh, M.A ; Shin, J.I ; Singh, P.K ; Soheili, A ; Stokes, M.A ; Rasul Suleria, H.A ; Tarigan, I.U ; Temsah, M.-H ; Tesfay, B.E ; Valdez, P.R ; Veisani, Y ; Ye, P ; Yonemoto, N ; Yu, C ; Yusefzadeh, H ; Zaman, S.B ; Zhang, Z.-J ; James, S.L ; Sharif University of Technology
    BMJ Publishing Group  2020
    Abstract
    Background: Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive causes of injury-related mortality in the Global Burden of Disease (GBD) study. This study's objective is to describe unintentional drowning using GBD estimates from 1990 to 2017. Methods: Unintentional drowning from GBD 2017 was estimated for cause-specific mortality and years of life lost (YLLs), age, sex, country, region, Socio-demographic Index (SDI) quintile, and trends from 1990 to 2017. GBD 2017 used standard GBD methods for estimating mortality... 

    A Metabonomics Study of Samples of Different Diseases: Investigation of Linear and Non-Linear Model by Nuclear Magnetic Resonance

    , Ph.D. Dissertation Sharif University of Technology Fathi, Fariba (Author) ; Tafazzoli, Mohsen (Supervisor)
    Abstract
    Metabonomics is a quantitative measurement of time dependent metabolic interactions for living systems in response to the pathological or genetic variations. NMR spectroscopy has emerged as a key tool for understanding metabolic processes in living systems. In this project, the study of metabolomics was performed as classification and regression on samples of parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease. In classification part, various methods were applied using optimal parameters.classification methods in Parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease were RF, CART, PLS-DA, RF and RF respectively. Based on the... 

    Skin diseases modeling using combined tissue engineering and microfluidic technologies

    , Article Advanced Healthcare Materials ; Volume 5, Issue 19 , 2016 , Pages 2459-2480 ; 21922640 (ISSN) Mohammadi, M. H ; Heidary Araghi, B ; Beydaghi, V ; Geraili, A ; Moradi, F ; Jafari, P ; Janmaleki, M ; Valente, K. P ; Akbari, M ; Sanati Nezhad, A ; Sharif University of Technology
    Wiley-VCH Verlag 
    Abstract
    In recent years, both tissue engineering and microfluidics have significantly contributed in engineering of in vitro skin substitutes to test the penetration of chemicals or to replace damaged skins. Organ-on-chip platforms have been recently inspired by the integration of microfluidics and biomaterials in order to develop physiologically relevant disease models. However, the application of organ-on-chip on the development of skin disease models is still limited and needs to be further developed. The impact of tissue engineering, biomaterials and microfluidic platforms on the development of skin grafts and biomimetic in vitro skin models is reviewed. The integration of tissue engineering and... 

    Global trends of hand and wrist trauma: A systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study

    , Article Injury Prevention ; 2020 Crowe, C. S ; Massenburg, B.B ; Morrison, S.D ; Chang, J ; Friedrich, J.B ; Abady, G.G ; Alahdab, F ; Alipour, V ; Arabloo, J ; Asaad, M ; Banach, M ; Bijani, A ; Borzì, A.M ; Briko, N.I ; Castle, C.D ; Cho, D.Y ; Chung, M.T ; Daryani, A ; Demoz, G.T ; Dingels, Z.V ; Do, H.T ; Fischer, F ; Fox, J.T ; Fukumoto, T ; Gebre, A.K ; Gebremichael, B ; Haagsma, J.A ; Haj-Mirzaian, A ; Handiso, D.W ; Hay, S.I ; Hoang, C.L ; Irvani, S.S.N ; Jozwiak, J.J ; Kalhor, R ; Kasaeian, A ; Khader, Y.S ; Khalilov, R ; Khan, E.A ; Khundkar, R ; Kisa, S ; Kisa, A ; Liu, Z ; Majdan, M ; Manafi, N ; Manafi, A ; Manda, A.-L ; Meretoja, T.J ; Miller, T.R ; Mohammadian Hafshejani, A ; Mohammadpourhodki, R ; Mohseni Bandpei, M.A ; Mokdad, A.H ; Naimzada, M.D ; Ndwandwe, D.E ; Nguyen, C.T ; Nguyen, H.L.T ; Olagunju, A.T ; Olagunju, T.O ; Pham, H.Q ; Pribadi, D.R.A ; Rabiee, N ; Ramezanzadeh, K ; Ranganathan, K ; Roberts, N.L.S ; Roever, L ; Safari, S ; Samy, A.M ; Sanchez Riera, L ; Shahabi, S ; Smarandache, C.-G ; Sylte, D.O ; Tesfay, B.E ; Tran, B.X ; Ullah, I ; Vahedi, P ; Vahedian Azimi, A ; Vos, T ; Woldeyes, D. H ; Wondmieneh, A. B ; Zhang, Z. J ; James, S. L ; Sharif University of Technology
    BMJ Publishing Group  2020
    Abstract
    Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period. Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations. Results: The global incidence of hand trauma has only modestly... 

