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Conductive nanofiber scaffold for bone tissue engineering

Rasti Boroojeni, F ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1109/ICBME.2017.8430283
  3. Publisher: Institute of Electrical and Electronics Engineers Inc , 2018
  4. Abstract:
  5. In order to fabricate nanofiber scaffold for bone tissue engineering, electrospinning technique was employed. This technique produces nanofiberous scaffold supporting cell adhesion, migration, and proliferation. Here, we developed a novel conductive scaffold from poly-caprolactone, gelatin, and poly aniline/graphene nanoparticles. In this study, co-electrospinning was utilized to fabricate composite electrospun scaffold. The effect of polyaniline/graphene (PAG) nanoparticles on the mechanical properties and electrical conductivity of this hybrid scaffold was investigated. The result showed that PAG nanoparticles enbance both mechanical properties and electrical conductivity of the scaffolds. The biocompatibility of the scaffold evaluated by culturing rat bone marrow-derived mesenchymal stem cells (BMSCs) on the scaffolds indicated that the fabricated hybrid nanofiber scaffold supported BMSCs adhesion and proliferation. © 2017 IEEE
  6. Keywords:
  7. Bone tissue engineering ; Gelatin ; Polyaniline/graphene nanoparticles ; Aniline ; Biocompatibility ; Biomechanics ; Biophysics ; Bone ; Cell adhesion ; Cell culture ; Electric conductivity ; Electrospinning ; Mechanical properties ; Nanofibers ; Nanoparticles ; Polyaniline ; Polycaprolactone ; Stem cells ; Tissue ; Co-electrospinning ; Conductive nanofibers ; Electrical conductivity ; Electrospinning techniques ; Electrospun scaffolds ; Nanofiber scaffold ; Scaffolds (biology)
  8. Source: 24th Iranian Conference on Biomedical Engineering and 2017 2nd International Iranian Conference on Biomedical Engineering, ICBME 2017, 30 November 2017 through 1 December 2017 ; 2018 ; 9781538636091 (ISBN)
  9. URL: https://ieeexplore.ieee.org/abstract/document/8430283