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Curcumin-loaded amine-functionalized mesoporous silica nanoparticles inhibit α-synuclein fibrillation and reduce its cytotoxicity-associated effects

Taebnia, N ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.1021/acs.langmuir.6b02935
  3. Publisher: American Chemical Society , 2016
  4. Abstract:
  5. This study aimed to develop a drug carrier based on amine-functionalized mesoporous silica nanoparticles (AAS-MSNPs) for a poorly water-soluble drug, curcumin (CUR), and to study its effects on α-synuclein (α-Syn) fibrillation and cytotoxicity. Here, we show that AAS-MSNPs possess high values of loading efficiency and capacity (33.5% and 0.45 mg drug/mg MSNPs, respectively) for CUR. It is also revealed that α-Syn species interact strongly with the CUR-loaded AAS-MSNPs, leading to a significant inhibition of the fibrillation process. Furthermore, these samples reduce the toxic effects of CUR. However, drug-loaded AAS-MSNPs do not affect the cytotoxic properties of the formed fibrils considerably. In addition, CUR loaded onto AAS-MSNPs shows enhanced stability in comparison with that of the free drug. These remarkable properties introduce AAS-MSNPs as a promising tool for the formulation of poorly water-soluble drugs such as CUR
  6. Keywords:
  7. Cytotoxicity ; Mesoporous materials ; Nanoparticles ; Silica ; Amine-functionalized mesoporous silica ; Cytotoxic ; Drug carrier ; Enhanced stability ; Loading efficiency ; Poorly water-soluble drugs ; Synuclein ; Toxic effect ; Atomic absorption spectrometry
  8. Source: Langmuir ; Volume 32, Issue 50 , 2016 , Pages 13394-13402 ; 07437463 (ISSN)
  9. URL: http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b02935