    Sensing of alzheimer's disease and multiple sclerosis using nano-bio interfaces

    , Article Journal of Alzheimer's Disease ; Volume 59, Issue 4 , 2017 , Pages 1187-1202 ; 13872877 (ISSN) Hajipour, M. J ; Ghasemi, F ; Aghaverdi, H ; Raoufi, M ; Linnef, U ; Atyabi, F ; Nabipour, I ; Azhdarzadeh, M ; Derakhshankhah, H ; Lotfabadi, A ; Bargahi, A ; Alekhamis, Z ; Aghaie, A ; Hashemi, E ; Tafakhori, A ; Aghamollaii, V ; Mashhadi, M. M ; Sheibani, S ; Vali, H ; Mahmoudi, M ; Sharif University of Technology
    Abstract
    It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP... 

    A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

    , Article DARU, Journal of Pharmaceutical Sciences ; 2018 ; 15608115 (ISSN) Davatgaran Taghipour, Y ; Bahramsoltani, R ; Marques, A. M ; Naseri, R ; Rahimi, R ; Haratipour, P ; Panah, A. I ; Farzaei, M. H ; Abdollahi, M ; Sharif University of Technology
    Abstract
    Inflammatory bowel diseases (IBD), which is classified into Crohn’s disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article. This approach may potentially overcome some complications that are associated with conventional means of colon... 

    Disorders of the musculoskeletal system among Tehran, Iranian dentists

    , Article Journal of Musculoskeletal Pain ; Vol. 22, issue. 3 , 2014 , pp. 256-259 ; ISSN: 10582452 Shadmehr, A ; Haddad, O ; Azarnia, S ; Sanamlo, Z ; Sharif University of Technology
    Abstract
    Objectives: Although dental practitioners are confronted with a number of musculoskeletal disorders, relatively few studies have focused on this profession. The aim of this study was to investigate the prevalence of some musculoskeletal complaints of dentists in Iran. Methods: Four hundred and forty-six dentists in Tehran city, Iran were surveyed to determine the prevalence of musculoskeletal problems. We administrated a Persian-language version of the Nordic Questionnaire for this purpose. Results: Data gathered from Iranian dentists showed that most dentists [81%] reported pain in at least one joint. The most prevalent musculoskeletal disorders during the previous 12 months were reported... 

    Global analysis of an SAIS model

    , Article Journal of Biological Dynamics ; Volume 6, Issue 2 , 2012 , Pages 457-474 ; 17513758 (ISSN) Razvan, M. R ; Yasaman, S ; Sharif University of Technology
    2012
    Abstract
    This paper is concerned with global analysis of an SAIS epidemiological model in a population of varying size introduced by Busenberg and van den Driessche. In this model the population is divided into three subgroups of susceptible, asymptomatic and infective individuals. It has been shown that this system has no periodic solutions and all its trajectories tend to the equilibria of the system. We use the Poincaré Index theorem to determine the number of the equilibria and their stability properties. We have shown that bistability occurs for suitable values of parameters and found a set of examples of all possible dynamics of the system  

    Higher prevalence of asymptomatic or mild COVID-19 in children, claims and clues

    , Article Journal of Medical Virology ; Volume 92, Issue 11 , May , 2020 , Pages 2257-2259 Miri, S. M ; Noorbakhsh, F ; Mohebbi, S. R ; Ghaemi, A
    John Wiley and Sons Inc  2020

    A Quantitative Structure-Activity Relationship Study on Multiple Sclerosis (MS) Drugs

    , M.Sc. Thesis Sharif University of Technology Torkashvand, Rezvan (Author) ; Jalali-Heravi, Mehdi (Supervisor)
    Abstract
    In the present work we report a quantitative structure-activity relationship (QSAR) study on S1P1 receptor’s agonists that have therapeutic potential for autoimmune disorders such as Multiple Sclerosis (MS). Such studies play an important role in drug design and lead optimization by developing a mathematical relationship between the chemical structures of compounds and their biological activities.
    We used both linear and nonlinear techniques such as MLR and ANN respectively to model these compounds together with techniques such as Stepwise-MLR, GA-MLR and GA-ANN in the variable selection step as it is an important step in every QSAR study. Since topological descriptors are well... 

