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Total 541 records

    Comparison of logarithmic, elliptic, and conical helical spiral for isolation of circulating tumor cells based on inertial method

    , Article Physics of Fluids ; Volume 34, Issue 9 , 2022 ; 10706631 (ISSN) Shamloo, A ; Mozhdehbakhsh Mofrad, Y ; Safari, M ; Naseri, T ; Sharif University of Technology
    American Institute of Physics Inc  2022
    Abstract
    Cancer is one of the most significant causes of death in the world. It has been shown that the role of circulating tumor cells (CTCs) in the early detection of cancer is crucial. Since the number of these cancerous cells in blood is very rare, the inertial microfluidic devices are one of the best candidates for the isolation of CTCs because they result in a high throughput process. Consequently, they can process a large volume of blood in a short time. Despite extensive computational and experimental studies on inertial microfluidic platforms, the impact of the curvature has not been thoroughly investigated during separation. In this paper, the feasibility of isolation of CTCs for... 

    The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis

    , Article Neuroscience and Biobehavioral Reviews ; Volume 140 , 2022 ; 01497634 (ISSN) Narmashiri, A ; Abbaszadeh, M ; Ghazizadeh, A ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase B (MAOB), which causes oxidative stress and destroys dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) and is widely used to create animal models of PD. However, to-date, a comprehensive analysis of the MPTP effects on various aspects of PD does not exist. Here, we provide a systematic review and meta-analysis on the MPTP effects on memory and motor functions by analyzing 51 studies on more than one thousand animals mainly including rats and mice. The results showed that in addition to motor functions... 

    Time-domain ultrasound as prior information for frequency-domain compressive ultrasound for intravascular cell detection: A 2-cell numerical model

    , Article Ultrasonics ; Volume 125 , 2022 ; 0041624X (ISSN) Ghanbarzadeh Dagheyan, A ; Nili, V. A ; Ejtehadi, M ; Savabi, R ; Kavehvash, Z ; Ahmadian, M. T ; Vahdat, B. V ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    This study proposes a new method for the detection of a weak scatterer among strong scatterers using prior-information ultrasound (US) imaging. A perfect application of this approach is in vivo cell detection in the bloodstream, where red blood cells (RBCs) serve as identifiable strong scatterers. In vivo cell detection can help diagnose cancer at its earliest stages, increasing the chances of survival for patients. This work combines time-domain US with frequency-domain compressive US imaging to detect a 20-μ MCF-7 circulating tumor cell (CTC) among a number of RBCs within a simulated venule inside the mouth. The 2D image reconstructed from the time-domain US is employed to simulate the... 

    Apathy exacerbates postural control impairments in stroke survivors: The potential effects of cognitive dual-task for improving postural control

    , Article Neuropsychologia ; Volume 174 , 2022 ; 00283932 (ISSN) Dehmiyani, A ; Mehdizadeh, H ; Azad, A ; Cheraghifard, M ; Jamali, S ; Davoudi, M ; Shokouhyan, S. M ; Taghizadeh, G ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Apathy is a stressor and debilitating common condition for both stroke survivors and their caregivers. However, its effects on the postural control of these patients have not yet been investigated. Improved postural stability through withdrawing attention from postural control by concurrent cognitive task (i.e. dual-task condition) has been reported previously, but the effect of apathy, as a confounding factor, remains unknown. This study aimed to examine the effects of apathy and dual-task condition on postural control of chronic stroke survivors from biomechanical and neurophysiological perspectives. Twenty non-apathetic stroke survivors, 20 apathetic stroke survivors, and 20 sex-, age-,... 

    2D MXene nanocomposites: electrochemical and biomedical applications

    , Article Environmental Science: Nano ; Volume 9, Issue 11 , 2022 , Pages 4038-4068 ; 20518153 (ISSN) Ramezani Farani, M ; Nourmohammadi Khiarak, B ; Tao, R ; Wang, Z ; Ahmadi, S ; Hassanpour, M ; Rabiee, M ; Saeb, M. R ; Lima, E. C ; Rabiee, N ; Sharif University of Technology
    Royal Society of Chemistry  2022
    Abstract
    In recent years, key questions about the interaction of 2D MXene nanomaterials in electrochemical and biomedical applications have been raised. Most research has focused on clarifying the exclusive properties of the materials; however, only limited reports have described the biomedical applications of 2D nanomaterials. 2D MXenes are monolayer atomic nanosheets resulting from MAX phase ceramics. The hydrophilic properties, metallic conductivity, stability, and exclusive physiochemical performances make them promising materials for electrochemical and biomedical applications, including CO2 reduction, H2 evolution, energy conversion and storage, supercapacitors, stimuli-responsive drug delivery... 

