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    Evaluation of Functional and Structural Networks of Healthy Macaque Monkey Brains and Comparison with Macaque Monkeys with Parkinson’s in Previous Research

    , M.Sc. Thesis Sharif University of Technology Yousef Abadi, Matin (Author) ; Rabiee, Hamid Reza (Supervisor)
    The brain is one of the most critical parts of the body with a lot of complexity. The treatment of brain diseases has always been in an aura of uncertainty due to its high sensitivity. In the meantime, Parkinson's disease has become the second most frequent brain disease after Alzheimer's, involving more than two percent of the population over 65 years of age. One of the biggest questions in this field is how the Parkinson's process is formed. This question has already received much attention from the pathophysiological point of view but has not been answered from the functional and structural brain network's point of view. This research compares healthy macaque monkeys' functional and... 

    Well-posedness of Two Mathematical Models for Alzheimer's Disease

    , M.Sc. Thesis Sharif University of Technology Yarmohammadi, Parisa (Author) ; Hesaaraki, Mahmoud (Supervisor)
    In season 1, we introduce a mathematical model of the in vivo progression of Alzheimer’s disease with focus on the role of prions in memory impairment. Our model consists of differential equations that describe the dynamic formation of Aβ -amyloid plaques based on the concentrations of Aβ oligomers, PrPC proteins, and the Aβ-×-PrPC complex, which are hypothesized to be responsible for synaptic tox- icity. We prove the well posedness of the model and provided stability results for its unique equilibrium, when the polymerization rate of β-amyloid is constant and also when it is described by a power law. In seson 2, We consider the existence and uniqueness of solutions of an initial-boundary... 

    Analysis of a Mathematical Model Describing the Geographical Spread of Dengue Disease

    , Ph.D. Dissertation Sharif University of Technology Gazori, Fereshteh (Author) ; Hesaaraki, Mahmoud (Supervisor)
    Dengue is one of the most important infectious diseases in the world. This disease is a viral infection that is transmitted to humans through the bite of a mosquito called Aedes aegypti. For this reason, geographical regions infected with this type of mosquito are at risk of Dengue outbreak. In this thesis, we first present a mathematical model describing the geographical spread of Dengue disease, which includes the movement of both the human population and the winged mosquito population. This model is derived from a mixed system of partial and ordinary differential equations. Our proposed model has the ability to consider the possibility of asymptomatic infection, so that the presence of... 

    Simulation, Design and fabrication of Kidney on a Chip

    , Ph.D. Dissertation Sharif University of Technology Kiyoumarsioskouei, Amir (Author) ; Saeedi, Mohammad Saeed (Supervisor) ; Firoozabadi, Bahar (Supervisor) ; Mosadegh, Bobak ($item.subfieldsMap.e)
    Renal diseases and consequently kidney failure is one of the important death factors around the world in recent years. It causes hundreds of thousands die every year and is in progress. Researchers believe that increasing chemical and nonchemical materials density in the blood which is the air pollution, use of tobacco and other parameters cause renal cells misfunction in urine filtration and regulation of blood pressure. The goal of this work is design and fabrication of a microfluidic device which provides different cell types to be cultured and imposed pressure. To do this, a high throughput microfluidic device is needed to mimic kidney biologically. Having such a device helps to analyze... 

    The Application of Profile Monitoring in Healthcare for Disease Monitoring- case Study

    , M.Sc. Thesis Sharif University of Technology Chabok, Sheyda (Author) ; Rafiee, Majid (Supervisor)
    Profile Monitoring is a new research topics in the field of statistical process control. In many applications of statistical quality control, sometimes quality of a process or product described by a relationship between a response variable and one or more independent variables.The researchers call this relationship profile. The study seeks to demonstrate that monitoring profiles In addition, the industry can be effective in medical field and improves control of the patient's condition by a doctor. Profiles are usually modeled with a linear regression equation, non-linear or polynomial. finally, the results of this study, using actual data, models and methods to predict and control... 

