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    Expansion Modeling of Coronary Stent for Selection of Optimized Stent

    , M.Sc. Thesis Sharif University of Technology Izadi Ramini, Elaheh (Author) ; Movahhedy, Mohammad Reza (Supervisor)
    Referring to mortality increasment having sprung from atherosclerosis, work on treatment of coronary heart disease seems to be necessary. Stent implementation is one of stenosis treatment. Stent deployment has been done during past two decades, but clinical evidence showed that because of some weakness in designing and implementing, restenosis occurs again. Material, structure and coating texture of stent are the designing criteria beside stent implementation importance. Thus a lot of activities have been done in this area to improve performance of these applications. Nowadays a lot of companies' researchers try the best to get better their products; consequently there is different types of... 

    Application Microarray Technology in Infectious Diseases

    , M.Sc. Thesis Sharif University of Technology Nazari Nodooshan, Khadijeh (Author) ; Mahdavi-Amiri, Nezameddin (Supervisor) ; Karami, Ali (Co-Advisor)
    DNA microarrays consist of DNA microscopic points that are attached to a solid surface such as glass, plastic or silicon chip and formed as an array. The fixed pieces of DNA are considered as searchers. In an experiment, we can use thousands of searchers. Therefore, any microarray consists of the same number of genetic tests as the experiment performed on all of them in parallel. Whit this ability, arrays have speeded up the biological investigations. Microarray technology can be seen as a continued development of southern blotting. However, the most important stage in this technology, analysis of data, requires reliable bioinformatics tools achieving high reliabilities. Infectious diseases,... 

    Stimulus Signal Improvement in Order to Alleviate the Symptoms of Parkinson's Disease in Rat

    , M.Sc. Thesis Sharif University of Technology Gholipour, Saman (Author) ; Vosughi Vahdat, Bijan (Supervisor)
    Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra. The cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related. Some of the symptoms are: shaking, rigidity, slowness of movement and difficulty with walking and gait. Modern treatments are effective at managing the early motor symptoms of the disease, mainly through the use of levodopa and dopamine agonists. As the disease progresses these drugs eventually become ineffective and produce a complication called dyskinesia, marked by... 

    Early Detection of Cardiac Arrhythmia Based on Bayesian Methods from ECG Data

    , Ph.D. Dissertation Sharif University of Technology Montazeri Ghahjaverestan, Nasim (Author) ; Shamsollahi, Mohammad Bagher (Supervisor) ; Hernandez, Alfredo (Co-Advisor)
    Apnea Bradycardia (AB) episodes (breathing pauses associated with a significant fall in heart rate) are the most common disease in preterm infants. Consequences associated with apnea-bradycardia episodes involve a compromise in oxygenation and tissue perfusion, a poor neuromotor prognosis at childhood and a predisposing factor to sudden-death syndrome in preterm newborns. It is therefore important that these episodes are recognized (early detected or predicted if possible), to start an appropriate treatment and to prevent the associated risks. In this thesis, we propose two Bayesian Network (BN) approaches (Markovian and Switching Kalman Filter) for the early detection of apnea bradycardia... 

    The Application of Profile Monitoring in Healthcare for Disease Monitoring- case Study

    , M.Sc. Thesis Sharif University of Technology Chabok, Sheyda (Author) ; Rafiee, Majid (Supervisor)
    Profile Monitoring is a new research topics in the field of statistical process control. In many applications of statistical quality control, sometimes quality of a process or product described by a relationship between a response variable and one or more independent variables.The researchers call this relationship profile. The study seeks to demonstrate that monitoring profiles In addition, the industry can be effective in medical field and improves control of the patient's condition by a doctor. Profiles are usually modeled with a linear regression equation, non-linear or polynomial. finally, the results of this study, using actual data, models and methods to predict and control... 