    Immunomodulating hydrogels as stealth platform for drug delivery applications

    , Article Pharmaceutics ; Volume 14, Issue 10 , 2022 ; 19994923 (ISSN) Rezaei, Z ; Yilmaz Aykut, D ; Tourk, F. M ; Bassous, N ; Barroso Zuppa, M ; Shawl, A. I ; Ashraf, S. S ; Avci, H ; Hassan, S ; Sharif University of Technology
    MDPI  2022
    Abstract
    Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on... 

    How do the smart travel ban policy and intercity travel pattern affect COVID-19 trends? Lessons learned from Iran

    , Article PLoS ONE ; Volume 17, Issue 10 October , 2022 ; 19326203 (ISSN) Nassiri, H ; Mohammadpour, S. I ; Dahaghin, M ; Sharif University of Technology
    Public Library of Science  2022
    Abstract
    COVID-19, as the most significant epidemic of the century, infected 467 million people and took the lives of more than 6 million individuals as of March 19, 2022. Due to the rapid transmission of the disease and the lack of definitive treatment, countries have employed non-pharmaceutical interventions. This study aimed to investigate the effectiveness of the smart travel ban policy, which has been implemented for non-commercial vehicles in the intercity highways of Iran since November 21, 2020. The other goal was to suggest efficient COVID-19 forecasting tools and to examine the association of intercity travel patterns and COVID-19 trends in Iran. To this end, weekly confirmed cases and... 

    Magnetic nanocomposites for biomedical applications

    , Article Advances in Colloid and Interface Science ; Volume 308 , 2022 ; 00018686 (ISSN) Naghdi, M ; Ghovvati, M ; Rabiee, N ; Ahmadi, S ; Abbariki, N ; Sojdeh, S ; Ojaghi, A ; Bagherzadeh, M ; Akhavan, O ; Sharifi, E ; Rabiee, M ; Saeb, M. R ; Bolouri, K ; Webster, T. J ; Zare, E. N ; Zarrabi, A ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Tissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular, have emerged as promising materials for detecting, directing, and supporting tissue regeneration. There have been many reports concerning the role of these nano-building blocks in the regeneration of both soft and hard tissues, but the subject has not been... 

    A new scheme for the development of IMU-based activity recognition systems for telerehabilitation

    , Article Medical Engineering and Physics ; Volume 108 , 2022 ; 13504533 (ISSN) Nasrabadi, A. M ; Eslaminia, A. R ; Bakhshayesh, P. R ; Ejtehadi, M ; Alibiglou, L ; Behzadipour, S ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Wearable human activity recognition systems (HAR) using inertial measurement units (IMU) play a key role in the development of smart rehabilitation systems. Training of a HAR system with patient data is costly, time-consuming, and difficult for the patients. This study proposes a new scheme for the optimal design of HARs with minimal involvement of the patients. It uses healthy subject data for optimal design for a set of activities used in the rehabilitation of PD1 patients. It maintains its performance for individual PD subjects using a single session data collection and an adaptation procedure. In the optimal design, several classifiers (i.e. NM, k-NN, MLP with RBF as a hidden layer, and... 

    Role of Thigh Muscle Changes in Knee Osteoarthritis Outcomes: Osteoarthritis Initiative Data

    , Article Radiology ; Volume 305, Issue 1 , 2022 , Pages 169-178 ; 00338419 (ISSN) Mohajer, B ; Dolatshahi, M ; Moradi, K ; Najafzadeh, N ; Eng, J ; Zikria, B ; Wan, M ; Cao, X ; Roemer, F. W ; Guermazi, A ; Demehri, S ; Sharif University of Technology
    Radiological Society of North America Inc  2022
    Abstract
    Background: Longitudinal data on the association of quantitative thigh muscle MRI markers with knee osteoarthritis (KOA) outcomes are scarce. These associations are of clinical importance, with potential use for thigh muscle–directed disease-modifying interventions. Purpose: To measure KOA-associated longitudinal changes in MRI-derived muscle cross-sectional area (CSA) and adipose tissue and their association with downstream symptom worsening and knee replacement (KR). Materials and Methods: In a secondary analysis of the Osteoarthritis Initiative multicenter prospective cohort (February 2004 through October 2015), knees of participants with available good-quality thigh MRI scans at baseline... 

