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Optimization of Tribenuron-methyl determination by differential pulse polarography using experimental design

Ahmadi, S ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1039/b9ay00068b
  3. Abstract:
  4. Differential pulse polarography (DPP) was applied for the determination of the herbicide Tribenuron-methyl (TBM). This is a first study for various parameters affecting the reduction peak current were simultaneously optimized using experimental design and these results are different from other reports. The effect of factors such as voltage step, voltage step time, pulse amplitude, pulse time, sample pH, concentration of the supporting electrolyte and the mercury drop size were assessed by means of a (27-2) fractional factorial design. It was found that the effects and interactions of four out of seven factors were significant. Consequently, a central composite design (CCD) with four factors, i.e., voltage step time, pulse amplitude, pulse time and sample pH was performed and an optimum response surface equation was derived. The statistical parameters of the derived model were R2 = 0.95 and F = 20.38. The limit of detection (LOD), limit of quantification (LOQ), linear range and relative standard deviation (RSD) were 36 μg L-1, 119 μg L-1, 0.07-20 mg L-1 and 0.03, respectively. The promising results for the determination of TBM in a trace level show the efficiency of factorial design and response surface methodologies in optimizing the parameters of a DPP method
  5. Keywords:
  6. Central composite designs ; Concentration of ; Differential pulse polarography ; Effect of factors ; Experimental design ; Factorial design ; Fractional factorial designs ; Limit of detection ; Limit of quantifications ; Linear range ; Mercury drop ; Pulse amplitude ; Pulse time ; Reduction peak currents ; Relative standard deviations ; Response surface ; Response Surface Methodology ; Sample pH ; Statistical parameters ; Supporting electrolyte ; Trace level ; Voltage step ; Design ; Earth boring machines ; Herbicides ; Mercury (metal) ; Optimization ; Polarographic analysis ; Pulse amplitude modulation ; Statistics ; Surface properties ; Trace analysis ; Tunneling machines ; pH effects
  7. Source: Analytical Methods ; Volume 2, Issue 1 , 2010 , Pages 41-48 ; 17599660 (ISSN)
  8. URL: http://pubs.rsc.org/en/Content/ArticleLanding/2010/AY/b9ay00068b#!divAbstract