    Urine Analysis by a Microfluidic Paper-Based Device for Renal Function Test

    , M.Sc. Thesis Sharif University of Technology Pourghanbari Marvast, Mohadeseh (Author) ; Saadatmand, Maryam (Supervisor)
    Chronic kidney disease is one of the silent diseases that progresses slowly, often without symptoms, and can eventually lead to kidney loss. Early detection of this disease can help diagnose it and prevent further problems. Urinary creatinine is an effective biomarker for early diagnosis of chronic kidney disease, but methods available in clinics are problematic for people living in disadvantaged areas because of the high cost and the need for 24-hour urine collection. Currently, paper-based microfluidic devices are being developed because they are easy to manufacture, inexpensive, the fluid is permeable by capillary force, and no additional equipment is needed. In this work, to fabricate a... 

    Development of a Human Activity Recognition System with an Adaptive Neuro-Fuzzy Post-Processing for the Lee Silverman Voice Treatment-BIG and Functional Activities

    , M.Sc. Thesis Sharif University of Technology Partovi, Ehsan (Author) ; Behzadipour, Saeed (Supervisor)
    Human Activity Recognition (HAR) has had tremendous improvements in the field of elderly monitoring and telerehabilitation. An anchor point for HAR systems in telerehabilitation is supervising rehabilitative excercises. For Parkinson’s disease (PD) patients, a group of rehabilitative activities, known as Lee Silverman Voice Treatment-BIG, or LSVT-BIG, have shown to be effective in improving motor performance. Similar to any rehabilitative measure, delivering these activities requires the supervision of an expert or clinician, so that the patient receives proper feedbacks. HAR systems can replace human experts. They can recognize activities and provide the user with proper feedback. HAR... 

    A Mathematical Model to Organize Transplants in a Kidney Exchange Program with Uncertain Failures

    , M.Sc. Thesis Sharif University of Technology Porbar, Gohar (Author) ; Najafi, Mehdi (Supervisor) ; Shadrokh, Shahram (Supervisor)
    Kidney transplants are vital for patients with end-stage kidney disease. Therefore, it is essential to allocate kidneys to patients efficiently. Kidney Exchange Programs allow patients with incompatible donors to exchange donors and receive a suitable kidney. In practice, these exchanges occur within cyclic or chain-like structures. Planned transplants may be canceled before the transplant takes place, for a variety of reasons. Failure of one transplant in a cycle or chain can result in the failure of all transplants in that cycle or chain, which can lead to drastic inefficiency in the exchange program.In this thesis, we study kidney exchange programs under uncertainty. We consider... 

    Modeling the Relationship between Central Aortic Pressure and Radial Photoplethysmogram in Flow-mediated Dilation Test

    , Ph.D. Dissertation Sharif University of Technology Parsafar, Mohammad Habib (Author) ; Vosughi Vahdat, Bijan (Supervisor) ; Zahedi, Edmond (Supervisor)
    According to the World Health Organization, about 35% of deaths worldwide are due to cardiovascular diseases, therefore the evaluation of vascular endothelial function has great prognostic and diagnostic value for cardiovascular diseases. The conventional noninvasive method for endothelial function evaluation is the measurement of flow-mediated dilation in brachial artery using ultrasound imaging (FMD-US). As the accuracy of FMD-US depends on the operator's skill and the resolution of the ultrasound images, this method has not been adopted. In this work, we propose to use a low cost, easily-accessible surrogate signal, the photoplethysmogram (PPG) to implement the FMD test. Whereas previous... 

    Algorithms of Genome-Wide Association Studies

    , M.Sc. Thesis Sharif University of Technology Valishirin, Hossein (Author) ; Foroughmand Aarabi, Mohammad Hadi (Supervisor)
    The field of Genome-Wide Asocciation Studies (GWAS) plays a vital role in understanding the genetic basis of complex traits and diseases. In this thesis, the focus is on investigating the effectiveness of two approaches combining Differential Evolution (DE) with Random Forest (RF) and support vector machine (SVM) for feature selection in the context of GWAS. Arabidopsois Thaliana dataset is used as experimental dataset for comparative analysis. The main goal is to achieve more efficient feature selection while maintaining competitive accuracy compared to RF and SVM without using DE. This research includes conducting experiments using DE with RF and DE with SVM followed by a comprehensive... 