    The effects of supervised and non-supervised upper limb virtual reality exercises on upper limb sensory-motor functions in patients with idiopathic Parkinson's disease

    , Article Human Movement Science ; Volume 85 , 2022 ; 01679457 (ISSN) Hashemi, Y ; Taghizadeh, G ; Azad, A ; Behzadipour, S ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Background: Impairments of upper limb (UL) sensory-motor functions are common in Parkinson's disease (PD). Virtual reality exercises may improve sensory-motor functions in a safe environment and can be used in tele-rehabilitation. This study aimed to investigate the effects of supervised and non-supervised UL virtual reality exercises (ULVRE) on UL sensory-motor functions in patients with idiopathic PD. Methods: In this clinical trial study, 45 patients with idiopathic PD (29 male) by mean ± SD age of 58.64 ± 8.69 years were randomly allocated to either the control group (conventional rehabilitation exercises), supervised ULVRE or non-supervised ULVRE. Interventions were 24 sessions, 3... 

    A hierarchical machine learning model based on Glioblastoma patients' clinical, biomedical, and image data to analyze their treatment plans

    , Article Computers in Biology and Medicine ; Volume 150 , 2022 ; 00104825 (ISSN) Ershadi, M. M ; Rahimi Rise, Z ; Akhavan Niaki, S. T ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Aim of study: Glioblastoma Multiforme (GBM) is an aggressive brain cancer in adults that kills most patients in the first year due to ineffective treatment. Different clinical, biomedical, and image data features are needed to analyze GBM, increasing complexities. Besides, they lead to weak performances for machine learning models due to ignoring physicians' knowledge. Therefore, this paper proposes a hierarchical model based on Fuzzy C-mean (FCM) clustering, Wrapper feature selection, and twelve classifiers to analyze treatment plans. Methodology/Approach: The proposed method finds the effectiveness of previous and current treatment plans, hierarchically determining the best decision for... 

    A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery

    , Article Chemical Biology and Drug Design ; Volume 100, Issue 5 , 2022 , Pages 699-721 ; 17470277 (ISSN) Maghsoudi, S ; Taghavi Shahraki, B ; Rameh, F ; Nazarabi, M ; Fatahi, Y ; Akhavan, O ; Rabiee, M ; Mostafavi, E ; Lima, E. C ; Saeb, M. R ; Rabiee, N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches,... 

    CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin

    , Article Chemosphere ; Volume 306 , 2022 ; 00456535 (ISSN) Rabiee, N ; Akhavan, O ; Fatahi, Y ; Ghadiri, A. M ; Kiani, M ; Makvandi, P ; Rabiee, M ; Nicknam, M. H ; Saeb, M. R ; Varma, R. S ; Ashrafizadeh, M ; Nazarzadeh Zare, E ; Sharifi, E ; Lima, E. C ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Overexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression of ssDNA and the related antigens in the population and brisk activity in gene-editing technologies in the treatment/detection may lead to the presence of pCRISPR in the blood. Therefore, the detection and evaluation of their trace concentrations are of... 

    Essential oil nanoemulsion edible coating in food industry: a review

    , Article Food and Bioprocess Technology ; Volume 15, Issue 11 , 2022 , Pages 2375-2395 ; 19355130 (ISSN) Sharma, K ; Babaei, A ; Oberoi, K ; Aayush, K ; Sharma, R ; Sharma, S ; Sharif University of Technology
    Springer  2022
    Abstract
    The food industry is dealing with the challenge of preserving fruits and vegetables and extending their shelf life, so the methods of food preservation have been investigated. Pathogens causing intestinal infections have been identified as a major cause of human disease; therefore, efforts should be made to reduce these pathogens in fruits and vegetables. Essential oils extracted from herbs and edible plants have natural antimicrobial additives. Due to their low water solubility, high volatility, and strong organoleptic qualities, essential oils are not commonly used to reduce microbial growth in fruits and vegetables. To overcome these challenges, encapsulation of essential oils in... 

    Observer-based controller for treatment of hepatitis C infection using fractional order model

    , Article Mathematical Methods in the Applied Sciences ; Volume 45, Issue 17 , 2022 , Pages 10689-10709 ; 01704214 (ISSN) Zeinali, S ; Shahrokhi, M ; Pishro, A ; Sharif University of Technology
    John Wiley and Sons Ltd  2022
    Abstract
    In this study, a stable observer-based feedback controller has been designed for treatment of hepatitis C infectious disease under interferon (IFN) therapy. In order to consider the memory behavior and uncertain nature of this biological system, an unknown dynamics fractional-order (FO) model has been utilized for describing the interactions between the healthy cells, infected cells, and hepatitis C virus (HCV). To cope with unknown dynamics, the fuzzy logic system (FLS) has been utilized. Limitation of the drug efficacy due to its negative side effects has been taken into account as an input saturation. In order to estimate the unknown states which are required for treatment, a full-order... 

