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Hybrid nanomaterials containing PAMAM, polyrotaxane and quantum dot blocks

Adeli, M ; Sharif University of Technology | 2011

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  1. Type of Document: Article
  2. DOI: 10.1142/S1793292011002561
  3. Publisher: 2011
  4. Abstract:
  5. Pseudopolyrotaxanes, Ps-PR, consisting of α-cyclodextrin rings, polyethylene glycol axes and end triazine groups were prepared and then were capped by amino-functionalized quantum dots, NH 2-QDs, to achieve polyrotaxanes. The amino-functionalized QDs stoppers of polyrotaxanes were used as core to synthesize polyamidoamine, PAMAM, dendrons divergently and hybrid nanomaterials were obtained. Synthesized hybrid nanomaterials were characterized by different spectroscopy, microscopy and thermal analysis methods. They were freely soluble in water and their aqueous solutions were stable at room temperature over several months. Due to their biocompatible backbone, high functionality and water solubility synthesized hybrid nanomaterials are promising carriers and probes in cancer diagnosis and therapy
  6. Keywords:
  7. Drug delivery systems ; Quantum dot ; Cancer diagnosis ; Cyclodextrin rings ; Dendrons ; Drug delivery system ; Hybrid nanomaterials ; PAMAM ; Polyamidoamines ; Polyrotaxanes ; Pseudopolyrotaxanes ; Room temperature ; Water solubilities ; Dendrimers ; Drug delivery ; Glycols ; Hydrogels ; Nanostructured materials ; Polyethylene glycols ; Thermoanalysis ; Semiconductor quantum dots
  8. Source: Nano ; Volume 6, Issue 3 , June , 2011 , Pages 239-249 ; 17932920 (ISSN)
  9. URL: http://www.worldscientific.com/doi/abs/10.1142/S1793292011002561