    Air Pollution Effects on Mortality

    , M.Sc. Thesis Sharif University of Technology Moghani, Vahid (Author) ; Rahmati, Mohammad Hossein (Supervisor) ; Vesal, Mohammad (Supervisor)
    In this paper evaluate the short-term effects of air pollution on the mortality rate caused by cardiovascular problems, respiratory problems, digestive problems and tumors and cancers. This is done by using daily mortality data of Tehran, Tabriz, Mashad, Shiraz, Ahwaz and Isfahan during the years 1390 to 1394, we also use daily measurements of pollutant levels including Carbon-monooxcide, Sulfure-dioxide, Oxides of Nitrogen, Ozone and Particulate matters in the same period. The effects are estimad by looking at the relation of daily mortality in each city along with its pollution level. By controling for the weather conditions and city and month fixed effects, we find significant positive... 

    Development of a Fall Risk Assessment Method Based on COP Data in Parkinson’s Disease

    , M.Sc. Thesis Sharif University of Technology Shokouhi, Shabnam (Author) ; Behzadipour, Saeed (Supervisor)
    In recent years, there has been an increasing interest in posturography methods as an objective quantitative tool for assessing balance and indicating patient with high risk of fall. Although many posturographic studies tried to describe balance deficiencies in PD, little success has been achieved in utilizing static posturography as a tool for discriminating faller and non-faller PD patients. Furthermore, Dynamic posturography studies have delivered valuable insight into the potentiality of these methods for assessing balance, but these devices are very high in price and cumbersome to move that can limit the feasibility of their use in the clinical settings. The aims of this study were: 1)... 

    Design, Fabrication and Analyses of an Ultrasonic Probe for Kidney Lithotripsy Device

    , M.Sc. Thesis Sharif University of Technology Amini, Naseh (Author) ; Ahmadian, Mohammad Taghi (Supervisor) ; Firoozbakhsh, Keykhosrow (Supervisor)
    Kidney stone disease is one of the diseases that a large number of people experience each year.A Common method for the treatment of kidney stone is the use of acoustic waves, which have attracted the attention of doctors in recent decades. Because of the different structure of kidney stones, the waves transmitted to break these stones are usually performed at different frequencies. Most kidney stones are calcium that can be broken down by using acoustic wave frequencies in the range of 40-20 KHz. Most available lithotripters for the treatment of percutaneous nephrolithotomy (PCNL) are two types: Pneumatic and piezoelectric lithotripters. The lithotripter in this thesis is a piezoelectric... 

    Intelligent Diagnosis of Cardiovascular Disease using ECG Signals

    , M.Sc. Thesis Sharif University of Technology Baghdadi, Fatemeh (Author) ; Haj Sadeghi, Khosrow (Supervisor)
    Cardiovascular diseases (CVDs) have ranked first cause of deaths globally. In 2016, about 17.7 million people died from CVDs representing 31% of all world deaths. So, early intelligent detection of cardiovascular disease could help to save many lives in worldwide. There are several methods to analyze heart activity and to detect any abnormalities including Electrocardiogram, Stress test, Echocardiography, cardiac catheterization and coronary angiography.Among all methods, Electrocardiogram (ECG) is the most common and convenient type where it measures heart electrical activity and records it as a series of pulses. Analyzing these pulses would provide useful information about normal and... 

    Market of Kidney in Iran

    , M.Sc. Thesis Sharif University of Technology Didgar, Dadmehr (Author) ; Fatemi Ardestani, Farshad (Supervisor)
    In this study we developed an analytical model to delve into the behavior of participants in the market of kidney in Iran. We get health as a good which not only elevates the utility of any individual, it add more years to each individual longevity. We find out that ESRD patients who are in serious need of receiving a new kidney will never postpone buying kidney in case of having the price fixed in all periods.We found out that the waiting time in queue of receiving market is a u-shape function in which there is a minimum. We proved that the price making the queue minimum is definitely bigger than the market clearance market. Accordingly, despite all the unfair and immoral view toward... 