    Measuring viscoelastic properties of Red Blood Cell using optical tweezers

    , Article Iranian Journal of Physics Research ; Volume 19, Issue 1 , 2019 , Pages 101-108 ; 16826957 (ISSN) Seyed Reihani, S. N ; Azadbakht, A ; Mirzahossein, E ; Mottaghian, M ; Babaei, M ; Sharif University of Technology
    Isfahan University of Technology  2019
    Abstract
    Efforts have been made to study the behavior of complex materials in micrometer dimensions with various techniques. One of these methods is the use of optical tweezers for biophysical applications. Red blood cells, as the most abundant blood-forming cells, play an important role in the life of living organisms, and their unique mechanical properties are important. In this report, the study of soft materials is done using light tweezers. This work investigates micrometer particle movements in the optical trap and also, when they are connected to a red blood cell. The tweezers allow the Newtonian fluid viscosity, such as water and glycerin, to measure the mechanical properties of viscoelastic... 

    Measuring viscoelastic properties of Red Blood Cell using optical tweezers

    , Article Iranian Journal of Physics Research ; Volume 19, Issue 1 , 2019 , Pages 101-108 ; 16826957 (ISSN) Seyed Reihani, S. N ; Azadbakht, A ; Mirzahossein, E ; Mottaghian, M ; Babaei, M ; Sharif University of Technology
    Isfahan University of Technology  2019
    Abstract
    Efforts have been made to study the behavior of complex materials in micrometer dimensions with various techniques. One of these methods is the use of optical tweezers for biophysical applications. Red blood cells, as the most abundant blood-forming cells, play an important role in the life of living organisms, and their unique mechanical properties are important. In this report, the study of soft materials is done using light tweezers. This work investigates micrometer particle movements in the optical trap and also, when they are connected to a red blood cell. The tweezers allow the Newtonian fluid viscosity, such as water and glycerin, to measure the mechanical properties of viscoelastic... 

    Identifying brain functional connectivity alterations during different stages of alzheimer’s disease

    , Article International Journal of Neuroscience ; 2020 Ahmadi, H ; Fatemizadeh, E ; Motie-Nasrabadi, A ; Sharif University of Technology
    Taylor and Francis Ltd  2020
    Abstract
    Purpose: Alzheimer's disease (AD) starts years before its signs and symptoms including the dementia become apparent. Diagnosis of the AD in the early stages is important to reduce the speed of brain decline. Aim of the study: Identifying the alterations in the functional connectivity of the brain during the disease stages is among the main important issues in this regard. Therefore, in this study, the changes in the functional connectivity during the AD stages were analyzed. Materials and methods: By employing the functional magnetic resonance imaging (fMRI) data and graph theory, weighted undirected graphs of the whole-brain and default mode network (DMN) network were investigated... 

    Interplay between competitive and cooperative interactions in a three-player pathogen system

    , Article Royal Society Open Science ; Volume 7, Issue 1 , 2020 Pinotti, F ; Ghanbarnejad, F ; Hövel, P ; Poletto, C ; Sharif University of Technology
    Royal Society Publishing  2020
    Abstract
    In ecological systems, heterogeneous interactions between pathogens take place simultaneously. This occurs, for instance, when two pathogens cooperate, while at the same time, multiple strains of these pathogens co-circulate and compete. Notable examples include the cooperation of human immunodeficiency virus with antibiotic-resistant and susceptible strains of tuberculosis or some respiratory infections with Streptococcus pneumoniae strains. Models focusing on competition or cooperation separately fail to describe how these concurrent interactions shape the epidemiology of such diseases. We studied this problem considering two cooperating pathogens, where one pathogen is further structured... 

    Markovian approach to tackle the interaction of simultaneous diseases

    , Article Physical Review E ; Volume 100, Issue 6 , 2019 ; 24700045 (ISSN) Soriano Panos, D ; Ghanbarnejad, F ; Meloni, S ; Gomez Gardenes, J ; Sharif University of Technology
    American Physical Society  2019
    Abstract
    The simultaneous emergence of several abrupt disease outbreaks or the extinction of some serotypes of multistrain diseases are fingerprints of the interaction between pathogens spreading within the same population. Here, we propose a general and versatile benchmark to address the unfolding of both cooperative and competitive interacting diseases. We characterize the explosive transitions between the disease-free and the epidemic regimes arising from the cooperation between pathogens and show the critical degree of cooperation needed for the onset of such abrupt transitions. For the competing diseases, we characterize the mutually exclusive case and derive analytically the transition point... 