    Analyzing Dermatological Data for Disease Detection Using Interpretable Deep Learning

    , M.Sc. Thesis Sharif University of Technology Hashemi Golpaygani, Fatemeh Sadat (Author) ; Rabiee, Hamid Reza (Supervisor) ; Sharifi Zarchi, Ali (Supervisor) ; Ghandi, Narges (Co-Supervisor)
    We present a deep neural network to classify dermatological disease from patient images. Using self-supervised learning method we have utilized large amount of unlabeled data. We have pre-trained our model on 27000 dermoscopic images gathered from razi hospital, the best dermatological hospital in Iran, along with 33000 images from ISIC 2020 dataset. We have evaluated our model performance in semi-supervised and transfer learning approaches. Our experiments show that using this approach can improve model accuracy and PRC up to 20 percent on semi-supervised setting. The results also show that pretraining can improve classification PRC up to 20 percent on transfer learning task on HAM10000... 

    An Analysis of a Mathematical Model Describing the Geographic Spread of Dengue Disease

    , M.Sc. Thesis Sharif University of Technology Hashemifar, Alireza (Author) ; Hesaraki, Mahmoud (Supervisor)
    We consider a system of nonlinear partial differential equations corresponding to a generalization of a mathematical model for geographical spreading of dengue disease. the mosquito population is divided into subpopulations: winged form (mature female mosquitoes) and aquatic form (comprising eggs, larvae and pupae); the human population is divided into the subpopulations:susceptible, infected and removed (or immune). On the other hand we allow higher spatial dimensions and also parameters depending on space and time. is last generalization is done to cope with possible abiotic effects as variations in temperature, humidity, wind velocity, carrier capacities, and so on; thus, the results... 

    Diagnosis of COVID-19 Using Deep Learning Techniques

    , M.Sc. Thesis Sharif University of Technology Nourparvar, Azadeh (Author) ; Hemmatyar, Ali Mohammad Afshin (Supervisor)
    In the last few years, the most important problem to find a solution for the COVID-19 disease, and tests show that many factors are effective in the health and recovery of people with this disease. Therefore, scientists all over the world are looking to prevent the spread of this disease by identifying the effective factors in the recovery of corona patients and finding solutions for their health. The proposed algorithm is hybrid deep learning model CNN+GRU and appeal them to the laboratory test data from hospital. In this research, the goal is to be able to diagnose this disease in time with routine laboratory test, which consist of three main stages. In the first stage: initial... 

    Application Microarray Technology in Infectious Diseases

    , M.Sc. Thesis Sharif University of Technology Nazari Nodooshan, Khadijeh (Author) ; Mahdavi-Amiri, Nezameddin (Supervisor) ; Karami, Ali (Co-Advisor)
    DNA microarrays consist of DNA microscopic points that are attached to a solid surface such as glass, plastic or silicon chip and formed as an array. The fixed pieces of DNA are considered as searchers. In an experiment, we can use thousands of searchers. Therefore, any microarray consists of the same number of genetic tests as the experiment performed on all of them in parallel. Whit this ability, arrays have speeded up the biological investigations. Microarray technology can be seen as a continued development of southern blotting. However, the most important stage in this technology, analysis of data, requires reliable bioinformatics tools achieving high reliabilities. Infectious diseases,... 

    Design and Fabrication of Drug-loaded Nanoparticles to Prevent Fibrillation of Alpha-synuclein in Parkinson

    , M.Sc. Thesis Sharif University of Technology Nayebzadeh, Ramin (Author) ; Mashayekhan, Shohreh (Supervisor) ; Morshedi, Dina (Supervisor)
    The purpose of this study is to assess the inhibitory effects of an appropriate nanoparticles loaded with gallic acid on the fibrillation of alpha-synuclein. Alpha-synuclein is a major component of protein plaques in synucleinopathies, particularly Parkinson’s disease. Gallic acid (GA, 3,4,5-trihydroxy benzoic acid) is a well–known small molecule which can inhibit the formation of α-synuclein fibrils. For the process of fibrillation, purified protein was incubated at 37◦C and pH 7.2. Fibrillation was analyzed by the standard fibril methods.after that investigated fabricating of gallic acid trapped in the chitosan nanoparticles and gallic acid loaded in chitosan –coated mesoporous silica... 