    Prediction Using Data Mining Techniques in Healthcare

    , M.Sc. Thesis Sharif University of Technology Aliyari, Fateme (Author) ; Akhavan Niaki, Taghi (Supervisor)
    Poor decision making in health care has always had irreparable consequences for society. Also, expensive medical tests cause lots of problems for patients. A huge amount of data is produced daily by hospitals, which unfortunately are not used to improve decision making and predicting disease. Data mining can be an appropriate tool for extracting knowledge from a huge amount of data by using a variety of techniques such as prediction. The leading cause of death in the world is heart disease so this study has been designed to predict the incidence of that. Regarding the literature review, the Naïve Bayes method had predicted heart disease accurately. According to the specialist's opinion, some... 

    Application of Data Mining Techniques in Diagnosis & Prediction of Heart Disease

    , M.Sc. Thesis Sharif University of Technology jahangiri, Sonia (Author) ; Akhavan Niaki, Taghi (Supervisor)
    Nowadays, data is the most important asset for health organizations in which the process of collecting, storing and analyzing of data leads to success of health organizations. Many companies have turned to data mining for the beneficial use of these data. The main purpose of data mining is to obtain useful knowledge from existing data. One of the diseases that is very significant for data miners is cardiovascular disease. Cardiovascular disease is the most important cause of death in the world. Therefore, it is necessary to improve the diagnostic and predictive measures of these patients. In this study, a database containing of characteristics of patients with chest pain who referred to... 

    Investigating the Effects of DBS on Brain Connectivity by Causal Inference in Parkinson’s Disease

    , M.Sc. Thesis Sharif University of Technology Ostad Mohammadi, Mohammad (Author) ; Rabiee, Hamid Reza (Supervisor)
    Parkinson’s disease (PD) is a progressive debilitating neurological disorder that causes motor and cognitive impairment. Administration of dopaminergic medication (Levodopa) has been reported to be effective in attenuating the excessive pathological synchronization in basal ganglia. However, long term levodopa therapy has its pitfalls. High frequency deep brain stimulation (DBS) has been suggested as an effective alternative for reducing motor symptoms in PD. In this method, distinct brain regions involved in the pathophysiology of the disease are stimulated electrically at high frequencies (i.e. at 130 Hz). While several studies have been carried out on the effects of DBS and its clinical... 

    An Approach to Optimize Resource Allocation and Strategies to Control Infectious Diseases

    , M.Sc. Thesis Sharif University of Technology Mohammadi, Ahmad (Author) ; Najafi, Mehdi (Supervisor)
    Infectious diseases have always been a threat to mankind, and is the greatest causes of death of children and young people. Although this type of diseases is a serious threat to public health; the allocated resources in responding to a semi-large pandemic is inadequate. Therefore, it is important to spend the resources in the most effective and efficient ways to improve pandemic response capability. That is why considerable research be devoted to study different aspects of epidemics, and developed mathematical approaches to choose appropriate strategies in pandemic response. Since the epidemic models are simplified means to describe the transmission of disease, researchers often use these... 

    Queue Modeling of Patients in Waiting list of Kidney Transplantation

    , M.Sc. Thesis Sharif University of Technology Amini, Fatemeh (Author) ; Modarres Yazdi, Mohammad (Supervisor)
    As the number of patients waiting for receiving kidney transplantation increases all over the world, the average waiting time for a patient in queue rises too, and consequently, the rate of death goes beyond the accepted level. Also, unbalanced numbers of donors and patients with same blood type make the problem bolder. The aim of this research is to design a queuing model in which kidney could be transplanted from deceased donors to patients with different but compatible blood type (Cross-Transplantation) in order to make the average waiting time for patients with different blood type closer to each other. In other words, the transplant system is supposed to make a decision whether to... 