    Continuous submicron particle separation Via Vortex-Enhanced ionic concentration polarization: a numerical investigation

    , Article Micromachines ; Volume 13, Issue 12 , 2022 ; 2072666X (ISSN) Dezhkam, R ; Amiri, H.A ; Collins, D.J ; Miansari, M ; Sharif University of Technology
    MDPI  2022
    Abstract
    Separation and isolation of suspended submicron particles is fundamental to a wide range of applications, including desalination, chemical processing, and medical diagnostics. Ion concentration polarization (ICP), an electrokinetic phenomenon in micro-nano interfaces, has gained attention due to its unique ability to manipulate molecules or particles in suspension and solution. Less well understood, though, is the ability of this phenomenon to generate circulatory fluid flow, and how this enables and enhances continuous particle capture. Here, we perform a comprehensive study of a low-voltage ICP, demonstrating a new electrokinetic method for extracting submicron particles via flow-enhanced... 

    The effects of smoking on female sexual dysfunction: a systematic review and meta-analysis

    , Article Archives of Women's Mental Health ; Volume 25, Issue 6 , 2022 , Pages 1021-1027 ; 14341816 (ISSN) Salari, N ; Hasheminezhad, R ; Abdolmaleki, A ; Kiaei, A ; Shohaimi, S ; Akbari, H ; Nankali, A ; Mohammadi, M ; Sharif University of Technology
    Springer  2022
    Abstract
    The increased number of female smokers is considered a global health challenge in recent years. One of the detrimental effects of smoking is sexual hormone fluctuation causing female sexual dysfunction (FSD). This systematic review and meta-analysis aimed to investigate the effects of smoking leading to FSD. Electronic databases (PubMed, Scopus, Web of Science, Embase, Science Direct, and Google Scholar) were hired for systematic searching. Until June 2022, whole qualified studies reporting the consequences of smoking on FSD were gathered for data analysis based on the random effects model (CMA software, v.2). Study heterogeneity and publication bias were also assessed using I2 index and... 

    Clinical validation of a smartphone-based handheld ECG device: A validation study

    , Article Critical Pathways in Cardiology ; Volume 21, Issue 4 , 2022 , Pages 165-171 ; 1535282X (ISSN) Ahmadi-Renani, S ; Gharebaghi, M ; Kamalian, E ; Hajghassem, H ; Ghanbari, A ; Karimi, A ; Mansoury, B ; Dayari, M. S ; Khatmi Nemati, M ; Karimi, A ; Zarghami, M. H ; Vasheghani Farahani, A ; Sharif University of Technology
    Lippincott Williams and Wilkins  2022
    Abstract
    Background: Remote cardiac monitoring and screening have already become an integral telemedicine component. The wide usage of several different wireless electrocardiography (ECG) devices warrants a validation study on their accuracy and reliability. Methods: Totally, 300 inpatients with the Nabz Hooshmand-1 handheld ECG device and the GE MAC 1200 ECG system (as the reference) were studied to check the accuracy of the devices in 1 and 6-limb lead performance. Simultaneous 10-second resting ECGs were assessed for the most common ECG parameters in lead I. Afterward, 6-lead ECGs (limb leads), were performed immediately and studied for their morphologies. Results: Of the 300 patients, 297 had... 

    A discrete differential evolution with local search particle swarm optimization to direct angle and aperture optimization in IMRT treatment planning problem

    , Article Applied Soft Computing ; Volume 131 , 2022 ; 15684946 (ISSN) Fallahi, A ; Mahnam, M ; Akhavan Niaki, S. T ; Sharif University of Technology
    Elsevier Ltd  2022
    Abstract
    Intensity-modulated radiation therapy is a well-known technique for treating cancer patients worldwide. A treatment plan in this technique requires decision-making for three main problems: selection of beam angles, intensity map calculation, and leaf sequencing. Previous works investigated these problems sequentially. We present a new integrated framework for simultaneous decision-making of directions, intensities, and aperture shape, called direct angle and aperture optimization, and develop a mixed-integer nonlinear mathematical model for the problem. Due to the nonlinearity and the dimension of the problem, three efficient metaheuristics based on differential evolution (DE) called classic...