    Modeling the Kidney Market in Iran

    , M.Sc. Thesis Sharif University of Technology Naderi Tabar, Mohammad (Author) ; Fatemi Ardestani, Farshad (Supervisor)
    The purpose of this study is to model people's behavior on both sides of the kidney market. The healthy person decides to donate a live kidney (for a certain amount) on the supply side. On the demand side, the patient chooses between the two existing kidney queues, the living kidney and the cadaveric kidney, based on the individual's income and belief from the waiting time in each of the two queues. The sick person faces two critical risks in life: risk of death and kidney failure. To model these two risks, it is assumed that each person has a level of health that consists of two deterministic and stochastic parts. In this way, with a deterministic rate, a person's health level will decrease... 

    Study and Comparison the Incidence of Dutch Disease in Iranian Economy in Two Periods of Oil Shock

    , M.Sc. Thesis Sharif University of Technology Momeni, Atefeh Sadat (Author) ; nili, Masoud (Supervisor) ; Madanizadeh, Ali (Supervisor)
    This paper studies and compares the effect of "Dutch disease" in Iranian economy in two periods of rising oil price (1973-1978) and (2004-2010). The study presents a DSGE model to analysis the behavior of economic variable in both periods and to address this question that whether or not policy maker has learning behavior. The model consists of households, final goods producers who divided in tradable goods and non-tradable goods sector and the government. I use calibration methods to estimate models parameters.Comparison of simulated results and the actual macroeconomic variables in Iran during 1338-1390 indicates that, first of all Dutch disease effect occur in both periods of oil shock so... 

    Modeling of Different Geometries of Children's Heart Occluder's by Finite Element Method

    , M.Sc. Thesis Sharif University of Technology Mousavizadeh, Mohammad Hossein (Author) ; Arghavani, Jamal (Supervisor)
    Congenital heart defects are a type of heart diseases that some babies get at birth. These diseases generally have symptoms such as shortness of breath, headache, impaired blood supply, hyperplasia of the lungs, enlarged heart, and so on. In the past, open heart surgery was commonly used to treat such diseases, which was a costly and risky procedure. But over time, occluders made it easier. An occluder is referd to a device that is generally minimally invasive in the area of the fault and could block it. The occluders are usually braided type, with inside polyethylene fibers, where tissues can grow and clogs the defect over time. Although occluders have greatly increased the success rate of... 

    Identifying and Predicting Tumor and MS Disease Through MRI Data of Patients by Data Mining Tools

    , M.Sc. Thesis Sharif University of Technology Moazeni, Mehran (Author) ; Akhavan Niaki, Taghi (Supervisor)
    Today with the development of technology in medical science, there is a need to develop new methods to analyze and process the medical images. Furthermore, increasing use of machines and computers to accomplish prediction goals delineates that these tools had promising results. Because of all the above, this research focuses on processing and analyzing medical images with using data mining tools in order to identify MS and tumor disease which have been ubiquitous in last decades, fast and meticulous. To do so, we introduce a new clustering algorithm based on the modularity measure of graph networks as well as a new machine learning algorithm based on Kalman filter for Tensor-based data.... 

    Simulation of the Influence of Hypertension on Low Density Lipoprotein (Ldl) Permeation into Multilayer Coronary Bifurcation

    , M.Sc. Thesis Sharif University of Technology Moniri Piri, Mohammad (Author) ; Firoozabadi, Bahar (Supervisor)
    Atherosclerosis, due to the penetration of low-density lipoprotein particles (LDL) into the arterial wall, is one of the most common and death-leading diseases in today's world. Due to its importance, extensive research has been conducted on the factors that affect this disease. In this thesis, a numerical study of the effects of Wall Shear Stress (WSS), non-Newtonian behavior of blood, different hematocrit values, and blood pressure on LDL permeation through the artery wall layers are investigated in a 4-layer wall model of a coronary bifurcation. To obtain the velocity and concentration fields in the domain, momentum, Brinkman, and mass transport equations are solved in the lumen and wall...