    Design and Fabrication of Drug-loaded Nanoparticles to Prevent Fibrillation of Alpha-synuclein in Parkinson

    , M.Sc. Thesis Sharif University of Technology Nayebzadeh, Ramin (Author) ; Mashayekhan, Shohreh (Supervisor) ; Morshedi, Dina (Supervisor)
    The purpose of this study is to assess the inhibitory effects of an appropriate nanoparticles loaded with gallic acid on the fibrillation of alpha-synuclein. Alpha-synuclein is a major component of protein plaques in synucleinopathies, particularly Parkinson’s disease. Gallic acid (GA, 3,4,5-trihydroxy benzoic acid) is a well–known small molecule which can inhibit the formation of α-synuclein fibrils. For the process of fibrillation, purified protein was incubated at 37◦C and pH 7.2. Fibrillation was analyzed by the standard fibril methods.after that investigated fabricating of gallic acid trapped in the chitosan nanoparticles and gallic acid loaded in chitosan –coated mesoporous silica... 

    Biosensor for Fast Detection (Based on Thyroid Hormones)

    , M.Sc. Thesis Sharif University of Technology Moradi, Farshid (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    Thyroid gland is one of the important internal organs of the body that is responsible for T3 and T4 hormones secretion. Concentration of these hormones directly influences growth of body, thus measurement concentration of thyroid hormones is one of the most common experiments all of the world, specially in our country that Hypothyroidism is common among people. Secretion of hormones in thyroid gland controlled by TSH (thyroid Stimulating Hormone) that released from Pituitary gland. TSH concentration is opposite of level of thyroid secretion. Because of interconnected relationship between these three hormones, measurement of each of them is so important. Many researches for developing... 

    Rapamycin Loaded Chitosan Nanopartilces to Cure Coronary Artery Blockage: Synthetize And Characterization

    , M.Sc. Thesis Sharif University of Technology Manafi Rad, Arash (Author) ; Simchi, Abdolreza (Supervisor) ; Shokrgozar, Mohammad Ali (Supervisor)
    Coronary artery diseaseaffects millions of persons and isone of the leading causes of morbidity and mortality worldwide. Invasive techniques such as coronary artery bypassgrafting are used to alleviate the lesion of arterial occlusion.Unfortunately, restenosis or occlusion of the graftedconduit occurs over a time frame of months to years with a gradual reduction in patency, especially in vein grafts. Theevents leading to intimal hyperplasia (IH) formation involve numerous cellular and molecular components. Variouscellular elements of the vessel wall are involved as are leucocyte–endothelial interactions that trigger the coagulationcascade leading to localized thrombus formation. Subsequent... 

    Alzheimer's Disease Diagnosis Using Brain Source Localiztion, Based on Realistic Head Model

    , M.Sc. Thesis Sharif University of Technology Aghajani, Haleh (Author) ; Vosoughi Vahdat, Bijan (Supervisor) ; Jalili, Mahdi (Co-Advisor)
    Dementia is one of the most common disorders among the elderly population. Statistical analyses show that among several subtypes of dementia, Alzheimer’s disease (AD) is the most frequent cause of dementia and this number is projected to increase. AD not only results in impairment of learning and memory but also in the moderate stages of illness, motor functions are profoundly disturbed, and ultimately will affect the patient's lifetime. The proposed drug treatments for this disease only reduce its progress probability. Therefore, early diagnosis for effective treatment of Alzheimer's disease is one of the critical issues in the field of dementia. This project is an effort to extract... 

    An Improved Clustering Method of Data Mining in Healthcare and Its Implementation

    , M.Sc. Thesis Sharif University of Technology Shourabizadeh, Hamed (Author) ; Akhavan Niaki, Taghi (Supervisor)
    In this study, a brief definition of data mining and its variants were mentioned. Then the methods and algorithms for clustering and their application in the field of healthcare is studied. Concidering the available data for anemia disease, including numeric and categorical attributes, the k-medoids clustering algorithm was selected. This algorithm is one of the simple, powerful and most widely used methods for clustering. The drawbacks of this algorithm are as follow: requires a user input on the number of clusters, depends on the initial data and traps in the local optima. In this thesis, an improved method of clustering-based on Random Forest and k-medoids algorithms has been developed....