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Highly efficient one-pot three-component mannich reaction under solvent-free conditions

Azizi, N ; Sharif University of Technology | 2009

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  1. Type of Document: Article
  2. Publisher: 2009
  3. Abstract:
  4. A mild and practically-convenient one-pot procedure for the direct Mannich reaction has been developed using a condensation of amines, aldehydes and unmodified ketones under solvent free conditions in the presence of Znl 2 with good to excellent yields. The present methodology offers several advantages, such as excellent yields, simple procedures, short reaction times and milder conditions with very small amounts of catalyst. Furthermore, it is the first time that the catalytic activity of several catalysts under solvent free conditions has been studied. It was found that both the diastereoselectivity and the rate of reaction were improved with various Lewis acids and metal oxides. However, the chiral catalysts, such as L-cystine, (-)-cinchonidine and L-proline, did not work well in terms of yield and diastereo selectivity under this condition. © Sharif University of Technology, December 2009
  5. Keywords:
  6. Aldehyde ; Amine ; Catalyst ; Maanich reaction ; Solvent-free ; Amine catalysts ; Catalytic activity ; Chiral catalyst ; Diastereo-selectivity ; L-cystine ; L-proline ; Lewis Acid ; Mannich reactions ; Metal oxides ; One pot ; One-pot procedures ; Rate of reaction ; Reaction solvents ; Short reaction time ; Solvent free conditions ; Three-component ; Aldehydes ; Catalysis ; Catalyst selectivity ; Ketones ; Solvents ; Catalyst activity ; Amino acid ; Ammonium compound ; Carbonyl compound ; Catalysis ; Condensation ; Efficiency measurement ; Reaction rate ; Solvent
  7. Source: Scientia Iranica ; Volume 16, Issue 2 C , 2009 , Pages 94-98 ; 10263098 (ISSN)
  8. URL: https://www.sid.ir/en/journal/ViewPaper.aspx?id=164837