    Regeneration of stochastic processes: An inverse method

    , Article European Physical Journal B ; Volume 47, Issue 3 , 2005 , Pages 411-415 ; 14346028 (ISSN) Ghasemi, F ; Peinke, J ; Sahimi, M ; Rahimi Tabar, M. R ; Sharif University of Technology
    2005
    Abstract
    We propose a novel inverse method that utilizes a set of data to construct a simple equation that governs the stochastic process for which the data have been measured, hence enabling us to reconstruct the stochastic process. As an example, we analyze the stochasticity in the beat-to-beat fluctuations in the heart rates of healthy subjects as well as those with congestive heart failure. The inverse method provides a novel technique for distinguishing the two classes of subjects in terms of a drift and a diffusion coefficients which behave completely differently for the two classes of subjects, hence potentially providing a novel diagnostic tool for distinguishing healthy subjects from those... 

    An optimum design and simulation of an innovative mobile robotic nurse unit to assist paraplegic patients

    , Article Proceedings of the IEEE International Conference on Mechatronics 2004, ICM'04, Istanbul, 3 June 2004 through 5 June 2004 ; 2004 , Pages 141-147 ; 0780385993 (ISBN) Meghdari, A ; Hosseinkhannazer, H ; Selkghafari, A ; Sharif University of Technology
    2004
    Abstract
    This paper describes a nursing robot system currently under development at the Center of Excellence in Design, Robotics and Automation. Our goal was to design and fabricate of a robot specifically for paraplegic patients and the design procedure led to a plan which can be employed in any hospital environment. Through the design procedure, the team members conducted a survey on the robot client's needs and disabilities which provided a unique view on mechanical design features, in addition to, performing dynamical analysis on the designed mechanisms. Dynamical Simulation of mechanisms helped us to find the best design and solutions as well as optimization of parts has resulted in a matchless... 

    How do the smart travel ban policy and intercity travel pattern affect COVID-19 trends? Lessons learned from Iran

    , Article PLoS ONE ; Volume 17, Issue 10 October , 2022 ; 19326203 (ISSN) Nassiri, H ; Mohammadpour, S. I ; Dahaghin, M ; Sharif University of Technology
    Public Library of Science  2022
    Abstract
    COVID-19, as the most significant epidemic of the century, infected 467 million people and took the lives of more than 6 million individuals as of March 19, 2022. Due to the rapid transmission of the disease and the lack of definitive treatment, countries have employed non-pharmaceutical interventions. This study aimed to investigate the effectiveness of the smart travel ban policy, which has been implemented for non-commercial vehicles in the intercity highways of Iran since November 21, 2020. The other goal was to suggest efficient COVID-19 forecasting tools and to examine the association of intercity travel patterns and COVID-19 trends in Iran. To this end, weekly confirmed cases and... 

    Market of Kidney in Iran

    , M.Sc. Thesis Sharif University of Technology Didgar, Dadmehr (Author) ; Fatemi Ardestani, Farshad (Supervisor)
    Abstract
    In this study we developed an analytical model to delve into the behavior of participants in the market of kidney in Iran. We get health as a good which not only elevates the utility of any individual, it add more years to each individual longevity. We find out that ESRD patients who are in serious need of receiving a new kidney will never postpone buying kidney in case of having the price fixed in all periods.We found out that the waiting time in queue of receiving market is a u-shape function in which there is a minimum. We proved that the price making the queue minimum is definitely bigger than the market clearance market. Accordingly, despite all the unfair and immoral view toward... 

    Development of An Intelligent System For Thyroid Disease Diagnosis , Modeling And Simulation of Thyroid Hormone In Human Body

    , M.Sc. Thesis Sharif University of Technology Orouskhani, Erfan (Author) ; Bozorgmehri, Ramin (Supervisor)
    Abstract
    The abstract is the most important section of the thesis because many readers limit most of their reading to abstracts, saving in-depth reading for specific theses. It should give the reader a "preview" of what's to come. The abstract should emphasize new and important aspects of the study or observations. The purpose of the abstract is to allow researchers to decide whether or not to read the whole thesis. The abstract is what researchers read first to decide if the thesis is important, interesting, and it allows them to assess the relevance of a thesis to their own research, without having to read the entire thesis. Thus, it is crucial that the abstract both summarize succinctly the key...